Ramón Ortiz

An ion treatment planning framework for inclusion of nanodosimetric ionization detail through cluster dose

Simona Facchiano, Ramón Ortiz, Remo Cristoforetti, J Naoki D-Kondo et autres

Abstract Background Nanodosimetry relates the cumulative or statistical moments of Ionization Detail (ID) with biological endpoints of relevance to cancer radiotherapy using charged particles. This association suggests to develop an additional physics‐detailed layer of modeling that may complement biological modeling and treatment …

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Minibeam radiation therapy does not induce canonical immunogenic cell death or cGAS–STING activation in glioblastoma and astrocyte monocultures

Annaïg Bertho, Sarah Potiron, Ramón Ortiz, Angela Corvino et autres

Minibeam Radiation Therapy (MBRT) uses sub-millimetric beams to generate highly heterogeneous dose distributions and has shown promising results in preclinical glioblastoma by preserving normal tissue while eliciting immune responses. However, the initiating molecular mechanisms remain unclear. We hypothesised that immunogenic cell death …

fr, es (code pays fourni par la source)

FRAMEWORK AND MONTE CARLO VALIDATION OF AN ION TREATMENT PLANNING TOOL EMPLOYING CLUSTER DOSE

Simona Facchiano, Ramón Ortiz, Naoki Kondo, Remo Cristoforetti et autres

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CLUSTER DOSE AS A NEW PARADIGM FOR PROTON AND ION THERAPY TREATMENT PLANNING BASED ON NANODOSIMETRIC QUANTITIES

Ramón Ortiz, José Ramos‐Méndez, Jian‐Hua Mao, Ivana Đokić et autres

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A refined approach to compute nanodosimetric quantities for proton and ion radiotherapy treatment planning

Ramón Ortiz, José Ramos‐Méndez, J Naoki D-Kondo, Bruce Faddegon

Abstract Objective . To present a refined approach to calculate a database of nanodosimetric quantities and efficiently and accurately compute voxel-averaged ionization detail (ID) quantities for particle radiotherapy treatment planning (RTP) applications. Approach . Monte Carlo track structure was employed to compute …

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Figure S10 from Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma

Lorea Iturri, Miriam Riquelme‐Perez, Pierre‐Emmanuel Bonté, Sarah Potiron et autres

Figure S10. Removal of contaminant in T cell subclustering. A) Reclustering of clusters C13-C17 of Fig. 5. B) Heatmap of top 10 most significantly differentially expressed genes per cluster. C) Expression of macrophage markers in the clusters confirms contamination, cluster 3 will …

Figure S1 from Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma

Lorea Iturri, Miriam Riquelme‐Perez, Pierre‐Emmanuel Bonté, Sarah Potiron et autres

Figure S1. Survival curves of RG2- glioma bearing rats: non-irradiated controls (black), rats receiving 30 Gy in Conv-PT (blue) and rats receiving 30 Gy average dose in pMBRT (red). The survival of the irradiated groups is significantly longer than the controls (p …

Data from Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma

Lorea Iturri, Miriam Riquelme‐Perez, Pierre‐Emmanuel Bonté, Sarah Potiron et autres

Abstract Treating radioresistant tumors like glioblastoma multiforme remains a challenge exacerbated by their immunosuppressive nature. Radiotherapy (RT) plays an immunomodulatory role, exerting both immunosuppressive and immunostimulatory effects. The nature of these effects depends on the total dose, dose per fraction, dose delivery …

Figure S2 from Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma

Lorea Iturri, Miriam Riquelme‐Perez, Pierre‐Emmanuel Bonté, Sarah Potiron et autres

Figure S2. A Gating strategy for tumor immune cell analysis by flow cytometry in Fig. 2.

Figure S11 from Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma

Lorea Iturri, Miriam Riquelme‐Perez, Pierre‐Emmanuel Bonté, Sarah Potiron et autres

Figure S11. Heatmap showing the top 10 differentially expressed genes per cluster in the NK/T cell object

Figure S4 from Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma

Lorea Iturri, Miriam Riquelme‐Perez, Pierre‐Emmanuel Bonté, Sarah Potiron et autres

Figure S4. Representative images from the IF mutliplex

Figure S6 from Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma

Lorea Iturri, Miriam Riquelme‐Perez, Pierre‐Emmanuel Bonté, Sarah Potiron et autres

Figure S6. Heatmap showing the top 5 differentially expressed genes in the clusters