Jianghua Zheng

Targeted delivery of si-CircERI3 via cartilage-affinity lipid nanoparticle-microspheres improves senescent osteoarthritic cartilage

Fang Chen, Mingchen Zhang, Chu Zhang, Jianghua Zheng et autres

High hydrostatic pressure–induced structural remodeling of walnut meal protein and its functional implications: Integrated experimental and molecular dynamics insights

Weiqian Wang, Guoli Yan, J Li, Yang Tian et autres

Walnut meal protein (WMP) represents an underutilized plant protein resource with considerable application potential. However, the molecular basis underlying its structural responsiveness to high hydrostatic pressure (HHP) remains insufficiently elucidated. This study systematically investigated the effects of HHP (100–600 MPa, 5–20 min) …

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Exploring possible benefits of Amomum tsaoko Crevost et Lemaire on growth, meat quality and gut flora in white-feather broilers

Yan Min Shen, Jiangrui Yang, Xingjiao Jiang, Gang Ping Tan et autres

This study investigated the effects of Amomum tsao-ko (ATK) extract, administered as a feed additive, on the meat quality of white-feathered broilers. We used 36 birds randomly assigned to three groups: a control group, a low-dose ATK group, and a high-dose ATK …

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A Metastasis-competent CAF Subpopulation Defined by MFAP5⁺THY1⁺ Co-expression Drives Prostate Cancer Metastasis via EMT Activation

Yongqiang Huang, Yu Wang, Wei Zhang, Wenfeng Wang et autres

BACKGROUND: The tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), contributes to prostate cancer (PCa) metastasis, however, the role of CAF heterogeneity remains incompletely characterized. The study aims to identify and functionally characterize a metastasis-competent CAF subpopulation in PCa and evaluate its potential as …

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Supplementary Figures S1-S13 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer

Chen Huang, Wenbo Zhou, Aiwu Bian, Qiansen Zhang et autres

Fig. S1. Structure-based ligand discovery of STAT3 inhibitorsFig. S2. Surface plasmon resonance analysis of interactions between WB436B to STATfamily proteinsFig. S3. The biology evaluation of WB436B inactive analogue WB345Fig. S4. The mutation in STAT3 SH2 domain directly inhibited STAT3 transcriptionalactivitiesFig. S5. WB436B …

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Supplementary Methods from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer

Chen Huang, Wenbo Zhou, Aiwu Bian, Qiansen Zhang et autres

Supplementary Methods

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Supplementary Tables S1-S6 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer

Chen Huang, Wenbo Zhou, Aiwu Bian, Qiansen Zhang et autres

Table S1. List of antibodies used and their technical information Table S2. The sequence of Real-time PCR primersTable S3. The sequence of shRNAs for silencing STAT3 Table S4. The sequence of ChromatinImmunoprecipitation (Ch-IP) PCRTable S5. The binding affinities of WB436B towards STAT …

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Coral dealbatus Crude Polysaccharide Attenuates Fat Accumulation and Intestinal Flora Disorders in Mice Fed with a High-Fat Diet

Yan Min Shen, Jianyang Fu, Jinya Dong, Jun He et autres

Obesity, a major risk factor for cardiometabolic diseases, arises from chronic energy imbalance and ectopic lipid deposition. This study investigated the anti-obesity potential of Coral dealbatus crude polysaccharides (CDP), a previously uncharacterized bioactive fraction from a hybrid vegetable cultivar developed by the …

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Assessing the suitability of boiling in the boletus species: a multimodal analysis of texture, flavor, and volatile profiles

Feng Zhang, Cunchao Zhao, Xiaolin Huang, Yuwei Guo et autres

Multi-dimensional characterization was conducted to assess post-boiling quality variations among five Boletus species, with the aim of identifying the most suitable variety for boiling. Texture profile analysis revealed that Suillus luteus (HLT) and Leccinum aurantiacum (HC) exhibited tender textures, Boletus edulis (MW) …

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Fermented walnut milk alleviates high-fat-diet-induced obesity in mice via modulating gut microbiota and lipid metabolism

Jianghua Zheng, Muhammad Aaqil, Chongying Shi, Cunchao Zhao et autres

Plant-based products represent promising alternatives to animal-derived foods, offering solutions to health and environmental challenges. This study evaluates the lipid-lowering effects of fermented walnut milk and elucidates its underlying mechanisms using a high-fat diet (HFD)-induced obesity mouse model. Results demonstrated that fermented …

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Process optimization and flavor characteristics of cream cheese fermented with avocado co-cultures

Feng Zhang, Yaling Gu, Yuwei Guo, Muhammad Aaqil et autres

This study investigated the impact of avocado co-fermentation on the texture, microstructure, and flavor profile of cream cheese. Avocado puree served as an substrate for R704, yielding a viable cell count of 187.67 × 10 6 CFU/g after fermentation. All five starter …

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Unveiling the potential of Rumex hanus diets on chicken meat quality: Insights from metabolomics and molecular dynamics approach

Yuwei Guo, Yaling Gu, Muhammad Aaqil, Feng Zhang et autres

In order to solve the problem of loose meat quality and single flavor level of broiler chicken, the present study was conducted to improve the quality characteristics of chicken by incorporating unfermented (URH) and fermented Rumex hanus (FRH) in basal diets. URH …

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