Mary Kate Bonner

FDA Approval Summary: Datopotamab Deruxtecan-dlnk for Treatment of Patients with Unresectable or Metastatic, HR-Positive, HER2-Negative Breast Cancer

Melanie Royce, Mirat Shah, Joyce Cheng, Mary Kate Bonner et autres

On January 17, 2025, the FDA approved datopotamab deruxtecan-dlnk (DATROWAY; Dato-DXd), a Trop-2-directed antibody and topoisomerase inhibitor conjugate, for the treatment of adults with unresectable or metastatic, hormone receptor-positive, HER2-negative breast cancer who have received prior endocrine-based therapy and chemotherapy for unresectable …

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Cohesin-mediated stabilization of the CCAN complex at kinetochores in mitosis

Julian Haase, Koly Aktar, Mary Kate Bonner, Léonard Colin et autres

The constitutive centromere-associated network (CCAN) of the inner kinetochore links CENP-A-containing nucleosomes of the centromere to the outer kinetochore, ensuring accurate chromosome segregation during mitosis. CCAN binding at the centromere is stabilized upon mitotic entry, but the underlying mechanisms remain unclear. Here, …

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The TFIIH complex is required to establish and maintain mitotic chromosome structure

Julian Haase, Richard Chen, Wesley M Parker, Mary Kate Bonner et autres

Condensins compact chromosomes to promote their equal segregation during mitosis, but the mechanism of condensin engagement with and action on chromatin is incompletely understood. Here, we show that the general transcription factor TFIIH complex is continuously required to establish and maintain a …

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Author response: The TFIIH complex is required to establish and maintain mitotic chromosome structure

Julian Haase, Richard Chen, Wesley M Parker, Mary Kate Bonner et autres

The general transcription factor TFIIH complex promotes the establishment and maintenance of chromosome structure during mitosis by altering the chromatin environment to allow for proper loading and function of the condensin complexes on chromatin.

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The TFIIH Complex is Required to Establish and Maintain Mitotic Chromosome Structure

Julian Haase, Richard Chen, Mary Kate Bonner, Lisa M. Jenkins et autres

Abstract Condensins compact chromosomes to promote their equal segregation during mitosis, but the mechanism of condensin engagement with and action on chromatin is incompletely understood. Here, we show that the general transcription factor TFIIH complex is continuously required to establish and maintain …

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The Borealin dimerization domain interacts with Sgo1 to drive Aurora B–mediated spindle assembly

Mary Kate Bonner, Julian Haase, Hayden Saunders, Hindol Gupta et autres

egg extracts and biochemical reconstitution, we found that Sgo1 interacts directly with the dimerization domain of the CPC subunit Borealin. Borealin and the PP2A phosphatase complex can bind simultaneously to the coiled-coil domain of Sgo1, suggesting that Sgo1 can integrate Aurora B …

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Enrichment of Aurora B kinase at the inner kinetochore controls outer kinetochore assembly

Mary Kate Bonner, Julian Haase, Jason Swinderman, Hyunmi Halas et autres

Outer kinetochore assembly enables chromosome attachment to microtubules and spindle assembly checkpoint (SAC) signaling in mitosis. Aurora B kinase controls kinetochore assembly by phosphorylating the Mis12 complex (Mis12C) subunit Dsn1. Current models propose Dsn1 phosphorylation relieves autoinhibition, allowing Mis12C binding to inner …

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Distinct Roles of the Chromosomal Passenger Complex in the Detection of and Response to Errors in Kinetochore-Microtubule Attachment

Julian Haase, Mary Kate Bonner, Hyunmi Halas, Alexander E. Kelly

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Correction: Profiling of the Mammalian Mitotic Spindle Proteome Reveals an ER Protein, OSTD-1, as Being Necessary for Cell Division and ER Morphology

Mary Kate Bonner, Bo Hwa Han, Ahna R. Skop

[This corrects the article DOI: 10.1371/journal.pone.0077051.].

Profiling of the Mammalian Mitotic Spindle Proteome Reveals an ER Protein, OSTD-1, as Being Necessary for Cell Division and ER Morphology

Mary Kate Bonner, Bo Hwa Han, Ahna R. Skop

Cell division is important for many cellular processes including cell growth, reproduction, wound healing and stem cell renewal. Failures in cell division can often lead to tumors and birth defects. To identify factors necessary for this process, we implemented a comparative profiling …

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Mitotic Spindle Proteomics in Chinese Hamster Ovary Cells

Mary Kate Bonner, Daniel S. Poole, Tao Xu, Ali Sarkeshik et autres

Mitosis is a fundamental process in the development of all organisms. The mitotic spindle guides the cell through mitosis as it mediates the segregation of chromosomes, the orientation of the cleavage furrow, and the progression of cell division. Birth defects and tissue-specific …

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Cell division screens and dynamin

Mary Kate Bonner, Ahna R. Skop

Cell division is the most fundamental process in the development of all living organisms. The generation of cell diversity throughout development, the multiplication of cells during wound repair and the maintenance of stem cells in several tissues and organs all rely on …

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