Susana Bernal

Development of SOCS1 mimetics as novel approach to harmonize inflammation, oxidative stress, and fibrogenesis in metabolic dysfunction-associated steatotic liver disease

Susana Bernal, Ignacio Priéto, Maria E. Kavanagh, Isabel Herrero del Real et autres

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver disease, encompassing a spectrum from simple steatosis to steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma. As part of metabolic syndrome, MASLD/MASH is characterized by inflammation, oxidative stress, and fibrosis, highlighting the …

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The presence of activating IgG Fc receptors in macrophages aggravates the development of experimental abdominal aortic aneurysm

Laura Lopez‐Sanz, Susana Bernal, Luna Jiménez-Castilla, Marisa Pardines et autres

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La presencia de receptores Fc de IgG activadores en macrófagos agrava el desarrollo de aneurisma aórtico abdominal experimental

Laura Lopez‐Sanz, Susana Bernal, Luna Jiménez-Castilla, Marisa Pardines et autres

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P.0456 Early administration of aripiprazole long-acting formulations reduces length of hospital stay of psychiatric inpatients

Susana Bernal, M. Forcada, Liesl Gonzales, Santiago Ovejero

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Cellular senescence mechanisms in age- and diabetes-associated vascular and renal damage.

Luna Jiménez-Castilla, César Mateo, Susana Bernal, Laura Lopez‐Sanz et autres

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PS5, A peptidomimetic of suppressor of cytokine signaling 1, as a novel antioxidant and anti-inflammatory agent to prevent atherosclerosis

Sara La Manna, Laura Lopez‐Sanz, Susana Bernal, Luna Jiménez-Castilla et autres

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Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development

Laura Lopez‐Sanz, Susana Bernal, Luna Jiménez-Castilla, Ignacio Priéto et autres

BACKGROUND: Abdominal aortic aneurysm (AAA), a degenerative vascular pathology characterized by permanent dilation of the aorta, is considered a chronic inflammatory disease involving innate/adaptive immunity. However, the functional role of antibody-dependent immune response against antigens present in the damaged vessel remains unresolved. …

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Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics

Sara La Manna, Laura Lopez‐Sanz, Susana Bernal, Sara Fortuna et autres

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Protective effect of suppressor of cytokine signalling 1‐based therapy in experimental abdominal aortic aneurysm

Susana Bernal, Laura Lopez‐Sanz, Luna Jiménez-Castilla, Ignacio Priéto et autres

BACKGROUND AND PURPOSE: Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by chronic inflammation, oxidative stress and proteolytic activity in the aortic wall. Targeting JAK/signal transducer and activator of transcription (JAK/STAT) pathway is a promising strategy for chronic inflammatory diseases. We …

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Antioxidant Effects of PS5, a Peptidomimetic of Suppressor of Cytokine Signaling 1, in Experimental Atherosclerosis

Sara La Manna, Laura Lopez‐Sanz, Susana Bernal, Luna Jiménez-Castilla et autres

The chronic activation of the Janus kinase/signal transducer and activator of the transcription (JAK/STAT) pathway is linked to oxidative stress, inflammation and cell proliferation. Suppressors of cytokine signaling (SOCS) proteins negatively regulate the JAK/STAT, and SOCS1 possesses a small kinase inhibitory region …

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Targeting NF-κB by the Cell-Permeable NEMO-Binding Domain Peptide Improves Albuminuria and Renal Lesions in an Experimental Model of Type 2 Diabetic Nephropathy

Lucas Opazo-Ríos, Anita Plaza, Yenniffer Sánchez Matus, Susana Bernal et autres

Diabetic nephropathy (DN) is a multifactorial disease characterized by hyperglycemia and close interaction of hemodynamic, metabolic and inflammatory factors. Nuclear factor-κB (NF-κB) is a principal matchmaker linking hyperglycemia and inflammation. The present work investigates the cell-permeable peptide containing the inhibitor of kappa …

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P3113Functional deficiency in activating fcgamma receptor protects against aortic abdominal aneurysm in mice

Laura Lopez‐Sanz, Susana Bernal, Luna Jiménez-Castilla, Ana Melgar et autres

Abstract Background and aim Abdominal aortic aneurysm (AAA) is a degenerative disorder characterized by a localized and permanent dilation of the aorta. Pathological features of AAA include proteolysis, vascular smooth muscle cells (VSMC) apoptosis, oxidative stress and inflammation. Previous studies have demonstrated …

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