Zhiqiang Duan

Emodin inhibits Newcastle disease virus replication via regulating the phosphorylation levels of eEF2K/eEF2 and targeting viral N protein to reduce viral protein production

Wenjie Wu, Rongjing Xia, Si Ma, Zenglei Hu et autres

Newcastle disease (ND) caused by Newcastle disease virus (NDV) infection is a highly contagious avian disease that causes substantial threat to the global poultry industry. Emodin (EMO), a member of the free anthraquinone compounds derived from traditional Chinese medicines, is known for …

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Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform

Yiwei Zhang, Rufeng Fan, Lei Feng, Guoliang Wang et autres

High Resolution Image Download MS PowerPoint Slide DNA-encoded libraries (DELs) have emerged as an effective and efficient selection strategy for lead compound discovery in academia and industry over the past few decades. Despite recent advancements in this field, DEL remains limited by …

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Insights into the multifunctionality of viral glycoproteins F and HN in the lifecycle and pathogenesis of Newcastle disease virus: a systematic review

Si Ma, Wenjie Wu, Zhiqiang Duan

Newcastle disease virus (NDV) is a representative paramyxovirus that usually causes severe infections and substantial economic losses to the global poultry industry. Over the years, NDV has attracted widespread attention as a promising oncolytic virotherapy agent and vector vaccine against many pathogens …

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Advancements in the genomic feature of Newcastle disease virus and the multifaceted roles of non-structural proteins V/W in viral replication and pathogenesis

Guiying Leng, Zhiqiang Duan

As a prototype of paramyxovirus, Newcastle disease virus (NDV) is a highly contagious avian pathogen that usually causes substantial economic losses to the global poultry industry. Like other paramyxoviruses, the RNA genome of NDV can encode six structural proteins and two additional …

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Photochemical-Promoted Cross-Coupling Reaction of Alkyl Boronate Esters with DNA-Conjugated Aryl Bromides for DNA-Encoded Library Synthesis

Baiyang Mu, Yiwei Zhang, Xudong Wang, Rui Jin et autres

) content in compound collections for drug discovery, enhancing molecular diversity and offering a unique chemistry starting point. In this study, we report a mild, DNA-compatible, and off-DNA-inert photochemical cross-coupling reaction inspired by the amino radical transfer strategy. This method demonstrates broad …

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DNA-encoded Libraries with Covalent Warheads

Sixiu Liu, Rui Jin, Zhiqiang Duan, Xiaojie Lu

Currently, research on the application of covalent DNA-encoded compound libraries (covalent DELs, or CoDELs) is experiencing rapid growth, with numerous advancements and diverse applications. CoDELs provide several advantages over traditional discovery methods for discovering covalent inhibitors and have successfully overcome some of …

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Recent advancements in the diverse roles of polymerase-associated proteins in the replication and pathogenesis of Newcastle disease virus

Jinghang Zhou, Yuqi Duan, Menglan Liu, Jinyang Liu et autres

Newcastle disease virus (NDV) is a significant member of the Paramyxoviridae family, known for causing epidemics and substantial economic losses in the poultry industry worldwide. The NDV RNA genome primarily encodes six structural proteins (N, P, M, F, HN, and L) and …

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Chicken speckle-type POZ protein (SPOP) negatively regulates MyD88/NF-κB signaling pathway mediated proinflammatory cytokine production to promote the replication of Newcastle disease virus

Zhongming Meng, Yanbi Wang, Xianya Kong, Mona Cen et autres

The speckle-type POZ protein (SPOP) is demonstrated to be a specific adaptor of the cullin-RING-based E3 ubiquitin ligase complex that participates in multiple cellular processes. Up to now, SPOP involved in inflammatory response has attracted more attention, but the association of SPOP …

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Multifunctionality of matrix protein in the replication and pathogenesis of Newcastle disease virus: A review

Zhiqiang Duan, Qianyong Zhang, Menglan Liu, Zenglei Hu

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Identification and genetic evolution of E gene of a duck Tambusu virus isolated from southeast Guizhou Province

EJ An, Xiaoyu Luo, Dandan long, Hanhan Wang et autres

Abstract Since 2010, several strains of Duck Tembusu Virus (DTMUV) have been isolated from China. In autumn 2021, high mortality was observed in southwestern Guizhou Province, China, and a DTMUV strain named GZSS2022 was successfully isolated. After inoculation with SPF chicken embryos …

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Mutation of Basic Residues R283, R286, and K288 in the Matrix Protein of Newcastle Disease Virus Attenuates Viral Replication and Pathogenicity

Zhiqiang Duan, Haiying Shi, Jingru Xing, Qianyong Zhang et autres

The matrix (M) protein of Newcastle disease virus (NDV) contains large numbers of unevenly distributed basic residues, but the precise function of most basic residues in the M protein remains enigmatic. We previously demonstrated that the C-terminus (aa 264-313) of M protein …

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Machine Learning Design of Aluminum-Lithium Alloys with High Strength

Hongxia Wang, Zhiqiang Duan, Qingwei Guo, Yongmei Zhang et autres

Due to the large unexplored compositional space, long development cycle, and high cost of traditional trial-anderror experiments, designing high strength aluminum-lithium alloys is a great challenge. This work establishes a performance-oriented machine learning design strategy for aluminum-lithium alloys to simplify and shorten …

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