2025
conference-abstract
OpenAlex
Sybren L. N. Maas, Yiheng Tang, Eric Stutheit-Zhao, Ramin Rahmanzade et autres
Abstract Machine learning-based molecular classifications, particularly those using DNA methylation data, have greatly advanced diagnostics for meningioma, the most common type of primary intracranial tumor. Meningiomas have historically been classified into NF2-mutant and NF2-wild-type groups, while additional mutations and copy-number variations associated …
nl, de, ca, us, fr, gb, il, ch, at
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Leandro de Assis, Liyam Laraba, Jane E. Carré, Charles Affourtit et autres
Abstract AIMS Meningioma is the most common type of primary brain tumour, significantly impacting patients’ quality of life even after surgical intervention. While grade 1 meningiomas are classified as benign, some molecular sub- groups exhibit higher recurrence rates and resistance to conventional …
gb, de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Olivia Wakefield, David A. Hilton, Liyam Laraba, David Parkinson et autres
Abstract The Hippo signalling pathway is a tumour suppressive kinase cascade which results in phosphorylation and cytoplasmic sequestration of transcriptional coactivators YAP/TAZ. An upstream regulator of this pathway is Merlin, encoded for by the NF2 gene. Mutations in NF2 are characteristic of …
gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Sarah Boddy, Rebecca Simpson, Stephen J. Walters, Theresa Walsh et autres
Objective: Oral secretion problems are common yet poorly managed in people living with MND (plwMND). A validated patient-reported outcome for measuring saliva symptoms in this patient group would facilitate better monitoring of individuals. This study aimed to assess the validity, reliability and …
gb
(code pays fourni par la source)
2023
article
OpenAlex
L. Fertitta, Christina Bergqvist, Kavita Y. Sarin, Scott R. Plotkin et autres
BACKGROUND: Cutaneous neurofibromas (cNF) are considered one of the highest burdens of neurofibromatosis type 1 (NF1). To date, no medical treatment can cure cNF or prevent their development. In that context, there is an urgent need to prepare and standardize the methodology …
fr, us, au
(code pays fourni par la source)
Accès ouvert
2023
conference-abstract
OpenAlex
Maryam Shah, Matthew C. Banton, Claire Adams, Leandro de Assis et autres
Abstract AIMS Meningiomas are common primary intracranial tumours that arise from meninges. loss of chromosome 22q is common genetic event observed in meningiomas. About 50% of meningiomas harbour mutations in NF2 gene that resides on chromosome 22. Moreover, frequent mutations have been …
gb
(code pays fourni par la source)
Accès ouvert
2023
conference-abstract
OpenAlex
Sarah Kingdon, Agbolahan Sofela, Claire Adams, Oliver Hanemann
Abstract AIMS We aim to identify circulating prognostic biomarkers that accurately identify high risk meningioma whilst reducing the burden of invasive diagnostics. In our proteomic analysis, S100A4 and Fibulin-2 are significantly over expressed in grade 2 tumours compared to grade 1. They …
gb
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Yeasmin Akther, Claire Adams, Vikram Sharma, Claudia S. Barros et autres
Abstract Aims Meningioma is the most common primary intracranial tumour. Although ~80% are benign WHO grade I and show high rates of recurrence. Surgery is the main therapeutic approach, yet location can hamper complete resection and chemotherapies are ineffective. Moreover, accurate biomarkers …
gb
(code pays fourni par la source)
Accès ouvert
2021
conference-abstract
OpenAlex
Yeasmin Akther, Claire Adams, Vikram Sharma, Claudia S. Barros et autres
Abstract Introduction Meningioma are the most common primary intracranial tumour. According to WHO, ~80% tumours are benign grade I. Although, some grade I tumour clinically show aggressive behaviour. Radio-surgery are the main therapeutic approaches, chemotherapies are ineffective. Accurate biomarkers for clinical management …
gb
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Farshad Nassiri, Justin Z. Wang, Olivia Singh, Shirin Karimi et autres
BACKGROUND: There is a critical need for objective and reliable biomarkers of outcome in meningiomas beyond WHO classification. Loss of H3K27me3 has been reported as a prognostically unfavorable alteration in meningiomas. We sought to independently evaluate the reproducibility and prognostic value of …
ca, hk, it, us
(code pays fourni par la source)
Accès ouvert
2019
conference-abstract
OpenAlex
Agbolahan Sofela, Oliver Hanemann
Abstract Background With the increasing emphases on the integrated histo-pheno-genotypical diagnoses of central nervous system (CNS) tumours, there is a pressing need for the identification of biomarkers to aid in the clinical management, diagnosis, prognosis and follow-up of meningiomas too. WHO grade …
gb
(code pays fourni par la source)
Accès ouvert
2019
conference-abstract
OpenAlex
Daniele Baiz, Caterina Negroni, Emanuela Ercolano, Claire Adams et autres
Abstract Introduction Meningioma brain tumours are the most common primary tumour in adults. Despite surgery and/or radiation therapy, meningioma may recur. The 5-year recurrence rate in benign meningioma is estimated in about 10% while much greater in atypical and malignant tumours. MicroRNAs …
gb
(code pays fourni par la source)