A fully human pan VL9 HLA-E TCRm antibody enables functional dissection of HLA-E biology and checkpoint signaling
Soroush Ghaffari, Katherine Upchurch, Gizem Oter, Trivendra Tripathi et autres
0 citationsiScience
Jim Middelburg
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23Publications signalées
659Citations signalées
4Affiliations récentes
Institutions déclarées
Domaines associés
CAR-T cell therapy researchMonoclonal and Polyclonal Antibodies ResearchImmunotherapy and Immune ResponsesImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers
Publications récentes
The murine MHC-E molecule Qa-1b is surface displayed in a peptide-free conformation in homeostasis
Gaby Schaap, Soroush Ghaffari, Jim Middelburg, Marjolein Sluijter et autres
0 citationsFrontiers in Immunology
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes
Junyun Lai, Cheok Weng Chan, Jesse Armitage, Katherine M. Audsley et autres
5 citationsNature Immunology
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery
Amanda X. Y. Chen, Kah Min Yap, Joelle S. Kim, Kevin Sek et autres
77 citationsNature
Site-directed multivalent conjugation of antibodies to ubiquitinated payloads
Angela F. El Hebieshy, Zacharias Wijfjes, Camille M. Le Gall, Jim Middelburg et autres
6 citationsNature Biomedical Engineering
Improving CD3 bispecific antibody therapy in solid tumors using combination strategies
Katy A. Lloyd, Jim Middelburg, Vitalijs Ovcinnikovs, Nora Pencheva et autres
4 citationsFrontiers in Oncology
Cancer vaccines compensate for the insufficient induction of protective tumor-specific immunity of CD3 bispecific antibody therapy
Jim Middelburg, Gaby Schaap, Marjolein Sluijter, Katy A. Lloyd et autres
4 citationsJournal for ImmunoTherapy of Cancer
Myeloid effector cells in cancer
Pieter J. Schol, Marit J van Elsas, Jim Middelburg, Maarten K. Nijen Twilhaar et autres
33 citationsCancer Cell
Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy
Marit J van Elsas, Jim Middelburg, Camilla Labrie, Jessica Roelands et autres
155 citationsCancer Cell
T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors
Jim Middelburg, Marjolein Sluijter, Gaby Schaap, Büşra Göynük et autres
31 citationsNature Communications
The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent
Jim Middelburg, Soroush Ghaffari, Tom A. W. Schoufour, Marjolein Sluijter et autres
19 citationsCell Reports
Longitudinal evaluation of the biodistribution and cellular internalization of the bispecific CD3xTRP1 antibody in syngeneic mouse tumor models
Gerwin W. Sandker, Jim Middelburg, Evienne Wilbrink, Janneke D.M. Molkenboer‐Kuenen et autres
9 citationsJournal for ImmunoTherapy of Cancer
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