Edries Yousaf Hajam

Vaccination-based immunotherapy to target profibrotic cells in liver and lung

Michal Sobecki, Jing Chen, Ewelina Krzywińska, Shunmugam Nagarajan et autres

Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis

Sunny Kataria, Isha Rana, Krithika Badarinath, Rania Faouzi Zaarour et autres

Fibrosis results from excessive extracellular matrix (ECM) deposition, which causes tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, and ECM production. However, it remains unclear if the same fibroblast performs all of the processes that …

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Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis

Isha Rana, Sunny Kataria, Tuan Lin Tan, Edries Yousaf Hajam et autres

Systemic sclerosis is a fibrotic disease that initiates in the skin and progresses to internal organs, leading to a poor prognosis. Unraveling the etiology of a chronic, multifactorial disease such as systemic sclerosis has been aided by various animal models that recapitulate …

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Vaccination-based immunotherapy to target profibrotic cells in liver and lung

Michal Sobecki, Jing Chen, Ewelina Krzywińska, Shunmugam Nagarajan et autres

Fibrosis is the final path of nearly every form of chronic disease, regardless of the pathogenesis. Upon chronic injury, activated, fibrogenic fibroblasts deposit excess extracellular matrix, and severe tissue fibrosis can occur in virtually any organ. However, antifibrotic therapies that target fibrogenic …

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The expanding impact of T-regs in the skin

Edries Yousaf Hajam, Patricia Panikulam, Chung-Ching Chu, Haarshaadri Jayaprakash et autres

As the interface between the body and the environment, the skin functions as the physical barrier against external pathogens and toxic agents. In addition, the skin is an immunologically active organ with a plethora of resident adaptive and innate immune cells, as …

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Mindin is essential for cutaneous fibrogenesis in a new mouse model of systemic sclerosis

Isha Rana, Sunny Kataria, Tuan Lin Tan, Edries Yousaf Hajam et autres

ABSTRACT Fibrosis is a result of chronically activated fibroblasts leading to the overproduction of extracellular matrix (ECM), causing tissue hardening and loss of organ function. Systemic sclerosis (SSc) is a fibrotic skin disease marked by inflammation, autoimmunity and vasculopathy along with progressive …

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Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival

Rania Faouzi Zaarour, Bilal Azakir, Edries Yousaf Hajam, Husam Nawafleh et autres

Programmed cell death or type I apoptosis has been extensively studied and its contribution to the pathogenesis of disease is well established. However, autophagy functions together with apoptosis to determine the overall fate of the cell. The cross talk between this active …

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Innovative and Frugal Protocols for RNA Related Experiments

Jameel Ahmad Khan, B. Fakrudin, Edries Yousaf Hajam, H. E. Shashidhar

Rice is staple crop and is being cultivated far and wide around the globe. Waterlogged habit of cultivation has made rice extremely sensitive to drought. Understanding expression profiles will open new avenues of research for drought tolerance in rice. Present study aims …

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PAI1 mediates fibroblast–mast cell interactions in skin fibrosis

Neha Pincha, Edries Yousaf Hajam, Krithika Badarinath, Surya Prakash Rao Batta et autres

Fibrosis is a prevalent pathological condition arising from the chronic activation of fibroblasts. This activation results from the extensive intercellular crosstalk mediated by both soluble factors and direct cell-cell connections. Prominent among these are the interactions of fibroblasts with immune cells, in …

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The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis

Manando Nakasaki, Yongsung Hwang, Yun Xie, Sunny Kataria et autres

Fibrosis is a pervasive disease in which the excessive deposition of extracellular matrix (ECM) compromises tissue function. Although the underlying mechanisms are mostly unknown, matrix stiffness is increasingly appreciated as a contributor to fibrosis rather than merely a manifestation of the disease. …

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