Hernán Quiceno

CLDN18.2 expression in gastroesophageal adenocarcinoma: prevalence, heterogeneity, and prognostic implications in Spanish patients

Carolina Martínez‐Ciarpaglini, Sandra Pérez‐Buira, Aitana Bolea, C BELLIDO et autres

Claudin 18 isoform 2 (CLDN18.2) has emerged as a novel therapeutical target for HER2-negative, locally advanced, or metastatic gastroesophageal adenocarcinoma. However, reported prevalence rates vary widely (24-47%), underscoring the need for accurate population-specific data. This study investigates the CLDN18.2 prevalence in Spanish …

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Development of SOCS1 mimetics as novel approach to harmonize inflammation, oxidative stress, and fibrogenesis in metabolic dysfunction-associated steatotic liver disease

Susana Bernal, Ignacio Priéto, Maria E. Kavanagh, Isabel Herrero del Real et autres

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver disease, encompassing a spectrum from simple steatosis to steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma. As part of metabolic syndrome, MASLD/MASH is characterized by inflammation, oxidative stress, and fibrosis, highlighting the …

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Semaglutide Improves Liver Steatosis and De Novo Lipogenesis Markers in Obese and Type-2-Diabetic Mice with Metabolic-Dysfunction-Associated Steatotic Liver Disease

Manuel Soto‐Catalán, Lucas Opazo-Ríos, Hernán Quiceno, Iolanda Lázaro et autres

Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a prevalent clinical condition associated with elevated morbidity and mortality rates. Patients with MASLD treated with semaglutide, a glucagon-like peptide-1 receptor agonist, demonstrate improvement in terms of liver damage. However, the mechanisms underlaying this beneficial effect …

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Rate of non-invasive follicular thyroid neoplasms with papillary-like nuclear features depends on pathologist’s criteria: a multicentre retrospective Southern European study with prolonged follow-up

Miguel Paja, Carles Zafón, Carmela Iglesias, Aitziber Ugalde et autres

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Anti-NXP2–Positive Paraneoplastic Dermatomyositis With Histopathologic Changes Confined to the Acrosyringia

José Luis Ramírez-Bellver, Elena Atienza Macías, Claudia Bernárdez, Joaquín López‐Robles et autres

BACKGROUND: Paraneoplastic syndromes consist of a group of disorders that are not related to the extension of the primary tumor or its metastases and that might be the first manifestation of a hidden neoplasm. It is a well-known association between dermatomyositis (DM) …

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Index lesion characterization by 11C‐Choline PET/CT and Apparent Diffusion Coefficient parameters at 3 Tesla MRI in primary prostate carcinoma

Miguel Hernández‐Argüello, Hernán Quiceno, Ignacio Pascual, José Luis Solórzano et autres

BACKGROUND: Index lesion characterization is important in the evaluation of primary prostate carcinoma (PPC). The aim of this study was to analyze the contribution of (11) C-Choline PET/CT and the Apparent Diffusion Coefficient maps (ADC) in detecting the Index Lesion and clinically …

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Miositis proliferativa con metaplasia ósea. Reporte de un caso

Luis D. Mejías, José Luis Solórzano, Jorge A. Árabe, Hernán Quiceno et autres

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Agreement between preoperative transvaginal ultrasound and intraoperative macroscopic examination for assessing myometrial infiltration in low‐risk endometrioid carcinoma

L. Pineda, Juan Luis Alcázar, María Jesús Morales Caparrós, José Ángel Mínguez et autres

OBJECTIVE: To compare diagnostic performance of preoperative transvaginal ultrasound (TVS) and intraoperative macroscopic examination for determining myometrial infiltration in women with low-risk endometrial cancer, and to estimate the agreement between the two methods. METHODS: This was a single-center observational study comprising women …

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