Mohd Nasir Mat Nor

Retinal Vulnerability to Light Pollution in Vitiligo: A Narrative Review of the Role of Melanin Loss in Ocular Phototoxicity

Maria Ana Contin, Manuel G. Bruera, Mohd Nasir Mat Nor, Mónica L. Acosta

Background: Vitiligo is a condition characterized by the loss of pigmentation in certain areas of the body. It occurs when pigment-producing cells, called melanocytes, die or stop producing melanin, the pigment responsible for skin color. This loss of pigmentation can affect any …

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Retinal Hyperreflective Foci Are Biomarkers of Ocular Disease: A Scoping Review With Evidence From Humans and Insights From Animal Models

Mohd Nasir Mat Nor, Colin Richard Green, David Squirrell, Mónica L. Acosta

Background: Abnormalities in the retina have a profound impact on vision, and accurate diagnosis and monitoring are essential for effective clinical management. Retinal hyperreflective foci (HRF), lesions, or dots, identified using optical coherence tomography (OCT), are observed in both animals and humans …

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Bridging the gap: Exploring the intercurrent relationship between knee osteoarthritis and cerebral small vessel disease.

Mazira Mohamad Ghazali, Nor Farid Mohd Noor, Muhamad Afiq Mahayidin, Mohd Nasir Mat Nor et autres

Knee osteoarthritis (KOA) and cerebral small vessel disease (CSVD) are two prevalent and debilitating conditions that have traditionally been studied within distinct medical disciplines - rheumatology and neurology, respectively. However, emerging evidence suggests a deeper connection between these seemingly disparate diseases, transcending …

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Hyper‐reflective dots in optical coherence tomography imaging and inflammation markers in diabetic retinopathy

Mohd Nasir Mat Nor, Cindy X. Guo, Colin Richard Green, David Squirrell et autres

The aim of this study is to correlate small dot hyper-reflective foci (HRF) observed in spectral domain optical coherence tomography (SD-OCT) scans of an animal model of hyperglycaemia with focal electroretinography (fERG) response and immunolabelling of retinal markers. The eyes of an …

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Flavonol Quercetin: Immunomodulatory And Anticancer Properties

Aung Myo Oo, Mohd Nasir Mat Nor, Ohn Mar Lwin, Nordin Simbak

Background: Cancer is one of the critical, challenging problems in a clinical setting among non-infectious diseases and poses a considerable burden to the community for its highest fatalities and associated morbidities. Immunotherapy has paid much attention to curbing cancer and protecting against …

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Immunomodulatory effects of apigenin, luteolin, and quercetin through natural killer cell cytokine secretion

Aung Myo Oo, Mohd Nasir Mat Nor, Ohn Mar Lwin, Nordin Simbak et autres

Nutritional immunology has attracted the interest of researchers due to its positive impact on health and immunity.By secreting cytotoxic granules and producing cytokines, natural killer (NK) cells are pivotal in fighting against viruses and cancer.Polyphenolic secondary metabolites, like flavonoids, have potent immunomodulatory …

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Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases

Mohd Nasir Mat Nor, Ilva D. Rupenthal, Colin Richard Green, Mónica L. Acosta

Dysregulation of retinal function in the early stages of light-induced retinal degeneration involves pannexins and connexins. These two types of proteins may contribute to channels that release ATP, leading to activation of the inflammasome pathway, spread of inflammation and retinal dysfunction. However, …

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Connexin therapeutics: blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions

Mónica L. Acosta, Mohd Nasir Mat Nor, CindyX Guo, Odunayo Omolola Mugisho et autres

Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases. Some of these compounds are now in clinical trials, but for many of them, the literature is inconclusive about …

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Role of Brain-Derived Neurotrophic Factor in Cognitive Function and Exercise

Mya Mya Thwin, Ma Saung Oo, Mohd Nasir Mat Nor, San Thitsa Aung et autres

Brain-Derived Neurotrophic Factor (BDNF) is a member of neurotrophins and it plays important role in both peripheral nervous system (PNS) and short-term, as well as long-term plasticity in central nervous system. Physical exercise fosters neurocognitive functions and brain plasticity at all ages. …

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The relationship between serum brain - derived neurotrophic factor (bdnf) level and cognitive function in middle aged male chronic smokers

Myitzu Han, Mya Mya Thwin, Myat San Yi, Khin Than Yee et autres

Cigarette smoking is a pervasive high-risk behavior and recent studies reported that nicotine in tobacco influences a wide variety of cognitive domains. BDNF is one of the factors of the neurotrophin family that can regulate the cognitive functions of the brain. The …

Connexin Hemichannel Block Using Orally Delivered Tonabersat Improves Outcomes in Animal Models of Retinal Disease

Mohd Nasir Mat Nor, Ilva D. Rupenthal, Colin Richard Green, Mónica L. Acosta

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Connexin hemichannel block shuts down inflammation in an animal model of chronic diabetic retinopathy to improve structural and functional outcomes

Colin Richard Green, Mohd Nasir Mat Nor, Odunayo Omolola Mugisho, Ilva D. Rupenthal et autres

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