Fundus Changes in the Offspring of Mothers With Confirmed Zika Virus Infection During Pregnancy in French Guiana, Guadeloupe, and Martinique, French West Indies
Rattachement africain : mq, gp, fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Importance: Most ocular lesions have been described for children with congenital Zika syndrome. The frequency of finding ocular abnormalities is unknown among children exposed to Zika virus (ZIKV) during pregnancy. This study was conducted on newborns whose mothers were positive for ZIKV, confirmed with reverse-transcription polymerase chain reaction (RT-PCR) testing. Objective: To report ocular fundus manifestations in newborns with congenital ZIKV exposure in French Guiana, Martinique, and Guadeloupe, French West Indies, to assess its prevalence. Risk factors, such as the presence of extraocular fetopathies and the gestational term at infection, were sought. Design, Setting, and Participants: This was a cross-sectional multicentric study, conducted from August 1, 2016, to April 30, 2019, for which data were collected prospectively. The study inception was at the beginning of 2016 from the onset of the ZIKV epidemic in the French West Indies. Newborns whose mothers tested positive (by RT-PCR) for ZIKV during pregnancy were included. Interventions: Fundus examination was performed using widefield retinal imaging after pupil dilation. Infection date, delivery mode, and newborn measurements were collected. Main Outcomes and Measures: Anomalies of the vitreous, choroid, retina, and optic disc. Results: A total of 330 children (mean [SD] age, 68 [IQR, 22-440] days; 170 girls [51.5%]) were included. Eleven children (3.3%) had perivascular retinal hemorrhages, and 3 (0.9%) had lesions compatible with congenital ZIKV infection: 1 child had torpedo maculopathy, 1 child had a chorioretinal scar with iris and lens coloboma, and 1 child had a chorioretinal scar. Retinal hemorrhages were found at childbirth during early screening. Lesions compatible with congenital ZIKV infection were not associated with the presence of extraocular fetopathy. Microcephaly was not associated with lesions compatible with congenital ZIKV infection (odds ratio [OR], 9.1; 95% CI, 0.8-105.3; P = .08), but severe microcephaly was associated with an OR of 81 (95% CI, 5.1-1297.8; P = .002). Conclusions and Relevance: Results of this cross-sectional study suggest that the ocular anomalies found may be associated with ZIKV in 0.9% of the exposed population. Ocular lesions were rare, affected mostly the choroid and retina, and seemed to be associated with choroiditis-related scarring that developed during fetal growth.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Fundus Changes in the Offspring of Mothers With Confirmed Zika Virus Infection During Pregnancy in French Guiana, Guadeloupe, and Martinique, French West Indies
- Date Crossref
- 01/10/2022
- Éditeur
- American Medical Association (AMA)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Centre Hospitalier Universitaire de Martinique pays non établi dans la noticeÉtablissement de santé
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Institut Pasteur de la Guadeloupe Emerging Diseases Epidemiology Unit pays non établi dans la noticeStructure de recherche
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Inserm pays non établi dans la noticeOrganisme public
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Université de Montpellier pays non établi dans la noticeUniversité ou école supérieure
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Université Paris Cité pays non établi dans la noticeUniversité ou école supérieure
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Centre hospitalier national d'ophtalmologie des Quinze-Vingts Department of Ophthalmology pays non établi dans la noticeÉtablissement de santé
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Sorbonne Université pays non établi dans la noticeUniversité ou école supérieure
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Université Pierre-et-Marie-Curie pays non établi dans la noticeUniversité ou école supérieure
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Institut Pasteur pays non établi dans la noticeOrganisation à but non lucratif
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University Hospital of Martinique Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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University Hospital of Guadeloupe Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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University of Montpellier Department of Pathogenesis and Control of Chronic and Emerging Infections pays non établi dans la noticeUniversité ou école supérieure
Centre Hospitalier Universitaire de Martinique, Emerging Diseases Epidemiology Unit — Institut Pasteur de la Guadeloupe et Inserm, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.