The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes
Rattachement africain : gb, tr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Aims/hypothesis Blood pressure variability (BPV) is a risk factor for kidney disease progression in hypertension and type 2 diabetes; however, the role of BPV in kidney disease in type 1 diabetes is unknown. The aim of this study was therefore to determine whether BPV has an impact on kidney disease progression in an ethnically diverse cohort of people with type 1 diabetes. Methods We studied 3079 people (median age 36 [range 18–85] years; 50% female; 78.5% White, 10.9% African Caribbean, 4.5% Asian, 6.1% Other) with type 1 diabetes and baseline eGFR >45 ml/min per 1.73m 2 attending two university hospital clinics between 2004 and 2018. BPV was assessed using visit-adjusted standard deviation (adj-SD), CV and average real variability (ARV) for systolic blood pressure (SBP) and diastolic blood pressure (DBP). The primary endpoint was eGFR decline of ≥50% from baseline with final eGFR <30 ml/min per 1.73m 2 , with death as a competing risk. Results Over a 14 year period, 272 people (8.8%) reached the primary endpoint. All BPV metrics for SBP and DBP were significantly associated with the primary endpoint. ARVs of SBP and DBP and African Caribbean ethnicity emerged as risk factors in multivariable analyses, independent of traditional risk factors, including baseline blood pressure, eGFR, HbA 1c , albuminuria and mean blood pressure in the exposure window. The strongest association was observed for the ARV of SBP (HR 1.54, 95% CI 1.27, 1.87, p <0.001). Conclusions/interpretation In people with type 1 diabetes, SBP and DBP variability are associated with kidney disease progression. Further studies are needed to investigate if BPV is a modifiable risk factor for kidney disease progression.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes
- Date Crossref
- 01/04/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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King's College London pays non établi dans la noticeUniversité ou école supérieure
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Hacettepe University pays non établi dans la noticeUniversité ou école supérieure
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Guy's and St Thomas' NHS Foundation Trust Department of Diabetes and Endocrinology pays non établi dans la noticeÉtablissement de santé
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King's College School pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Cardiovascular and Metabolic Medicine and Sciences pays non établi dans la noticeUniversité ou école supérieure
King's College London, Hacettepe University et Department of Diabetes and Endocrinology — Guy's and St Thomas' NHS Foundation Trust, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.