James E. Mills

Integrating Fragment Screening and Covalent Chemistry to Drug DNA-Binding Proteins: RAD52 as a Case Study

Nicolas Bocquet, A. Potenza, Jason Clochard, Anika Kuster et autres

ch, cn, gb, il (code pays fourni par la source)

Integrating Fragment Screening and Covalent Chemistry to Drug DNA-Binding Proteins: RAD52 as a Case Study

Nicolas Bocquet, A. Potenza, Jason Clochard, Anika Kuster et autres

ch, cn, gb, il (code pays fourni par la source)

C92, a proton channel-blocking allosteric STING agonist generates robust antitumor activity

Monali Banerjee, Sandip Kumar Middya, Ritesh Shrivastava, Anindita Middya et autres

gb, fr (code pays fourni par la source)

Identification of Selective Small Molecule Modulators of mRNA Processing Using a Multiplexed QuantiGene High-Throughput Screening Platform

Sarah Sirin, Nirodhini S Siriwardana, Michael Wood, James E. Mills et autres

us, gb (code pays fourni par la source)

MAIP: An Open-Source Tool to Enrich High-Throughput Screening Output and Identify Novel, Druglike Molecules with Antimalarial Activity

Nicolas Bosc, Eloy Félix, Mark Gardner, James E. Mills et autres

gb, in, ch, Kenya (code pays fourni par la source)

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out

Koen J. Dechering, Martijn Timmerman, Kim Rensen, Karin M. J. Koolen et autres

nl, ch, gb, Kenya (code pays fourni par la source)

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum , using a nano luciferase reporter read-out

Koen J. Dechering, Martijn Timmerman, Kim Rensen, Karin M. J. Koolen et autres

nl, ch, gb, Kenya (code pays fourni par la source)

The Pandemic Response Box─Accelerating Drug Discovery Efforts after Disease Outbreaks

Kirandeep Samby, Dominique Besson, Anirban Dutta, Buddhadev Patra et autres

ch, in (code pays fourni par la source)

CCDC 2027033: Experimental Crystal Structure Determination

Jean‐Olivier Zirimwabagabo, Ameera B. A. Jailani, Paris Avgoustou, Matthew J. Tozer et autres

Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure–Activity Relationships and Optimization

Jean‐Olivier Zirimwabagabo, Ameera B. A. Jailani, Paris Avgoustou, Matthew J. Tozer et autres

gb (code pays fourni par la source)

Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin-2 Receptor

Paris Avgoustou, Ameera B. A. Jailani, Jean‐Olivier Zirimwabagabo, Matthew J. Tozer et autres

gb, us, jp (code pays fourni par la source)

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

Andrew Fedoriw, Satyajit Rajapurkar, Shane W. O’Brien, Sarah V. Gerhart et autres

us (code pays fourni par la source)