[Electroacupuncture improves synaptic plasticity and cognitive dysfunction via down-regulating HDAC3 in mice of Alzheimer's disease].
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OBJECTIVES: To observe the effect of electroacupuncture(EA) on histone deacetylase 3 (HDAC3), synaptic plasticity and N-methyl-D-aspartate (NMDA) receptors in the hippocampus of mice with Alzheimer's disease(AD), so as to explore the underlying mechanism of EA in treatment of AD. METHODS: 5XFAD mice were randomly divided into EA group, model group and sham-acupuncture group, with 13 mice in both the EA group and the model group, and 7 mice in the sham-acupuncture group. Thirteen wild-type mice from the same litter were taken as the normal control group. The mice in the EA group received EA at "Baihui" (GV20)and "Dazhui" (GV14) for 15 min once daily, 6 times a week for 4 weeks. The mice in the sham-acupuncture group received sham EA, i.e., the needle was inserted into the rubber clay which was placed on the surface of the corresponding acupoints. The novel object recognition(NOR), Y-maze and Morris water maze(MWM) tests were used to observe the cognitive functions of mice. Electrophysiological technique was used to detect long-term potentiation (LTP) of the hippocampal neurons and Western blot was used to detect the relative expressions of HDAC3 and NMDAR-related receptors (NMDAR1, NMDAR2A, NMDAR2B) in the hippocampus. RESULTS: <0.05). CONCLUSIONS: EA of GV20 and GV14 can restore the impaired LTP and improve the cognitive impairment, which may be related to increasing the expressions of NMDA-related receptor proteins and down-regulating the expression of HDAC3 in the hippocampus of 5XFAD mice.
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Guangzhou University of Chinese Medicine South China Research Center for Acupuncture and Moxibustion pays non établi dans la noticeUniversité ou école supérieure
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Guangzhou Eighth People's Hospital pays non établi dans la noticeÉtablissement de santé
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Foshan Hospital of TCM pays non établi dans la noticeÉtablissement de santé
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Clinical School of Acupuncture and Rehabilitation pays non établi dans la noticeUniversité ou école supérieure
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Guangzhou Medical University Guangzhou Eighth Peoples' Hospital pays non établi dans la noticeUniversité ou école supérieure
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Foshan Fosun Chancheng Hospital pays non établi dans la noticeÉtablissement de santé
South China Research Center for Acupuncture and Moxibustion — Guangzhou University of Chinese Medicine, Guangzhou Eighth People's Hospital et Foshan Hospital of TCM, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.