Pál Riba

Do vitamins halt the COVID-19-evoked pro-inflammatory cytokines involved in the development of neuropathic pain?

Mahmoud Al‐Khrasani, Nariman Essmat, Imre Boldizsár, B Varga et autres

Neuropathic pain (NP), a disease affecting the somatosensory nervous system, causes a high socioeconomic burden on healthcare systems and society; yet, its management has not been fully solved. Post COVID-19, with sequelae of the somatosensory system, further increases the number of individuals …

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Glycine Transporter 1 Inhibitors Minimize the Analgesic Tolerance to Morphine

Anna Rita Galambos, Nariman Essmat, Péter P. Lakatos, Edina Szűcs et autres

Opioid analgesic tolerance (OAT), among other central side effects, limits opioids' indispensable clinical use for managing chronic pain. Therefore, there is an existing unmet medical need to prevent OAT. Extrasynaptic N-methyl D-aspartate receptors (NMDARs) containing GluN2B subunit blockers delay OAT, indicating the …

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Gyógyszer-interakciók időskorban, a kombinált gyógyszeres kezelés kihívásai, Beers-lista

Pál Riba, Anikó Görbe, Péter Ferdinandy

Az evidenciaalapú orvoslás alapvető módszerei közé tartozik a gyógyszeres terápia. A 2005. évi XCV. törvény szerin gyógyszernek nevezett „bármely anyag vagy azok keveréke, amelyet emberi betegségek megelőzésére vagy kezelésére alkalmazható termékként jelenítenek meg, vagy azok az anyagok vagy keverékei, amelyek farmakológiai, immunológiai …

Pregabalin–Tolperisone Combination to Treat Neuropathic Pain: Improved Analgesia and Reduced Side Effects in Rats

Nariman Essmat, Anna Rita Galambos, Péter P. Lakatos, Dávid Árpád Karádi et autres

The current treatment of neuropathic pain (NP) is unsatisfactory; therefore, effective novel agents or combination-based analgesic therapies are needed. Herein, oral tolperisone, pregabalin, and duloxetine were tested for their antinociceptive effect against rat partial sciatic nerve ligation (pSNL)-induced tactile allodynia described by …

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Telmisartan Is a Promising Agent for Managing Neuropathic Pain and Delaying Opioid Analgesic Tolerance in Rats

Dávid Árpád Karádi, Anna Rita Galambos, Péter P. Lakatos, Joost Apenberg et autres

Despite the large arsenal of analgesic medications, neuropathic pain (NP) management is not solved yet. Angiotensin II receptor type 1 (AT1) has been identified as a potential target in NP therapy. Here, we investigate the antiallodynic effect of AT1 blockers telmisartan and …

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Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain

Kornél Király, Dávid Árpád Karádi, Ferenc Zádor, Amir Mohammadzadeh et autres

The current protocols for neuropathic pain management include µ-opioid receptor (MOR) analgesics alongside other drugs; however, there is debate on the effectiveness of opioids. Nevertheless, dose escalation is required to maintain their analgesia, which, in turn, contributes to a further increase in …

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Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model

Amir Mohammadzadeh, Péter P. Lakatos, Mihály Balogh, Ferenc Zádor et autres

The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. We aimed to study …

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On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance

Susanna Fürst, Zoltán Zádori, Ferenc Zádor, Kornél Király et autres

There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is well recognized. Unfortunately, …

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Comparisons of In Vivo and In Vitro Opioid Effects of Newly Synthesized 14-Methoxycodeine-6-O-sulfate and Codeine-6-O-sulfate

Ferenc Zádor, Amir Mohammadzadeh, Mihály Balogh, Zoltán Zádori et autres

The present work represents the in vitro (potency, affinity, efficacy) and in vivo (antinociception, constipation) opioid pharmacology of the novel compound 14-methoxycodeine-6-O-sulfate (14-OMeC6SU), compared to the reference compounds codeine-6-O-sulfate (C6SU), codeine and morphine. Based on in vitro tests (mouse and rat vas …

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Efficacy-Based Perspective to Overcome Reduced Opioid Analgesia of Advanced Painful Diabetic Neuropathy in Rats

Mihály Balogh, Ferenc Zádor, Zoltán Zádori, Mohammed Shaqura et autres

Reduction of the opioid analgesia in diabetic neuropathic pain (DNP) results from µ-opioid receptor (MOR) reserve reduction. Herein, we examined the antinociceptive and antiallodynic actions of a novel opioid agonist 14-O-methymorphine-6-O-sulfate (14-O-MeM6SU), fentanyl and morphine in rats with streptozocin-evoked DNP of 9-12 …

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Similarity and dissimilarity in antinociceptive effects of dipeptidyl-peptidase 4 inhibitors, Diprotin A and vildagliptin in rat inflammatory pain models following spinal administration

Mihály Balogh, Bence Kálmán Varga, Dávid Árpád Karádi, Pál Riba et autres

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The Peripheral Versus Central Antinociception of a Novel Opioid Agonist: Acute Inflammatory Pain in Rats

Mihály Balogh, Zoltán Zádori, Bernadette Lázár, Dávid Árpád Karádi et autres

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