Miriam Koopman

A real-world analysis of metastasectomy in patients with small intestinal adenocarcinoma presenting with metastasized disease

Pascale J.M. Schafrat, Demy Danielsson, Felice N. van Erning, Rutger‐Jan Swijnenburg et autres

BACKGROUND: Small intestinal adenocarcinoma (SIA) is a rare gastrointestinal malignancy, often diagnosed at an advanced stage, resulting in poor overall survival (OS). Limited disease specific treatment guidelines are available, especially regarding patients with metastatic disease. This study aims to describe observed differences …

nl (code pays fourni par la source)

AI-based augmentation of oncology clinical trials

Andrea Villa, Ashley L. Eadie, David Synnott, Rebecca Romanò et autres

it, us, ie, fr, sg, nl, es (code pays fourni par la source)

Leave No Data Behind: Exploring a new paradigm in oncology with foundation models and large language models

Federica Corso, Aleksandra Zec, Margherita Favali, Marta Ligero et autres

Foundation models (FMs) and large language models (LLMs) are transforming cancer AI by integrating heterogeneous data sources, including medical imaging, electronic health records, and molecular profiles. By learning from large-scale, unstructured, and label-free inputs, these models may support diagnosis, biomarker discovery, prognostic …

it, de, es, gb, us, fr, nl (code pays fourni par la source)

Phase I Dose-Escalation Study Combining Irinotecan-Loaded Drug-Eluting Bead Chemoembolization with Yttrium-90 Glass Microsphere Radioembolization in Colorectal Liver Metastases (DEBIR90Y)

Li Shen Ho, Ahmed A. Alsultan, Maarten L. J. Smits, Miriam Koopman et autres

PURPOSE: Y) glass microspheres, with drug-eluting beads preloaded with irinotecan (DEBIRI) in patients with colorectal liver metastases (CRLMs). MATERIALS AND METHODS: Y glass microsphere radioembolization at increasing dose levels (60-Gy, 80-Gy, and 100-Gy perfused normal liver absorbed doses), followed by DEBIRI, using …

nl, us (code pays fourni par la source)

Mapping the anatomical landscape of colorectal tumours: Location-specific efficacy of anti-epidermal growth factor receptor antibodies: Pooled analysis of randomised trials

Kenta Iguchi, Kentaro Yamazaki, Toshihiro Misumi, Hideaki Bando et autres

jp, fr, nl, be, de, us, it (code pays fourni par la source)

Image-based consensus molecular subtypes and colon cancer recurrence: Understanding the impact of lifestyle factors across subtypes of colon cancer

Evertine Wesselink, Dieuwertje E. Kok, Maxime W. Lafarge, Anne‐Sophie van Lanen et autres

Aim We investigated associations between consensus molecular subtype (CMS) and colon cancer recurrence, and explored how the inflammatory potential of diet and lifestyle relate to recurrence across CMS subgroups. Methods A nested case-control study was implemented in two prospective cohorts of colon …

nl, ch, gb (code pays fourni par la source)

Abstract CT157: MEDOCC-CrEATE trial update: Feasibility of measuring circulating tumor DNA post-surgery to guide adjuvant chemotherapy in stage II colon cancer patients

Ingrid A. Franken, Suzanna J. Schraa, Steven L. C. Ketelaars, Carmen Rubio Alarcon et autres

Abstract Introduction: Patients with stage II colon cancer (CC) not classified as high risk do not receive adjuvant chemotherapy (ACT) according to Dutch guidelines. However, 15-20% of patients with stage II CC experience disease recurrence, highlighting an unmet clinical need to identify …

nl, us (code pays fourni par la source)

Safety and efficacy of lapatinib, binimetinib, and vinorelbine for RAS mutant metastatic colorectal cancer: results of the RASTRIC Phase I/II trial

Maarten A. Huismans, Eelke Hiddo Gort, Lisa T. van der Heijden, Sermin M. Guven Mese et autres

nl (code pays fourni par la source)

Abstract 5325: Cell-free DNA fragmentomes for treatment response monitoring in patients with metastatic colorectal cancer: The Dolphin study.

Denise van Steijn, Lorenzo Rinaldi, Adrià Closa, Erica Peters et autres

Abstract Introduction: Accurate monitoring of tumor response in patients with metastatic colorectal cancer (mCRC) undergoing systemic therapy is essential to enable timely and informed treatment decisions. Although CT imaging is currently the standard-modality, it has limitations including limited accuracy for detecting small …

nl, us (code pays fourni par la source)

Mapping treatment response in metastatic colorectal cancer using organoids and genomic profiling

Lidwien Smabers, Onderzoek Medische Oncologie, Cancer, Miriam Koopman et autres

This thesis focuses on improving personalized treatment strategies for patients with metastatic colorectal cancer. Although new targeted therapies have become available, many patients still do not respond to their treatment. To better match therapies to each individual, this research combines broad genomic …

A comparison by mismatch repair status of real-world characteristics and outcomes in patients with stage II/III rectal cancer in the Netherlands

R.A. Lunenberg, Ingrid A. Franken, Frederieke H. van der Baan, Femke P.C. Sijtsma et autres

A subset of rectal cancer (RC), <5%, exhibits mismatch repair deficiency (dMMR); the remaining are classified as proficient (pMMR). Reported evidence on differences between dMMR and pMMR RC is limited. In this nationwide Dutch study, we compared patients with dMMR and pMMR …

Assessing Overall Survival Benefits in Advanced Cancers: The Role of External Comparator Cohort Studies with Real‐World Data

Francesco Pignatti, Tarec Christoffer El‐Galaly, Martin Kaiser, Kimmo Porkka et autres

External comparator cohort (ECC) studies with real-world data (RWD) may provide more reliable estimates of treatment differences compared to single-arm trials (SAT), yet they face limitations such as selection bias and data heterogeneity. This study assessed the perceived strength of evidence of …

nl, dk, gb, fi, us, ch, se, it, es, il (code pays fourni par la source)