Ju‐Hyun An

Severe Hypernatraemia Secondary to Adipsia Associated With a Pituitary Macroadenoma in a Dog: A Case Report

Gyo-Bin Choo, Bum-Kyu Choi, Sooyoung Choi, Daji Noh et autres

BACKGROUND: Adipsia is a rare disorder characterised by absence of thirst despite hyperosmolality, resulting from dysfunction of the hypothalamic thirst centre. In veterinary medicine, most reported cases of adipsia are associated with congenital forebrain abnormalities, whereas acquired causes in adult dogs are …

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Comparative Circulating microRNA Profiling in Dogs with Pyometra and Other Inflammatory Diseases

Myeong-Seon Jeong, Gyo-Bin Choo, Bum-Kyu Choi, Mun-Ik Lee et autres

Circulating microRNAs (miRNAs) regulate inflammatory responses and have emerged as potential minimally invasive biomarkers of disease. However, comprehensive profiling of circulating miRNAs in naturally occurring inflammatory conditions in dogs remains limited. This study aimed to characterize circulating miRNA expression profiles using small …

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Idiopathic mediastinal chyloma in a cat: a case report of a novel manifestation of chyle leakage

Myeong-Seon Jeong, Mun-Ik Lee, Hyeong-Seok Oh, Ju‐Hyun An

BACKGROUND: Chyloma is a rare pseudocystic collection of chyle resulting from leakage of the thoracic duct or its branches. While sporadically reported in humans, it has not been previously described in veterinary medicine. This report describes the first case of an idiopathic …

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Extracellular vesicles from canine mammary tumor cells promote macrophage M2 polarization and enhance tumor progression

Na-Kyoung Chi, S. Kim, Ga‐Hyun Lim, Ki-Hoon Song et autres

Extracellular vesicles (EVs) derived from tumor cells play a crucial role in modulating and reprogramming the tumor microenvironment (TME), thereby promoting tumor progression. While previous studies have investigated the impact of tumor-derived EVs on macrophages in various cancers, such as bladder cancer …

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Extracellular Vesicles from Canine Mammary Tumor Cells Promote Macrophage M2 Polarization and Enhance Tumor Progression

Na-Kyoung Chi, Se-Hoon Kim, Ga‐Hyun Lim, Ki-Hoon Song et autres

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TSG6 affects anti cancer drug resistance and angiogenesis in 3D spheroid model of canine mammary gland tumor cells

Ga‐Hyun Lim, Ju‐Hyun An, Jeong‐Hwa Lee, Kyoungwon Seo et autres

TSG6 (Tumor necrosis factor stimulated gene-6) plays a critical role in modulating the tumor microenvironment by regulating inflammation, immune responses, and extracellular matrix remodeling. Hypoxia affects tumor growth, angiogenesis, and anti-cancer drug resistance in the tumor microenvironment, and TSG6 expression is known …

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Differential glycemic effects of DWP16001 in diabetic dogs according to baseline glycemic status: a multicenter randomized controlled trial

Ju‐Hyun An, Ben C.B. Ko, H. Namkung, Hyun‐Woo Lim et autres

BACKGROUND: Sodium-glucose cotransporter 2 inhibitors are widely used in human medicine for their insulin-independent glucose-lowering effects. However, their clinical efficacy and safety for managing diabetes mellitus in dogs have not been established. This study aimed to evaluate the efficacy and safety of …

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Glycated Albumin and Continuous Glucose Monitoring Metrics in Dogs with Diabetes Mellitus: A Pilot Study

Soon-Chan Kwon, Ju‐Hyun An, Dong-Hoo Kim, Hwa‐Young Youn

Diabetes mellitus (DM) is one of the most common endocrine disorders in dogs. Glycated albumin (GA), a biomarker of short-term glycemia, may offer a valuable tool for assessing glycemic control in dogs with DM. This pilot study evaluated the correlation between GA …

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Enhanced immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells in 3D culture

Eunbi Lee, Ga‐Hyun Lim, Ju‐Hyun An, Min‐Ok Ryu et autres

Introduction Mesenchymal stem cells (MSCs) have been introduced as a treatment for dogs owing to their immunomodulatory effects. In humans, 3D-cultured MSCs have recently been applied in treating various conditions, including myocardial infarction, liver disease, and kidney disease. This study aimed to …

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Evaluation of cognitive and mobility function in geriatric dogs following treatment with stem cell and stem cell extracellular vesicles derived from embryonic stem cells: a pilot study

Tae Yoon Kim, Namhee Kim, Jung Il Chae, Hyun Ju Oh et autres

Introduction Declining physical or mental health in older dogs can lead to changes in the dog's cognitive and musculoskeletal function. Regrettably, these degenerative changes cannot be remedied. In the present study, geriatric small dogs exhibiting cognitive and behavioral changes were treated with …

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Relationship Between Red Blood Cell Indices and Myxomatous Mitral Valve Disease in Small‐Breed Dogs: A Retrospective Study

Yunho Jeong, Ju‐Hyun An, Sooyoung Choi, Jin Young Chung et autres

BACKGROUND: Red blood cell (RBC) indices provide information on the size and haemoglobin content of erythrocytes. The RBC distribution width (RDW) is an index of size variability of the circulating RBC population. The correlation between various diseases and RDW in dogs has …

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Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system

Su-Min Park, Yong‐Hun Oh, Ga‐Hyun Lim, Ju‐Hyun An et autres

Microglia/macrophages participate in the development of and recovery from experimental autoimmune encephalomyelitis (EAE), and the macrophage M1 (pro-inflammatory)/M2 (anti-inflammatory) phase transition is involved in EAE disease progression. We evaluated the efficacy of crisdesalazine (a novel microsomal prostaglandin E2 synthase-1 inhibitor) in an …

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