Global brain ischemia and reperfusion
Rattachement africain : us, de. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction Sudden, unexpected death claims nearly 1000 lives each day in the United States and is the fifth leading cause of all deaths in the western world. Cardiac arrest occurs over 300 000 times per year both in the United States and Europe with the risk for persons 35 years and older estimated at 1 per 1000. In those patients resuscitated from cardiac arrest, nearly 60% die from a neurological cause. Despite every effort, only 3%–10% of all resuscitated patients are able to resume their former lifestyles. To date, there are no clinically effective pharmacologic tools for amelioration of brain damage by ischemia and reperfusion. Clinical trials conducted more than a decade ago utilizing postresuscitation treatment with barbiturates or calcium antagonists were disappointing. More recently, clinical treatment of stroke with a radical scavenger (trilazad), intercellular adhesion molecule-1 antagonist (Enlimomab), glutamate receptor antagonist (Aptiganel, gavestinel), glutamate release inhibitor (Lubeluzole), ganglioside administration (GM1), calcium channel blockade, or upregulation of the GABA receptor (Clomethiazole) were all found ineffective. This suggests that our understanding of the mechanisms involved in damage and repair in neurons remains incomplete and further therapeutic progress will require the delineation of the primary mechanisms involved in neuronal injury and repair. Although the picture is still incomplete, a few things are clear. The majority of damage occurs not during ischemia but during reperfusion. Nevertheless, the two processes work sequentially to increase neuronal damage (i.e., lipolysis during ischemia potentiates the radicalmediated peroxidation of polyunsaturated fatty acids (PUFAs) during reperfusion). […]
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Global brain ischemia and reperfusion
- Date Crossref
- 18/10/2007
- Éditeur
- Cambridge University Press
- Type
- book-chapter
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Beaumont Hospital Department of Emergency Medicine pays non établi dans la noticeÉtablissement de santé
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Johns Hopkins University Department of Anesthesiology pays non établi dans la noticeUniversité ou école supérieure
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University of Pennsylvania Department of Emergency Medicine pays non établi dans la noticeUniversité ou école supérieure
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Otto-von-Guericke-Universität Magdeburg pays non établi dans la noticeUniversité ou école supérieure
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Wayne State University Department of Emergency Medicine pays non établi dans la noticeUniversité ou école supérieure
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Klinik für Anaesthesiologie und Intensivtherapie pays non établi dans la noticeInstitution
Department of Emergency Medicine — Beaumont Hospital, Department of Anesthesiology — Johns Hopkins University et Department of Emergency Medicine — University of Pennsylvania, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.