Keita Ogawa

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling

Keita Ogawa, Takahiro Aoki, Tatsuya Kaneko, Hongxuan Wang et autres

ABSTRACT Psychological stress has long been implicated in cancer progression, yet the underlying biological pathways remain incompletely understood. In particular, the influence of stress on myeloid cells remains poorly explored. Here, we demonstrate that restraint stress accelerates hepatocellular carcinoma (HCC) progression through …

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Promoting the Effective Utilization of Timber Resources

Keita Ogawa

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Effect of Staggered Joint Arrangement on Shear Performance of Drift Pin Joints with Slotted-in Steel Plates Using Sugi Glulam

Kenji Kobayashi, Keita Ogawa

鋼板挿入ドリフトピン接合において，ドリフトピンの千鳥状配置は接合部サイズの縮小化につながり得る。そのためには，脆性的な挙動を示さないための千鳥配置条件を明らかにする必要がある。本研究では，様々なドリフトピンの配置間隔の下で二面せん断試験を行い，靭性的な挙動を示す千鳥幅と接合具間隔の組み合わせを明らかにした。例えば，接合具間隔が接合具径の6倍以上であれば靭性的な挙動が見られ，5倍の場合では千鳥幅が小さい条件で脆性的な挙動が見られた。3.5倍の場合では，千鳥幅によらずいずれも脆性的となった。また，平面座標上の楕円を用いて配置条件の数値化を試みており，変形性能を簡易的に保証する方法を提案した。この知見は，接合部設計に有用と考える。

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Anti-tumor effect of intratumoral administration of induced pluripotent stem cell-derived NKT cells on glioblastoma through CD155/DNAM-1 interaction

Ko Ozaki, Takahiro Aoki, Masayoshi Kobayashi, Mariko Takami et autres

BACKGROUND: Glioblastoma is the most malignant brain tumor with the poorest prognosis, but there have been no significant therapeutic advances in the past 20 years. Intratumoral administration of invariant natural killer T (iNKT) cells for glioblastoma has recently been reported and is …

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EFFECT OF DIFFERENT JOINING METHODS ON SKIDDING DEFORMATION OF DIAGONAL MEMBER BY DIAGONAL AXIAL LOAD IN SAWN TIMBER TRUSS : MECHANICAL ANALYSIS USING SPRING MODEL

Kenji Kobayashi, Keita Ogawa

This study attempted to clarify the sliding behavior that occurs at the diagonal joints of wooden truss beams. Specimens were created in which the diagonal members, bottom chord members, and beams were joined in different ways, and diagonal member axial load tests …

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MEGF6 knockdown ameliorates lenvatinib-induced muscle differentiation suppression and enhances the antitumor effect of lenvatinib on hepatocellular carcinoma

Na Qiang, Junjie Ao, Masato Nakamura, Jiaqi Zhang et autres

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Antibody‐Dependent Cellular Cytotoxicity of iPS Cell‐Derived Natural Killer T Cells by Anti‐ GD2 mAb for Neuroblastoma

Katsuhiro Nishimura, Takahiro Aoki, Midori Kobayashi, Mariko Takami et autres

While antibody-dependent cellular cytotoxicity (ADCC) by anti-disialoganglioside GD2 monoclonal antibody (mAb) has succeeded in increasing the survival rate of high-risk patients with neuroblastoma, approximately 40%-50% of patients die from the disease. Recently, we developed induced pluripotent stem cell-derived natural killer T (iPS-NKT) …

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DIFFERENCE IN MECHANICAL PROPETIES DUE TO INHIBITION TECHNIQUES OF FRICTION APPLIED TO LATERAL TESTS OF TIMBER JOINTS

Keita Ogawa, Kenji Kobayashi

COMPARISON OF CYCLIC LOADING PROTOCOLS AND CYCLIC BENDING PERFORMANCES OF SELF-TAPPING SCREWS

Kenji Kobayashi, Keita Ogawa

A DISCUSSION OF EVALUATION METHODS FOR SPLITTING AND SHEAR FAILURE BY CURRENT STANDARD EQUATIONS FOR DRIFT-PINED JOINT WITH INSERTED PLATE AT THE END OF GLULAM-BEAM

Wataru KAMBE, Kento Suzuki, Yo OCHIAI, Atsuo Takino et autres

We conducted loading tests using steel plate-inserted joints with drift pins at the beam ends of glulam beams. The ultimate strength formulas for these joints are the splitting and shear resistance, but their applicability is unclear.

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Quantitative evaluation of problem-based learning outcomes on student pharmacists’ patient care process in Japan

Masakazu Hirose, Keita Ogawa, Hiroyuki Yamashita, Nobuhiro Nagasaki et autres

Background: This study aimed to evaluate the learning effects of problem-based learning (PBL) by quantitatively comparing the medication management abilities of PBL practitioners (the PBL group) and non-practitioners (the non-PBL group) among pharmacy students in Japan. Methods: An outpatient-based pharmacy practice simulation …

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A Novel Parameter for Representing Bending Performance of Wood with One Value

Keita Ogawa, Kenji Kobayashi, Wataru Kanemoto

木材の曲げ強度性能は力学試験を実施すると調べることができ，その際に曲げヤング率や曲げ強度等は一般的に用いられる。これらの特性値は専門家にとっては基本的な知識であるものの，いずれも高等教育機関等で学習する内容である。現在は地域の森林を活性化するために地域の人々が木材の強度性能を知ろうとする機会があるが，そこで示される試験結果は，必ずしも非専門家にとって容易に理解できるものではない。一方，他の業界では，様々なモニタリング結果を一数値に縮約した指標を提示し，非専門家であっても値の大小の比較で状況判断できる工夫が見られる。そこで本研究では，木材の曲げ強度性能を総合的に示す新たな指標の作成を試みた。曲げヤング率と曲げ強度に基づく主成分分析を行い，第一主成分得点を新たな指標とした。この指標を用いることで，木材試験体が有する曲げ強度性能について，文献値との比較を簡易に行うことが可能となった。

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