Alison Epstein Ringel

Figure S5 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 5

Figure S1 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 1

Figure S7 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 7

Figure S4 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 4

Figure S2 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 2

Figure S6 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 6

Figure S3 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 3

Figure S8 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 8

Citrate Compartmentalization Controls Calcium-Dependent Cytokine Production in Effector T Cells

Andrea L Cote, Claire McIntyre, Joshua A. Acklin, Lillian R. Delacruz et autres

T cells couple cytokine production to glucose availability. Under glucose-replete conditions, citrate transport from the mitochondria to the cytosol by the citrate carrier SLC25A1 suppresses calcium-dependent transcription factor activity in effector T cells. Either reducing glucose availability or blocking the exchange of …

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Abstract 2099: Iron supplementation rescues anemia of chronic disease in pancreatic ductal adenocarcinoma.

Yichi (Tony) Zhang, Cindy Pyo, Anna M. Barbeau, Davey Feng et autres

Abstract Pancreatic cancer is a devastating malignancy that is rising in incidence and has nearly universal poor outcomes. We find rates of iron deficiency are high in pancreatic cancer patients and track with the high prevalence of anemia in these patients. From …

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Systems analysis reveals alternate metabolic states adopted by Mycobacterium tuberculosis across species

Jonathan Padilla‐Gómez, Rachel A. McGinn, Kendra A. Libby, Alison Epstein Ringel et autres

(Mtb) persists within macrophages, yet how different host species shape bacterial state remains poorly understood. Here, we directly compared the intracellular transcriptome of Mtb during infection of human and mouse macrophages, revealing distinct host-imposed microenvironments that drive the pathogen into separable metabolic …

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FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis

Liling Xu, Maria Bottermann, Paula Maldonado Villavicencio, John E. Warner et autres

Little is known about the role of autophagy in the human humoral immune system. Here, we found that in B cells, genetic ablation of FIP200, a mammalian metabolic sensor that regulates autophagy in response to a range of stimuli, led to diminished …

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