Zhixin Xie

Prostatic carcinoma with elevated carcinoembryonic antigen: a case report

Zhixin Xie, Aiming Yang, Qiang Wang

Carcinoembryonic antigen is a glycoprotein often associated with colorectal carcinoma but can also increase in other malignancies. We reported a rare case of prostate mucinous adenocarcinoma in a 69-year-old male with elevated carcinoembryonic antigen and normal prostate-specific antigen. The patient, with a …

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The role of hypothyroidism in cirrhosis pathogenesis: A retrospective cohort study and multi-omics integration analysis

Weixuan Liang, Qi Zhang, Can Weng, Hao Deng et autres

BACKGROUND: Liver cirrhosis is a progressive chronic disease with high morbidity and mortality, thereby posing a major challenge to global health. Evidence suggests that thyroid dysfunction, particularly hypothyroidism, is linked to liver diseases. Hypothyroidism disrupts metabolism, immune homeostasis, and inflammatory pathways, processes …

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Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches

Wang Nan, Weixuan Liang, Zhuofeng Wen, Wan‐Zhe Liao et autres

OBJECTIVE: To identify contraindicated medications and corresponding target genes for migraine and its subtypes. METHOD: Utilizing the Genome-Wide Association Studies (GWAS) for 14 medication-use categories from UK Biobank and GWAS for migraine and its subtypes from FinnGen, our study revealed potential contraindicated …

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Tu1410: SINGLE-CELL TRANSCRIPTOME ANALYSIS PROFILES CELLULAR AND MOLECULAR ALTERATIONS IN PANCREAS AND DUODENAL MUCOSA IN TYPE 1 AUTOIMMUNE PANCREATITIS

Yuheng Zhang, Zixiang Zhou, Zhixin Xie, Yunlu Feng et autres

Dual-Terminal Ion-Modulation Multiplier-Based Ion-Doped Stacked Semiconducting Nanosheets for Multifunctional Biomedical Applications

Baobao Xu, Yiyi Yang, Zhixin Xie, Haihua Xu

Stacked semiconducting nanosheets (SSNs), which feature strong in-plane covalent bonds but weak van der Waals (vdWs) interactions between adjacent layers, hold substantial promise in next-generation, printable, and flexible devices. Among them, SSN-based transistors with high current multiplication offer significant potential for large-area, …

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Critical role of Oas1g and STAT1 pathways in neuroinflammation: insights for Alzheimer’s disease therapeutics

Zhixin Xie, Linxi Li, Weizhong Hou, Zhongxi Fan et autres

BACKGROUND: Alzheimer's disease (AD) has a significant impact on an individual's health and places a heavy burden on society. Studies have emphasized the importance of microglia in the progression and development of AD. Interferon responses and Interferon-stimulated genes (ISGs) significantly function in …

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Proteome‐Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease

Chenhao Gao, Haobin Zhou, Wenpeng Liang, Zhuofeng Wen et autres

OBJECTIVE: To identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset and progression of Parkinson's disease (PD) through integrative proteomic and genetic analyses. METHOD: We utilized large-scale plasma and brain protein quantitative trait loci …

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Sex-specific associations of sex hormone binding globulin and risk of bladder cancer

Junyong Ou, Hai Bi, Haobin Zhou, Zhanyi Zhang et autres

Abstract Background Males have a three times higher risk of a diagnosis of bladder cancer (Bca) than females. Sex hormone-binding globulin (SHBG) may be associated with Bca risk. However, the sex-specific role of SHBG in Bca remains unclear. In this study, we …

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Solution-processed ambipolar ionic-gated transistors from 1D/2D heterojunctions of WSe2 and self-conversed SnO2/Se enabling high-sensitivity thermal sensing

Feng Li, Wenwen Chen, Baobao Xu, Yiyi Yang et autres

Ambipolar transistors from low-dimensional semiconductors with high charge-transporting capability and tunable bandgap have developed rapidly in functional applications, such as neuromorphic computing, lighting, storing, and sensing. However, there are still challenges to balance procedure complexity and device performance, such as current on–off …

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Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene: Hypotheses and conundrums

Zhixin Xie, Yue Li, Aiming Yang, Dong Wu et autres

Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a complex gastroenterological condition characterized by multiple ulcers in the small intestine with chronic bleeding and protein loss. This review explores the potential mechanisms underlying the pathogenesis of CEAS, focusing on the role …

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Gastroesophageal reflux disease with 6 neurodegenerative and psychiatric disorders: Genetic correlations, causality, and potential molecular mechanisms

Zhiqing Zhan, Ze-Min Huang, Haobin Zhou, Zhixin Xie et autres

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Association between Atopic Dermatitis and Colorectal Cancer: TET2 as a Shared Gene Signature and Prognostic Biomarker

Zhiqing Zhan, Ze-Min Huang, Ruiqi Zeng, Yuhua Luo et autres

Background: Recent studies have linked atopic dermatitis (AD) to colorectal cancer (CRC) risk.Their causality and potential molecular mechanisms remain unclear.Methods: We performed Mendelian randomization (MR) analysis to evaluate the causality between AD and CRC.Summary statistic data-based Mendelian randomization (SMR) analysis was used …

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