Aidan Tirpack

Environmental Inequities and Pediatric Asthma Disparities

Zeni Scott, Nicole Koutlas, Aidan Tirpack, Kate Hoffman et autres

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Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis

Runci Wang, Anvita Singaraju, Kathryne E. Marks, Lorien Shakib et autres

Immune checkpoint inhibitor (ICI) therapies used to treat cancer, such as anti–PD-1 antibodies, can induce autoimmune conditions in some individuals. The T cell mechanisms mediating such iatrogenic autoimmunity and their overlap with spontaneous autoimmune diseases remain unclear. Here, we compared T cells …

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OP0015 CD38HI CYTOTOXIC CD8 T CELLS ARE EXPANDED FOLLOWING CHECKPOINT BLOCKADE AND CHARACTERIZE THE T CELL INFILTRATE IN CHECKPOINT INHIBITOR-ASSOCIATED ARTHRITIS

Anvita Singaraju, Kathryne E. Marks, R. Wang, L. Shakib et autres

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POS0402 CLONALLY EXPANDED CD38hi CYTOTOXIC CD8 T CELLS DEFINE THE T CELL INFILTRATE IN CHECKPOINT INHIBITOR-ASSOCIATED ARTHRITIS

R. Wang, Anvita Singaraju, Kathryne E. Marks, L. Shakib et autres

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Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis

Runci Wang, Anvita Singaraju, Kathryne E. Marks, Lorien Shakib et autres

Abstract Immune checkpoint inhibitor (ICI) therapies that promote T cell activation have improved outcomes for advanced malignancies yet also elicit harmful autoimmune reactions. The T cell mechanisms mediating these iatrogenic autoimmune events remain unclear. Here we assayed T cells from joints of …

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Higher Checkpoint Inhibitor Arthritis Disease Activity may be Associated With Cancer Progression: Results From an Observational Registry

Karmela K Chan, Aidan Tirpack, G. Vitone, Caroline Benson et autres

OBJECTIVE: To describe clinical features associated with cancer outcomes of patients with immune checkpoint inhibitor (ICI)-associated arthritis. METHODS: Observational study of patients with ICI-arthritis enrolled in a single-center registry. Arthritis phenotype and activity, medications, and cancer status were recorded at every visit. …

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Impact of COVID-19 on patients with rheumatic complications of cancer immunotherapy: results of a registry survey

Nilasha Ghosh, Aidan Tirpack, Karmela K Chan, Anne R. Bass

Immune checkpoint inhibitors (ICI) block negative regulatory molecules, such as CTLA-4, PD-1 and PD-L1, in order to mount an antitumor response. T cells are important for antiviral defense, but it is not known whether patients with cancer treated with ICI are more …

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OP0328 A UNIQUE PD1+CD38+ CD8+ T CELL POPULATION CHARACTERIZES CHECKPOINT INHIBITOR-ASSOCIATED INFLAMMATORY ARTHRITIS

Runci Wang, Karmela K Chan, Amy Cunningham‐Bussel, Laura T. Donlin et autres

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AB0183 EARLY RA PATIENTS SEEN IN PRACTICE WHO HAVE CO-EXISTENT NON-ARTICULAR PAIN HAVE SIGNIFICANT WORSENING OF PROMIS® 29 DOMAIN SCORES. RESULTS FROM THE CATCH US STUDY

V. Bykerk, Caroline Benson, G. Vitone, Aidan Tirpack et autres

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Impact of the SARS-CoV-2 Pandemic on a Cohort of Patients with Rheumatic Complications of Immune Checkpoint Inhibitors: A Registry Survey Study

Nilanjana Ghosh, Aidan Tirpack, Charlotte Benson, G. Vitone et autres

AB1079 CHECKPOINT INHIBITOR-ASSOCIATED ARTHRITIS: PHENOTYPES AND CYTOKINE ASSOCIATIONS

Karmela K Chan, G. Vitone, Sara Shanaj, Aidan Tirpack et autres

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