Olivier Fléchelles

Seasonality of influenza virus, respiratory syncytial virus, rhinovirus and metapneumovirus in patients managed at a tertiary care hospital in Martinique (French Caribbean Island), 2016–2021

Moustapha Agossou, Sloane Rollier, Antoine Enfissi, Laurence Fagour et autres

Respiratory viruses show marked geographical variability in their temporal circulation, particularly in tropical settings where epidemiological data remain limited. Understanding local circulation patterns is essential to contextualize respiratory virus epidemiology outside temperate regions. We conducted a monocentric, hospital-based observational study including patients …

mq, gf, fr (code pays fourni par la source)

Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in France

Slim Fourati, Slim Fourati, Alawiya Reslan, Jérôme Bourret et autres

BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in infants. Nirsevimab, a long-acting monoclonal antibody targeting a conserved epitope on the prefusion F protein (site Φ), has shown high efficacy in clinical trials and early real-world …

fr, re, mq, nc (code pays fourni par la source)

Adverse fetal and perinatal outcomes associated with Zika virus infection during pregnancy: an individual participant data meta-analysis

Edna Acosta‐Pérez, Juan Aguilar Ticona, Jackeline Alger, Emily Ansusinha et autres

Background: Zika virus (ZIKV) infection during pregnancy is associated with an increased risk of congenital malformations. The prevalence of short and long-term consequences, however, remains uncertain due to heterogeneity across studies. Individual Participant Data Meta-Analysis (IPD-MA) offers an alternative approach to provide …

Adverse fetal and perinatal outcomes associated with Zika virus infection during pregnancy: an individual participant data meta-analysis

Edna Acosta Pérez, Juan Pablo Aguilar Ticona, Jackeline Alger, Celia Alpuche Aranda et autres

Background: Zika virus (ZIKV) infection during pregnancy is associated with an increased risk of congenital malformations. The prevalence of short and long-term consequences, however, remains uncertain due to heterogeneity across studies. Individual Participant Data Meta-Analysis (IPD-MA) offers an alternative approach to provide …

Impact of an early educational protocol on the oral language of children born preterm exhibiting phonological fragility: a multicenter randomized clinical trial

Aude Charollais, Vincent Laudenbach, Marie-Hélène Stumpf, B Delaporte et autres

We conducted a six-center, prospective, randomized, open-label trial to assess whether an early standardized educational protocol provided from 42 to 48 months of age improved the progression of oral language and phonological development in children born preterm. A total of 552 children …

mq, fr, ca (code pays fourni par la source)

Burden and seasonality of RSV bronchiolitis in hospitalized children on a French Caribbean island: Practical lessons from a 13‐year study

Olivier Fléchelles, Camille Oger, Aude Charollais, Moustapha Dramé et autres

Epidemiology of respiratory syncytial virus (RSV) bronchiolitis in the tropics is poorly understood, complicating the effective management of RSV epidemics. The main objective was to describe the seasonality of RSV bronchiolitis epidemics and the clinical characteristics of hospitalized infants over a 13-year …

fr, mq (code pays fourni par la source)

Description and outcomes of Afro-Caribbean children treated for multisystem inflammatory syndrome in the French West Indies

Charlène Grabot, Mélanie Brard, Daphnée Hilaire, Moustapha Dramé et autres

Introduction: Several studies have reported a higher frequency and greater morbidity and mortality of multisystem inflammatory syndrome in children (MIS-C) of black African descent. Objectives: We aimed to describe the clinical, laboratory and echocardiographic characteristics as well as outcomes of children with …

mq, gp, fr (code pays fourni par la source)

Evaluation of the SIMULRESP: A simulation software of child and teenager cardiorespiratory physiology

David Brossier, Olivier Fléchelles, Michaël Sauthier, Catherine Engert et autres

Abstract Background Mathematical models based on the physiology when programmed as a software can be used to teach cardiorespiratory physiology and to forecast the effect of various ventilatory support strategies. We developed a cardiorespiratory simulator for children called “SimulResp.” The purpose of …

fr, ca, mq (code pays fourni par la source)

Consequences of In Utero Zika Virus Exposure and Adverse Pregnancy and Early Childhood Outcomes: A Prospective Cohort Study

Rebecca Grant, Olivier Fléchelles, Narcisse Elenga, B. Tressières et autres

We aimed to describe adverse pregnancy outcomes among women who had symptomatic, RT-PCR-confirmed ZIKV infection and early childhood outcomes among their infants. We enrolled pregnant women with symptomatic, RT-PCR-confirmed ZIKV infection in a prospective cohort study, and their infants in a prospective …

fr, mq, gf, gp (code pays fourni par la source)

Fundus Changes in the Offspring of Mothers With Confirmed Zika Virus Infection During Pregnancy in French Guiana, Guadeloupe, and Martinique, French West Indies

H. Merle, Maxime Chassery, Laurence Beral, Fatiha Najioullah et autres

Importance: Most ocular lesions have been described for children with congenital Zika syndrome. The frequency of finding ocular abnormalities is unknown among children exposed to Zika virus (ZIKV) during pregnancy. This study was conducted on newborns whose mothers were positive for ZIKV, …

mq, gp, fr (code pays fourni par la source)

Evaluation of the SIMULRESP: a simulation software of child and teenager cardiorespiratory physiology

David Brossier, Olivier Fléchelles, Michaël Sauthier, Catherine Engert et autres

BACKGROUND: Mathematical models based on the physiology when programmed as a software can be used to teach cardiorespiratory physiology and to forecast the effect of various ventilatory support strategies. We developed a cardiorespiratory simulator for children called “SimulResp”. The purpose of this …

ca, mq, fr (code pays fourni par la source)

Multisystem Inflammatory Syndrome in Children by COVID-19 Vaccination Status of Adolescents in France

Michaël Levy, Morgan Recher, Hervé Hubert, Étienne Javouhey et autres

International audience

fr, mq (code pays fourni par la source)