Lian Liu

A 26-Gram Butterfly-Inspired Robot Achieving Autonomous Tailless Flight

Weibin Gu, Chenrui Feng, Lian Liu, Chen Yang et autres

cn, it, uz (code pays fourni par la source)

[Electroacupuncture improves synaptic plasticity and cognitive dysfunction via down-regulating HDAC3 in mice of Alzheimer's disease].

Lanfeng Lai, Xin Li, Hongzhu Li, Zhimin Li et autres

OBJECTIVES: To observe the effect of electroacupuncture(EA) on histone deacetylase 3 (HDAC3), synaptic plasticity and N-methyl-D-aspartate (NMDA) receptors in the hippocampus of mice with Alzheimer's disease(AD), so as to explore the underlying mechanism of EA in treatment of AD. METHODS: 5XFAD mice …

cn (code pays fourni par la source)

Template-independent genome editing in the Pcdh15 mouse, a model of human DFNB23 nonsyndromic deafness

Lian Liu, Linzhi Zou, Kuan Li, Hanqing Hou et autres

Although frameshift mutations lead to 22% of inherited Mendelian disorders in humans, there is no efficient in vivo gene therapy strategy available to date, particularly in nondividing cells. Here, we show that nonhomologous end-joining (NHEJ)-mediated nonrandom editing profiles compensate the frameshift mutation …

cn (code pays fourni par la source)

An L1 retrotransposon insertion–induced deafness mouse model for studying the development and function of the cochlear stria vascularis

Chenmeng Song, Jie Li, Shuang Liu, Hanqing Hou et autres

Significance To gain better hearing sensitivity, the energetic and metabolic supplies are crucial for cochlea to develop a blood-labyrinth barrier containing abundant capillaries and cellular compartments. For example, the stria vascularis, the power plant of the cochlea, generates a +80 mV endocochlear …

cn (code pays fourni par la source)

PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice

Jie Li, Shuang Liu, Chenmeng Song, Qun Hu et autres

Significance Some animals have evolved an adaptive ability for vocalizing and hearing ultrasonic frequencies that are inaudible to humans (>20 kHz). For decades, it has been postulated that animals hear ultrasonic frequencies with cochlear hair cells using an identical set of mechanotransduction …

cn (code pays fourni par la source)

Template-independent genome editing and repairing correct frameshift disease in vivo

Lian Liu, Kuan Li, Linzhi Zou, Hanqing Hou et autres

Abstract Frameshift mutation caused by small insertions/deletions (indels) often generate truncated and non-functional proteins, which underlies 22% inherited Mendelian disorders in humans. However, there is no efficient in vivo gene therapy strategies available to date, especially in postmitotic systems. Here, we leveraged …

cn (code pays fourni par la source)

PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice

Jie Li, Shuang Liu, Chenmeng Song, Qun Hu et autres

Abstract Ultrasonic hearing is exploited for hunting and navigation as in echolocation by microbats and bottleneck dolphins, and for social communication like ultrasonic vocalization by mice and rats. However, the molecular and cellular basis for ultrasonic hearing is not known yet. Here …

cn (code pays fourni par la source)

TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice

Shuang Liu, Shufeng Wang, Linzhi Zou, Jie Li et autres

Hearing sensation relies on the mechano-electrical transducer (MET) channel of cochlear hair cells, in which transmembrane channel-like 1 (TMC1) and transmembrane channel-like 2 (TMC2) have been proposed to be the pore-forming subunits in mammals. TMCs were also found to regulate biological processes …

cn, hk (code pays fourni par la source)

Author response: TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice

Shuang Liu, Shufeng Wang, Linzhi Zou, Jie Li et autres

Other than its function in mechanotransduction, TMC1 is indispensable for action potential firing of auditory hair cells by mediating a leak conductance that alters tonotopically along the cochlea coil.

us, cn, hk (code pays fourni par la source)

TMC1 Confers a Leak Conductance to Modulate Excitability of Auditory Hair Cells in Mammals

Shuang Liu, Shufeng Wang, Linzhi Zou, Jie Li et autres

ABSTRACT Hearing sensation relies on the mechano-electrical transducer (MET) channel of cochlear hair cells, in which Transmembrane channel-like 1 (TMC1) and TMC2 have been proposed to be the pore-forming subunits. Meanwhile it has been reported that TMCs regulate other biological processes in …

cn (code pays fourni par la source)

Surgery-free video-oculography in mouse models: enabling quantitative and short-interval longitudinal assessment of vestibular function

Xiaojie Yang, Shiyue Zhou, Jiaojiao Wu, Qun Liao et autres

cn, sg, hk, us (code pays fourni par la source)

Study on Rheological Behaviors of Slurry for Tape Casting of ZrO_2 Ceramic

Lian Liu

The rheological properties of slurry for tape-casting of nano-ZrO2 powder have been researched.The Slurry was prepared by using the an hydrous ethanol and acetone(volume ratio of 1 ∶ 1) as mixed solvent,polyvinyl butyal(PVB) as a binder,and triglyceride(TG) as a dispersant,and and Dioctyl …

cn (code pays fourni par la source)