Mayumi Hamasaki

Functional landscape of mechanistic diversity in 27 claudin family members at tight junctions

Hiroka Kashihara, Hiroo Tanaka, Manabu Kitamata, Gen Shiratsuchi et autres

The diversity of epithelial paracellular barriers, essential for various biological functions, is primarily determined by the combination of 27 claudins (Cldns) that form tight junctions (TJs). However, the basis of their functional diversity remains largely unexplored. Here, we generated complete Cldn -null …

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Functional landscape of mechanistic diversity in 27 claudin family members at tight junctions

Hiroka Kashihara, Hiroo Tanaka, Manabu Kitamata, Gen Shiratsuchi et autres

The diversity of epithelial paracellular barriers, essential for various biological functions, is primarily determined by the combination of 27 claudins (Cldns) that form tight junctions (TJs). However, the basis of their functional diversity remains largely unexplored. Here, we generated complete Cldn-null mouse …

Development of an Early Post-discharge Childcare Anxiety Scale and Evaluation of Its Reliability and Validity

Ayako Takamori, Miyuki Nagamatsu, Mayumi Hamasaki, Atsushi Kawaguchi

目的：退院後早期の育児不安という状態にある母親を把握するために，育児不安尺度を開発し信頼性と妥当性を検証する．

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Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides

Fumito Wada, Tsuyoshi Yamamoto, Tadayuki Kobayashi, Keisuke Tachibana et autres

Antisense oligonucleotides (ASOs) containing bridged nucleic acids (BNAs) have been proven to be very powerful. However, ensuring a reliable discovery and translational development scheme for this class of ASOs with wider therapeutic windows remains a fundamental challenge. We here demonstrate the robustness …

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Development of a Self-Management Scale of PMS during Childrearing Periods and Examination of its Validity and Reliability

Mayumi Hamasaki, Yoko Tokiwa

Objective: The objective of this study was to develop a “Self-Management Scale of Premenstrual Syndrome (PMS) during Childrearing Periods” for mothers currently raising children and to examine the validity and reliability of the scale. Methods: Participants included mothers aged 20 to 44 …

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Pregnenolone Functions in Centriole Cohesion during Mitosis

Mayumi Hamasaki, Shigeru Matsumura, Ayaka Satou, Chisato Takahashi et autres

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ABL1 regulates spindle orientation in adherent cells and mammalian skin

Shigeru Matsumura, Mayumi Hamasaki, Takuya Yamamoto, Miki Ebisuya et autres

Despite the growing evidence for the regulated spindle orientation in mammals, a systematic approach for identifying the responsible genes in mammalian cells has not been established. Here we perform a kinase-targeting RNAi screen in HeLa cells and identify ABL1 as a novel …

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The relationships between Sense of Coherence, breastfeeding self-efficacy and burden of breastfeeding among mothers with early confinement periods

Makiko Yamasaki, Sigemi Iriyama, Mayumi Hamasaki, Youko Honda

Receptor Tyrosine Kinase Ror2 Mediates Wnt5a-induced Polarized Cell Migration by Activating c-Jun N-terminal Kinase via Actin-binding Protein Filamin A

Akira Nomachi, Michiru Nishita, Daisuke Inaba, Masahiro Enomoto et autres

The receptor tyrosine kinase Ror2 has recently been shown to act as an alternative receptor or coreceptor for Wnt5a and to mediate Wnt5a-induced migration of cultured cells. However, little is known about the molecular mechanism underlying this migratory process. Here we show …

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