Accès ouvert
2026
article
OpenAlex
Codruța Claudia Gherman Lencu, Cezara-Andreea Gerdanovics, Olga Hilda Orasan, Ioana Iancu et autres
Bisphenols and phthalates are ubiquitous endocrine-disrupting chemicals with potential effects on reproductive neuroendocrine regulation, particularly during sensitive developmental windows. This review summarizes current evidence on their exposure profile, mechanisms of reproductive disruption, and female- and male-specific reproductive adversities. A structured narrative review …
ro
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2026
article
OpenAlex
Anamaria-Vlăduța Tomoiagă, Angela Cozma, Cezara-Andreea Gerdanovics, Alexandru Gerdanovics et autres
Iron is essential for normal cellular function, but its dysregulation is increasingly recognized as a key factor in colorectal tumorigenesis. This review provides an integrated overview of iron-related biomarkers across the full spectrum of colorectal neoplasia, from preneoplastic lesions to advanced colorectal …
ro
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2026
article
OpenAlex
Anamaria-Vlăduța Tomoiagă, S. Suciu, Cezara-Andreea Gerdanovics, Alexandru Gerdanovics et autres
Colorectal cancer (CRC) is a major global health burden characterized by progressive genetic and metabolic alterations, with iron metabolism being increasingly recognized as a key contributor to tumorigenesis. This review provides an integrated synthesis of current evidence on iron metabolism across the …
ro
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Accès ouvert
2025
article
OpenAlex
Bianca Mihaela Berechet, Olga Hilda Orasan, Vasile Negrean, Ioana Para et autres
Research undertaken over the past few years has brought attention to the role of oxidative stress in the development of neoplasms by damaging nucleic acids, lipids, and proteins, thereby altering their normal function. In general, the levels of antioxidant enzymes are low …
ro
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2025
review
OpenAlex
Teodora Alexescu, P. C. Alexander, Mirela-Georgiana Perné, Mircea Vasile Milaciu et autres
Background: Diabetes mellitus (DM) is a chronic metabolic disorder significantly associated with cardiovascular complications. Electrocardiographic (ECG) abnormalities are common in patients with type 2 diabetes (T2DM) and can serve as early markers for cardiovascular risk. Objective: This meta-analysis aims to evaluate the …
ro
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Accès ouvert
2024
article
OpenAlex
Raluca Ianoș, Mihaela Iancu, Călin Pop, Roxana Liana Lucaciu et autres
Background and Objectives: Heart failure (HF) is one of the most common initial presentations of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM). There are different cardiac biomarkers related to the pathophysiological mechanisms of HF in T2DM. The current …
ro
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2024
article
OpenAlex
Sorina Cezara Coste, Olga Hilda Orasan, Angela Cozma, Vasile Negrean et autres
(1) Background: Interleukin 17 (IL17) and toll-like receptor 4 (TLR4) elevate the risk of metabolic and liver diseases. (2) Methods: This study’s objective was to explore the association of IL17 and TLR4 gene polymorphisms with MASLD susceptibility and test their effect on …
ro
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2024
article
OpenAlex
Raluca Ianoș, Angela Cozma, Roxana Liana Lucaciu, Adriana Corina Hangan et autres
Type 2 diabetes mellitus (T2DM) is a metabolic disorder that has alarmingly increased in incidence in recent decades. One of the most serious complications of T2DM is diabetic cardiomyopathy (DCM), an often underrecognized yet severe condition that is a leading cause of …
ro
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Accès ouvert
2024
article
OpenAlex
Sorina Cezara Coste, Olga Hilda Orășan, Angela Cozma, Vasile Negrean et autres
Background: The pathogenesis of MASLD (metabolic dysfunction-associated steatotic liver disease) is driven by environmental, genetic, metabolic, immune, and inflammatory factors. IL-17 and TLR4 determine hepatic steatosis, inflammation, and finally fibrosis. Objectives: To explore the associations between the plasma levels of inflammatory markers, …
ro
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2024
article
OpenAlex
George Ciulei, Olga Hilda Orășan, Angela Cozma, Vasile Negrean et autres
(1) Colorectal cancer is a major cause of cancer-related death, with colorectal adenomas (CRAs) serving as precursors. Identifying risk factors such as vitamin D deficiency and the insulin-like growth factor (IGF) axis is crucial for prevention. (2) This case–control study included 85 …
ro
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2024
article
OpenAlex
George Ciulei, Olga Hilda Orășan, Angela Cozma, Vasile Negrean et autres
Vitamin D deficiency and type 2 diabetes mellitus are risk factors for colorectal cancer, suggesting a role for vitamin D receptor (VDR) and insulin receptor (INSR) gene polymorphisms. We investigated the prevalence of the VDR-BsmI (rs1544410) and NsiI A/G-INSR (rs2059806) polymorphisms and …
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Accès ouvert
2024
article
OpenAlex
Mirela-Georgiana Perné, Adela Sitar-Tăut, Olga Hilda Orasan, Vasile Negrean et autres
Colorectal cancer (CRC) is one of the most common neoplasms in developed countries, with increasing incidence and mortality, even in young people. A variety of serum markers have been associated with CRC (CEA, CA 19-9), but neither should be used as a …
ro
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