Andrew F. Voter

A pilot study of PSMA-targeted F-18-DCFPyL PET imaging of patients with adenoid cystic carcinoma

Colette J. Shen, Andrew F. Voter, Hyunseok Kang, Rajni Sharma et autres

Adenoid cystic carcinoma (ACC) is a rare malignancy of the salivary glands with poor long-term outcomes and with a need for improved imaging and therapeutic options. Prostate-specific membrane antigen (PSMA) expression has been observed in ACC and preliminary studies have demonstrated PET …

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806 A Novel Chromogenic Antibody Cocktail Including NKX3.1 and Basal Cell Markers for Automated Staining, Detection and Quantification of PSMA in Tissue Samples

Carolina Gomes-Alexandre, Tamara Lotan, Charles J. Bieberich, Andrew F. Voter et autres

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PSMA PET/CT–Derived Indicators and Outcomes After [ 177 Lu]Lu-PSMA-617: A Multicenter Retrospective Analysis from the U.S. Expanded-Access Program

Koichiro Kimura, Vishnu Murthy, Andrew F. Voter, Lilja B. Sólnes et autres

Pretherapeutic visual and quantitative indicators derived from prostate-specific membrane antigen (PSMA) PET/CT have been proposed as predictors of response to [177Lu]Lu-PSMA-617 (177Lu-PSMA) therapy in patients with metastatic castration-resistant prostate cancer. This study aimed to evaluate and compare the prognostic performance of these …

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Artificial intelligence-based lesion characterization and outcome prediction of prostate cancer on [18F]DCFPyL PSMA imaging

Linmei Zhao, Maliha R. Imami, Yuli Wang, Yitao Mao et autres

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DNA-damage dependent isoform switching modulates RIF1 DNA repair complex assembly and phase separation

Adenine Si-Hui Koo, Weiyan Jia, Sang Hwa Kim, Mark A. Scalf et autres

How RIF1 (RAP1 interacting factor 1) fulfills its diverse roles in DNA double-strand break repair, DNA replication, and nuclear organization remains elusive. Here, we show that alternative splicing of a cassette exon (Ex32) encoding a Ser/Lys-rich cassette in the RIF1 C-terminal domain …

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[ 68 Ga]Ga-PSMA-11 PET Tumor Volume Predicts Overall Survival of Patients with Metastatic Prostate Cancer Undergoing Taxane-Based Chemotherapy

Stephan Skawran, Andrei Gafita, Theo Lorenzini, Robert Tauber et autres

Prostate-specific membrane antigen (PSMA) PET has the potential to monitor the response to taxane-based chemotherapy in patients with prostate cancer and shows promise for predicting outcomes and improving response evaluation. This retrospective study aimed to determine the prognostic value of [68Ga]Ga-PSMA-11 PET …

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Race and Outcomes to [177Lu]Lu-PSMA-617 in Advanced Prostate Cancer

Avina Rami, Caiwei Zhong, Miguel Muniz, Wanling Xie et autres

Lu]Lu-PSMA-617 (LuPSMA) across racial groups. We evaluated the association between race and outcomes with LuPSMA in a multi-institutional cohort of consecutive patients with mCRPC treated with LuPSMA. The primary outcomes were PSA-50 rate, PSA-progression-free survival (PSA-PFS), and overall survival (OS). Statistical models …

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Assessment of PSMA PET/CT derived predictive markers for 177 Lu-PSMA-617 treatment outcomes: Results from the U.S. Expanded-Access program.

Koichiro Kimura, Vishnu Murthy, Andrew F. Voter, Abuzar Moradi Tuchayi et autres

5079 Background: 177 Lu-PSMA-617 (Lu-PSMA) contributes to prolong progression-free survival (PFS) and overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients who progressed after chemotherapy. Pretherapeutic prostate-specific membrane antigen (PSMA) PET/CT information can be used to predict Lu-PSMA therapy response patterns …

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A pilot study of PSMA-targeted F-18-DCFPyL PET imaging of patients with adenoid cystic carcinoma

Andrew F. Voter, Alireza Amindarolzarbi, Colette J. Shen, Jarey H. Wang et autres

Adenoid cystic carcinoma (ACC) is a rare malignancy of the salivary glands with poor long-term outcomes and with a need for improved imaging and therapeutic options. Prostate-specific membrane antigen (PSMA) expression has been observed in ACC and preliminary studies have demonstrated PET …

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Altering translation allows E. coli to overcome G-quadruplex stabilizers

Rachel R. Cueny, Andrew F. Voter, Aidan M. McKenzie, Marcel Morgenstern et autres

G-quadruplex (G4) structures can form in guanine-rich DNA or RNA and have been found to modulate cellular processes, including replication, transcription, and translation. Many studies on the cellular roles of G4s have focused on eukaryotic systems, with far fewer probing bacterial G4s. …

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Rethinking Radiology Research Residencies

Andrew F. Voter

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Prognostic value of quantitative PSMA-PET parameters during chemotherapy in prostate cancer.

Stephan Skawran, Andrei Gafita, Theo Lorenzini, Sebastian Hoberück et autres

33 Background: PSMA-PET/CT is increasingly being used to monitor chemotherapy in prostate cancer and shows promise for predicting outcomes and improving response evaluation. This retrospective study aimed to determine the prognostic value of quantitative tumor burden parameters derived from PSMA-PET/CT for overall …

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