Gary S. Krause

PKR-like endoplasmic reticulum kinase (PERK) activation following brain ischemia is independent of unfolded nascent proteins

Thomas H. Sanderson, Michael P. Deogracias, K.K. Nangia, Juncheng Wang et autres

us (code pays fourni par la source)

Hyperoxic Reperfusion after Global Cerebral Ischemia Promotes Inflammation and Long-Term Hippocampal Neuronal Death

Julie L. Hazelton, Irina S. Balan, Gregory I. Elmer, Tibor Kristián et autres

In this study we tested the hypothesis that long-term neuropathological outcome is worsened by hyperoxic compared to normoxic reperfusion in a rat global cerebral ischemia model. Adult male rats were anesthetized and subjected to bilateral carotid arterial occlusion plus bleeding hypotension for …

us (code pays fourni par la source)

Insulin activates the PI3K-Akt survival pathway in vulnerable neurons following global brain ischemia

Thomas H. Sanderson, Rita Kumar, Alina C. Murariu-Dobrin, Andrea B. Page et autres

UNLABELLED: Insulin is neuroprotective following transient global brain ischemia; however, the mechanisms by which insulin exerts its salutary effects remain unclear. OBJECTIVE: We assessed insulin's effect on the PI3K-Akt survival system and consequent modulation of the pro-apoptotic proteins Bim, Bad and FoxO3a. …

us (code pays fourni par la source)

Insulin blocks cytochrome c release in the reperfused brain through PI3‐K signaling and by promoting Bax/Bcl‐XL binding

Thomas H. Sanderson, Rita Kumar, Jonathon M. Sullivan, Gary S. Krause

The critical event of the intrinsic pathway of apoptosis following transient global brain ischemia is the release of cytochrome c from the mitochondria. In vitro studies have shown that insulin can signal specifically via phosphatidylinositol-3-OH-kinase (PI3-K) and Akt to prevent cytochrome c …

us (code pays fourni par la source)

Global brain ischemia and reperfusion

Brian J. O’Neil, Raymond C. Koehler, Robert W. Neumar, Uwe Ebmeyer et autres

Introduction Sudden, unexpected death claims nearly 1000 lives each day in the United States and is the fifth leading cause of all deaths in the western world. Cardiac arrest occurs over 300 000 times per year both in the United States and …

us, de (code pays fourni par la source)

Characterization of the eIF2-associated protein p67 during brain ischemia and reperfusion

Cheri R. Owen, C. Lipinski, Andrea B. Page, Blaine C. White et autres

OBJECTIVES: Within the first few minutes of reperfusion after global brain ischemia, there is a severe depression of protein translation owing to phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 (eIF2). There is a 67 kDa peptide (p67) that, in its …

us (code pays fourni par la source)

EMF-4

Rita Kumar, Thomas H. Sanderson, J Wright, Gary S. Krause

us (code pays fourni par la source)

Gene expression analysis of the development of congenital hydrocephalus in the H-Tx rat

Janet M. Miller, Rita Kumar, James Patterson McAllister, Gary S. Krause

us (code pays fourni par la source)

Thermogenesis and related metabolic targets for anti-obesity drugs

Jonathan R. S. Arch, Jochen Antel, Nick Finer, David J. Heal et autres

Gene alterations associated with closure of the cerebral aqueduct in hydrocephalic H-Tx rats

Janet M. Miller, James Patterson McAllister, Gary S. Krause

Materials and methods Midbrain regions which contain the cerebral aqueduct were micro-dissected from hydrocephalic and control animals at 5 days of age (n = 5). After RNA extraction and purification, total RNA was subjected to PCR techniques to generate cDNA that was …

us (code pays fourni par la source)

PERK is responsible for the increased phosphorylation of eIF2α and the severe inhibition of protein synthesis after transient global brain ischemia

Cheri R. Owen, Rita Kumar, Peichuan Zhang, Barbara C. McGrath et autres

Reperfusion after global brain ischemia results initially in a widespread suppression of protein synthesis in neurons that is due to inhibition of translation initiation as a result of the phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 (eIF2). To address the …

us (code pays fourni par la source)

Development, regulatory and marketing challenges for novel anti-obesity therapies.

DJ Heal, Elizabeth Jagger, Jochen Antel, Nick Finer et autres