Guilherme Augusto dos Santos

FORMAÇÃO DOCENTE E INTERDISCIPLINARIDADE NA ERA DIGITAL: PERSPECTIVAS PARA O DESENVOLVIMENTO PROFISSIONAL DOS PROFESSORES

Francisco Jorge Gondim, Maria Edilania dos Santos Nunes, Guilherme Augusto dos Santos, Elciete de Campos Moraes Brum et autres

As mudanças provocadas pelas tecnologias digitais têm transformado também a forma de ensinar e aprender, exigindo dos professores novas competências e uma formação que vá além do domínio de conteúdos específicos. Nesse meio, a interdisciplinaridade surge como uma possibilidade de integrar diferentes …

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Moderate‐intensity aerobic exercise attenuates obesity‐induced changes in perivascular adipose tissue in female mice

Teresa M. Da‐Re, Guilherme Augusto dos Santos, C. Risso, Sílvio Roberto Consonni et autres

The goal of the study was to investigate the effects of aerobic exercise training on inflammatory, oxidative stress, and cellular senescence biomarkers, along with the evaluation of morphology and anti-contractile response of perivascular adipose tissue of the thoracic aorta (tPVAT) in female …

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Metastatic breast cancer, what to do? Is it treatable? – Case Report

Tamiris Mogne, Guilherme Augusto dos Santos, Nathália Paiva de Andrade, B Cordeiro et autres

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Use of audiovisual resources in the teaching of the photomotor reflex

Giovana de Sousa Ferro Barbosa, Guilherme Augusto dos Santos, Carlos Eduardo Vieira, Helena Vieira Goudard et autres

The photomotor reflex, or pupillary light reflex, is characterized by the contraction of the pupils in response to a light stimulus that penetrates the eye. This mechanism involves connections between the retina and brainstem neurons, mediated by cranial nerves. Assessment of this …

FASN inhibition sensitizes metastatic OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1

Luciana Yamamoto Almeida, FERNANDA DOS SANTOS MOREIRA, Guilherme Augusto dos Santos, Florence Juana María Cuadra Zelaya et autres

OBJECTIVES: To investigate the potential effect of fatty acid synthase (FASN) inhibitor orlistat to enhance the effectiveness of chemotherapy drugs widely used to treat oral squamous cell carcinomas (OSCC), such as 5-fluorouracil, cisplatin, and paclitaxel. METHODS: The OSCC SCC-9 LN-1 metastatic cell …

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The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia

Carolina Hassibe Thomé, Germano Aguiar Ferreira, Diego A. Pereira‐Martins, Guilherme Augusto dos Santos et autres

Non-T cell activation linker (NTAL) membrane protein depletion from lipid rafts by alkylphospholipids or downregulation by shRNA knockdown decreases cell viability through regulation of the Akt/PI3K pathway in mantle cell lymphoma and acute promyelocytic leukemia cells. Here, we confirmed that the knockdown …

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NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia

Carolina Hassibe Thomé, Germano Aguiar Ferreira, Diego A. Pereira‐Martins, Guilherme Augusto dos Santos et autres

Non-T cell activation linker (NTAL) is a lipid raft-membrane protein expressed by normal and leukemic cells and involved in cell signaling. In acute promyelocytic leukemia (APL), NTAL depletion from lipid rafts decreases cell viability through regulation of the Akt/PI3K pathway. The role …

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The lipid raft protein NTAL participates in AKT signaling in mantle cell lymphoma

Germano Aguiar Ferreira, Carolina Hassibe Thomé, Ana Maria Simão, Priscila Santos Scheucher et autres

= 5), indicating that NTAL participates in tumor growth. NTAL protein was detected by western blotting in circulating cells of 7 of 8 MCL patients in the leukemic phase, suggesting involvement in the progression of the disease.

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Combination of the Fatty Acid Synthase Inhibitor Orlistat with Cisplatin or Paclitaxel: Effects on Metastatic Tongue Squamous Cell Carcinoma Cells

Luciana Yamamoto Almeida, Fernanda Santos Moreira, Guilherme Augusto dos Santos, Estêvão Azevedo Melo et autres

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LAT2, a Lipid Raft Protein That Participates in AKT Phosphorylation in Mantle Cell Lymphoma, Is a Target for Perifosine Chemotherapy

Germano Aguiar Ferreira, Carolina Hassibe Thomé, Priscila Santos Scheucher, Andréia Machado Leopoldino et autres

Abstract Introduction: Lipid rafts are highly ordered membrane domains that are enriched in cholesterol and sphingolipids and provide an environment for signal transduction proteins which control cell survival and cell death. Altered raft assembly has been implicated in cancer progression. Alkylphospholipids (APL) …

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Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia

Guilherme Augusto dos Santos, Lev M. Kats, Pier Paolo Pandolfi

Acute promyelocytic leukemia (APL) is a hematological malignancy driven by a chimeric oncoprotein containing the C terminus of the retinoic acid receptor-a (RARa) fused to an N-terminal partner, most commonly promyelocytic leukemia protein (PML). Mechanistically, PML-RARa acts as a transcriptional repressor of …

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The Transcripts Of Platelet-Endothelial Adhesion Molecules and Inflamatory Chemokine Activation Pathway Molecules Are Hyperexpressed In The Bone Marrow Of Acute Promyelocytic Leukemia Patients Presenting Severe Coagulopathy

Priscila Santos Scheucher, Guilherme Augusto dos Santos, Rodrigo Alexandre Panepucci, Amélia G. Araújo et autres

Abstract Although Acute Promyelocytic Leukemia (APL) is now considered one of the most curable forms of acute leukemia, it is an aggressive disease associated with a high frequency of bleeding and thrombosis. Indeed, the leading cause of treatment failure in APL is …

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