Odunayo O. Mugisho

A Cationic Block Co‐Polymer for Gene Delivery in the Posterior Segment of the Eye

Amber Monteiro, Odunayo O. Mugisho, Antonio de Souza, Lina Liu et autres

Diseases of the back of the eye such as neovascular age-related macular degeneration (nAMD) are vision threatening and treatment is burdensome for patients, often requiring ocular injections every other month. Injection risks and logistics lower patient compliance; however, even patients receiving optimal …

ca, nz (code pays fourni par la source)

Inhibiting the NLRP3 inflammasome pathway: An effective way to treat chronic inflammation in experimental autoimmune uveitis

Avik Shome, Odunayo O. Mugisho, Priyanka Agarwal, Rachael L. Niederer et autres

This study aimed to determine whether topical and/or oral administration of a nucleotide-binding oligomerization domain- (NOD-) like receptor (NLR) protein 3 (NLRP3) inflammasome blocker can reduce signs of chronic inflammation in experimental autoimmune uveitis (EAU) mice. Mice were treated daily with the …

nz (code pays fourni par la source)

Linking HbA1c and white blood cell counts to the development of diabetic macular edema in type 2 diabetes: A systematic review and meta-analysis

Nguyen Quoc Khanh Le, Charisse Y. J. Kuo, Stuti L. Misra, Rinki Murphy et autres

nz (code pays fourni par la source)

Gas-based therapies in chronic wounds: A scoping review of preclinical and clinical data

Srikar Kasha, Sara M Hannin, Odunayo O. Mugisho, Sachin Thakur

INTRODUCTION: Chronic wounds are injuries that persist beyond expected healing timeframes. Although they have varying aetiologies abnormal development, prolonged inflammation and evident hypoxia are common features in all chronic wounds. Innovative treatments are sought and gas-based therapies in particular have shown promise …

nz (code pays fourni par la source)

Small Extracellular Vesicles Released from ARPE-19 Cells Grown under Diabetic Retinopathy Conditions Promote NLRP3 Inflammasome Activation

Henry H. Louie, Odunayo O. Mugisho, Lawrence W. Chamley, Ilva D. Rupenthal

The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is a multiprotein complex that forms part of the innate immune system. Recent studies have shown that the inflammasome pathway is upregulated in diabetic retinopathy (DR), resulting in breakdown of the retinal pigment …

nz, Nigéria, pt (code pays fourni par la source)

Characterisation of vitreous derived small extracellular vesicles in diabetic retinopathy

Henry H. Louie, Ilva D. Rupenthal, Julie C. Lim, Lawrence W. Chamley et autres

Diabetic retinopathy (DR) is a progressive retinal disease driven by microvascular dysfunction and inflammation, ultimately leading to vision loss. Early detection is essential for preventing irreversible damage; however, the asymptomatic nature of early-stage DR limits the effectiveness of current screening methods. Emerging …

nz (code pays fourni par la source)

Tonabersat Inhibits Retinal Inflammation After Hypoxia–Ischemia in the Neonatal Rat

Jack Jonathan Maran, Alice McDouall, Justin M. Dean, Joanne O. Davidson et autres

Perinatal hypoxic-ischemic encephalopathy (HIE) is a condition resulting from oxygen deprivation around the time of birth and may be associated with death, brain damage, and disability. Alongside this, studies have shown that HIE may result in visual impairment. Previously, this was thought …

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The NLRP3 inflammasome pathway contributes to chronic inflammation in experimental autoimmune uveitis

Avik Shome, Ilva D. Rupenthal, Rachael L. Niederer, Odunayo O. Mugisho

BACKGROUND: Noninfectious uveitis, a chronic ocular inflammatory disease, is characterized by the activation of immune cells in the eye, with most studies focusing on the role of the adaptive immune system in the disease. However, limited data exist on the potential contribution …

nz (code pays fourni par la source)

Serum Albumin and Glycemic Variability Could Contribute to Diabetic Retinopathy Progression by Regulating Chronic Inflammatory Pathways

Jack Jonathan Maran, Charisse Y. J. Kuo, Ilva D. Rupenthal, Rinki Murphy et autres

Purpose Despite managing glycemic levels and other risk factors, individuals with type 2 diabetes (T2DM) may still experience diabetic retinopathy (DR) progression. This study investigated clinical predictors of DR progression in T2DM patients following bariatric surgery. Methods This study was a retrospective …

nz (code pays fourni par la source)

Future Therapeutics: Targeting the NLRP3 Inflammasome Pathway to Manage Diabetic Retinopathy Development and Progression

Charisse Y. J. Kuo, Ilva D. Rupenthal, Rinki Murphy, Odunayo O. Mugisho

While existing local therapies partially restore vision loss from diabetic retinopathy (DR), there is currently no reliable treatment to prevent the onset or stop the progression of the disease. This review seeks to explore the inflammatory molecular mechanisms underpinning DR pathogenesis, which …

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Correlative light and X-ray tomography jointly unveil the critical role of connexin43 channels on inflammation-induced cellular ultrastructural alterations

Chidinma Okolo, Jack Jonathan Maran, Amy Watts, Jaime Maripillán et autres

Non-junctional connexin43 (Cx43) plasma membrane hemichannels have been implicated in several inflammatory diseases, particularly playing a role in ATP release that triggers activation of the inflammasome. Therapies targeting the blocking of the hemichannels to prevent the pathological release or uptake of ions …

gb, nz, cl (code pays fourni par la source)

NLRP3 inflammasome plays a vital role in the pathogenesis of age-related diseases in the eye and brain

Jack Jonathan Maran, Odunayo O. Mugisho

NLRP3 inflammasome plays a vital role in the pathogenesis of agerelated diseases in the eye and brain Key points: With aging, there is increased nucleotide-binding oligomerization domain-(NOD-) like receptor (NLR) protein-3 (NLRP3) activation in neural and ocular tissues.Activation of the NLRP3 inflammasome …

nz (code pays fourni par la source)