A. Crellin

The National Referral Service for Proton Beam Therapy in England: A Journey Towards Equitable Access

Simona Gaito, Anna France, Y. Wang, Marianne Aznar et autres

AIM: Health care policies have frequently centred on ensuring equitable access within diverse populations. While new technologies have immense potential for improving health outcomes, they may not be necessarily available across varied geographical areas and socioeconomic backgrounds. The goal of this study …

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Surgical management of skull base chordomas and chondrosarcomas: insights from a national cohort study

Laurence Glancz, Cathal John Hannan, Alexandros Vyziotis, Gillian Potter et autres

Objective: Skull base chordoma and chondrosarcoma are distinct sarcomas of the skull base but share significant therapeutic challenges due to their proximity to critical neurovascular structures, making surgical resection difficult. We sought to establish factors associated with outcome predictors in a national …

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1582: A National Referral Service for Proton Beam Therapy: a journey towards equitable access.

Simona Gaito, Anna France, Marianne Aznar, Gillian Whitfield et autres

Equity of Access to Proton Beam Therapy in England: A National NHS analysis

Simona Gaito, Anna France, M. Aznar, A. Crellin et autres

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Proton Beam Therapy in the Reirradiation Setting of Brain and Base of Skull Tumour Recurrences

Simona Gaito, N.G. Burnet, Marianne Aznar, Giulia Marvaso et autres

The therapeutic management of local tumour recurrence after a first course of radical radiotherapy is always complex. Surgery and reirradiation carry increased morbidity due to radiation-induced tissue changes. Proton beam therapy (PBT) might be advantageous in the reirradiation setting, thanks to its …

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Assessing Equity of Access to Proton Beam Therapy: A Literature Review

Simona Gaito, Marianne Aznar, N.G. Burnet, A. Crellin et autres

Proton beam therapy (PBT) is one of the most advanced radiotherapy technologies, with growing evidence to support its use in specific clinical scenarios and exponential growth of demand and capacity worldwide over the past few decades. However, geographical inequalities persist in the …

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Proton Beam Therapy in the Oligometastatic/Oligorecurrent Setting: Is There a Role? A Literature Review

Simona Gaito, Giulia Marvaso, Ramón Ortiz, A. Crellin et autres

BACKGROUND: Stereotactic ablative radiotherapy (SABR) and stereotactic radiosurgery (SRS) with conventional photon radiotherapy (XRT) are well-established treatment options for selected patients with oligometastatic/oligorecurrent disease. The use of PBT for SABR-SRS is attractive given the property of a lack of exit dose. The …

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Outcomes of Patients Treated in the UK Proton Overseas Programme: Non-central Nervous System Group

Eunji Hwang, Simona Gaito, Anna France, A. Crellin et autres

AIMS: The UK Proton Overseas Programme (POP) was launched in 2008. The Proton Clinical Outcomes Unit (PCOU) warehouses a centralised registry for collection, curation and analysis of all outcomes data for all National Health Service-funded UK patients referred and treated abroad with …

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Outcomes of Patients Treated in the UK Proton Overseas Programme: Central Nervous System Group

Simona Gaito, Eunji Hwang, Anna France, Marianne Aznar et autres

AIMS: In 2008, the UK National Health Service started the Proton Overseas Programme (POP), to provide access for proton beam therapy (PBT) abroad for selected tumour diagnoses while two national centres were being planned. The clinical outcomes for the patient group treated …

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Developing a National Infrastructure for Proton Beam Therapy Trials

R. Rieu, A. Crellin, David Thomson, Christopher M. Nutting

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Estimating the percentage of patients who might benefit from proton beam therapy instead of X-ray radiotherapy

N.G. Burnet, T. Mee, Simona Gaito, N.F. Kirkby et autres

OBJECTIVES: High-energy Proton Beam Therapy (PBT) commenced in England in 2018 and NHS England commissions PBT for 1.5% of patients receiving radical radiotherapy. We sought expert opinion on the level of provision. METHODS: Invitations were sent to 41 colleagues working in PBT, …

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Normal Tissue Complication Probability Modelling for Toxicity Prediction and Patient Selection in Proton Beam Therapy to the Central Nervous System: A Literature Review

Simona Gaito, N.G. Burnet, Marianne Aznar, A. Crellin et autres

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