Zhuoli Zhang

Sustained remission in refractory Schnitzler syndrome presenting with prominent acropachy: from anakinra induction to firsekibart maintenance

Xiaoying Sun, Shuang Gao, Juan Zhao, Ke Wang et autres

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The glutamine-glutamate metabolic axis in autoimmune rheumatic diseases: immunometabolic regulation and therapeutic potential

Yujing Li, Hong Yu, Zhuoli Zhang

Autoimmune rheumatic diseases (AIRDs), such as rheumatoid arthritis and systemic lupus erythematosus, represent a heterogeneous group of chronic inflammatory disorders characterized by loss of self-tolerance and persistent immune activation. Growing evidence indicates that metabolic reprogramming is essential for immune cell activation and …

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Longitudinal comparison of treat-to-target states and clinical outcomes in patients with late-onset versus early-onset systemic lupus erythematosus

Worawit Louthrenoo, Alberta Hoi, Vera Golder, Yi‐Hsing Chen et autres

OBJECTIVE: We compared demographic and clinical characteristics between patients with late-onset (LO) and early-onset (EO) systemic lupus erythematosus (SLE) and examined their longitudinal associations with treatment targets and long-term outcomes, irreversible organ damage accrual and health-related quality of life (HRQoL). METHODS: We …

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Predictors of intramuscular glucocorticoid bridge therapy failure in rheumatoid arthritis: a real-world observational study

Wenhui Xie, Dai Gao, Hong Huang, Zhuoli Zhang

Background: Intramuscular glucocorticoid (GCs) bridge therapy is an equivalently recommended bridging strategy to oral GCs for rheumatoid arthritis (RA) under predefined tapering and discontinuation schemes. Objectives: We aimed to investigate the risk factors of intramuscular GCs bridge therapy failure in RA. Design: …

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IRE1/p‑JNK/NRF2 axis-mediated GPX4 upregulation underlies ferroptosis resistance in rheumatoid arthritis fibroblast-like synoviocytes

Jiaxi Liu, Wenhui Xie, Y J Cao, L Zhang et autres

BACKGROUND: Rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLS) exhibit chronic endoplasmic reticulum stress with activation of the IRE1/phospho‑JNK arm of the unfolded protein response; yet, they remain resistant to apoptosis. Although ferroptosis has been implicated in the pathogenesis of rheumatoid arthritis, the mechanisms underlying …

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The Disappearing Jawbone

Xiaoying Sun, Lanlan Ji, Ke Wang, Zhuoli Zhang

A 48-year-old man presented to our department with a 20-year history of acne conglobate and mandibular pain. He initially developed left mandibular pain, followed by atrophy of the mandible. The patient's left mandibular pain resolved within months of a single 30 mg …

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Are RAS inhibitors necessary during intensive immunosuppression for lupus nephritis? Real-world evidence from the STAR cohort

Xiaohui Zhang, Xiuli Zhang, Juan Zhao, Yong Fan et autres

OBJECTIVE: While guidelines advocate renin-angiotensin system inhibitors (RASi) for renoprotection in lupus nephritis (LN), evidence is largely extrapolated from non-lupus populations. Evidence specifically evaluating RASi efficacy during the intensive induction phase of active LN remains scarce. This study aimed to evaluate the …

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Evaluation of Candidate Definitions of Severe Refractory Systemic Lupus Erythematosus Using Clinical Outcomes: Real-World Data Exploration Study

Rangi Kandane‐Rathnayake, Vera Golder, Worawit Louthrenoo, Yi‐Hsing Chen et autres

Radiomics Combined with CT-FFR for Detecting Myocardial Ischemia: Prospective Cohort Study (Preprint)

Yan Yi, Cheng Xu, Xianbo Yu, Wei Wu et autres

BACKGROUND Current coronary CT angiography (CCTA)-based methods have limited accuracy in identifying myocardial ischemia. Radiomics may help to provide a more accurate assessment. OBJECTIVE To investigate the diagnostic and reclassification value of myocardial radiomic signatures combined with CCTA-derived fractional flow reserve (CT-FFR) …

Predictors of damage accrual by organ domain in systemic lupus erythematosus

Rangi Kandane‐Rathnayake, Luigi Zolio, Jiyoon C. Choi, Vera Golder et autres

OBJECTIVES: Organ damage in SLE is assessed using the SLICC/ACR Damage Index (SDI), which quantifies damage in 12 organ systems but generally reports a total score. We examined whether the risk factors for overall organ damage accrual captured those associated with domain-specific …

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NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), and SII (systemic immune-inflammation index) reflect disease activity and renal remission in patients with lupus nephritis

Xiaohui Zhang, Yuan Chen, Yong Fan, Dai Gao et autres

Objective To evaluate the value of NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), and SII (systemic immune-inflammation index) in reflecting disease activity and induction therapy remission in patients with lupus nephritis (LN). Methods Active LN patients from STAR cohort …

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Prevalence, Determinants, and Outcomes of Low Disease Activity and Remission Attainment in Patients With Systemic Lupus Erythematosus That Is Clinically Active

Yanjie Hao, Dylan Hansen, Rangi Kandane‐Rathnayake, Worawit Louthrenoo et autres

OBJECTIVE: This study aimed to identify in patients with systemic lupus erythematosus (SLE) with clinically active disease the attainment of frequency and determinants of Lupus Low Disease Activity State (LLDAS) and Definition of Remission in SLE (DORIS) and the frequency and determinants …

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