Janaka J. Karalliedde

The role of sex and ethnicity in the variability of estimated glomerular filtration rate ( eGFR ) in people with type 1 diabetes

Salma A. Ayis, Murat Ozdede, Luigi Gnudi, Thamer Alobaid et autres

Abstract Aims To examine sex‐based differences in estimated glomerular filtration rate (eGFR) trajectories for people with type 1 diabetes (T1D) over 10 years and to test the hypothesis that sex and ethnicity interaction predicts eGFR decline. Methods A cohort of 1495 individuals, …

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Are we closer to surpassing residual renal risk in type 2 diabetes?

Janaka J. Karalliedde

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The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes

Murat Özdede, Panagiotis Pavlou, Valson Krasniqi, Kleoniki I. Athanasiadou et autres

Abstract Aims/hypothesis Blood pressure variability (BPV) is a risk factor for kidney disease progression in hypertension and type 2 diabetes; however, the role of BPV in kidney disease in type 1 diabetes is unknown. The aim of this study was therefore to …

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An informatics-based data-led prioritization strategy to facilitate objective and equitable care for an ethnically diverse urban cohort of people with type 1 diabetes: A proof-of-concept study

Panagiotis Pavlou, Khuram Chaudhry, Ollie French, Sarah Keane et autres

Background Ethnicity and socioeconomic factors contribute to higher morbidity and mortality in people with type 1 diabetes (pwT1D), partly due to reduced access to specialised care and technology. Objectively prioritising high-risk individuals in resource-limited settings is challenging. Data-led prioritisation (DLP) uses health …

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Pharmacist-led optimization of modifiable cardiorenal risk factors in a neighbourhood-based diabetes clinic

Ciara Doherty, Shannon Garth, Anna Hodgkinson, Alice Rickford et autres

OBJECTIVES: To evaluate the impact of a specialist pharmacist on modifiable cardiorenal risk factors in a community diabetes clinic. METHODS: We retrospectively reviewed 246 people (54% male) with type 2 diabetes (T2D) from February 2023 to October 2023 (median follow-up of 6 …

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WCN26-8079 USING AUTOMATED INSULIN DELIVERY (‘ARTIFICAL PANCREAS’) FOR GLYCAEMIC MANAGEMENT IN PEOPLE WITH TYPE 1 DIABETES AND END STAGE KIDNEY DISEASE ON HAEMODIALYSIS

Panagiotis Pavlou, Lalantha Leelarathna, Thomas Johnston, Rebecca Hyslop et autres

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Impact of Body Mass Index Variability on Kidney Disease Progression in a Large Type 1 Diabetes Cohort

Murat Ozdede, Panagiotis Pavlou, Marta Avataneo, Stephen Thomas et autres

ABSTRACT Aims Body mass index (BMI) variability an index of ‘metabolic cycling’ predicts kidney disease in type 2 diabetes, but studies in people with type 1 diabetes (pwT1DM) are scarce. We examined the relationship between BMI variability and diabetic kidney disease (DKD) …

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Effect of lixisenatide on arterial stiffness in people with type 2 diabetes and kidney disease: Results of a randomised controlled trial

Nikolaos Fountoulakis, Panagiotis Pavlou, Dimitra Stathi, Aïcha Goubar et autres

OBJECTIVE: People with chronic kidney disease (CKD) and diabetes are at high risk of cardiovascular disease (CVD). Aortic pulse wave velocity (Ao-PWV) is an independent predictor of CVD. Cardiovascular outcome trials (CVOTs) with glucagon like peptide-1 receptor agonist (GLP-1 RA) class demonstrate …

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Type 1 diabetes, ageing and frailty: an underexplored intersection

Giuseppe Maltese, Janaka J. Karalliedde, Jugdeep Dhesi, Srikanth Bellary

Over recent decades, the life expectancy of individuals with type 1 diabetes has steadily improved due to advances in therapies that enhance metabolic control alongside better prevention and management of complications. However, this extended survival brings new challenges. Type 1 diabetes, through …

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Discordant real‐world glycaemic outcomes with Omnipod™ 5 and MiniMed™ 780G in adults with type 1 diabetes: Why validated measures matter

Panagiotis Pavlou, Ananthi Anandhakrishnan, Kleoniki I. Athanasiadou, Anna Brackenridge et autres

outcomes with Omnipod™ 5 and MiniMed™ 780G in

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Exocrine Pancreatic Insufficiency Manifesting Before Insulin Dependence in Adult‐Onset Type 1 Diabetes

Panagiotis Pavlou, Shrawan Pandit, Janaka J. Karalliedde

Exocrine pancreatic insufficiency may precede insulin dependence in adult-onset type 1 diabetes. Unexplained steatorrhea or weight loss in people with diabetes warrants further investigations including imaging of abdomen/pancreas, exocrine pancreatic function and diabetes antibody testing. Early recognition and multidisciplinary care lead to …

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Dialysis meets devices: the use of automated insulin delivery in end stage kidney disease and haemodialysis

Panagiotis Pavlou, Lalantha Leelarathna, Parizad Avari, Sufyan Hussain et autres

INTRODUCTION: Diabetes management in end-stage kidney disease (ESKD) presents unique challenges due to perturbations in renal physiology. ESKD influences the pharmacokinetics of insulin and glucose metabolism, while hemodialysis (HD) adds further complexity. There is an unmet need for adaptable therapies to help …

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