Ming‐Hu Han

GABAB1R: A molecular bridge linking deep brain stimulation to antidepressant effects——A commentary on “NAcLat-DBS reduces GABAB1R expression of dopamine neurons to correct depressive symptoms in CMS mice"

Fang Li, Jing Sun, Ming‐Hu Han

Treatment-resistant depression (TRD) remains one of the most formidable challenges in clinical psychiatry. Despite the wide array of antidepressant medications, approximately one-third of patients with major depressive disorder (MDD) do not achieve a satisfactory response to these agents [1]. In this context, …

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Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience

Sherod E. Haynes, Anthony F. Lacagnina, Li Fang, Xiao Yang et autres

Background: Cumulative stress is a major risk factor for developing major depressive disorder (MDD), but not everyone experiencing chronic stress develops MDD. In those who do not, it is unclear at what point or by what mechanism a trajectory of stable resiliency …

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Neural Circuit Connections and Functions of Locus Coeruleus–Norepinephrine System

Hao Mei, Fang Li, Ming‐Hu Han

The locus coeruleus-norepinephrine (LC-NE) system is a phylogenetically conserved neuromodulatory hub that regulates fundamental brain states and behaviors, including arousal, cognition, emotion, and pain. This review integrates two critical perspectives to provide a unified framework for understanding this system. First, we synthesize …

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Anti-drift pose tracker (ADPT), a transformer-based network for robust animal pose estimation cross-species

Guoling Tang, Yaning Han, Xing Sun, Ming‐Hu Han et autres

Deep learning-based methods have advanced animal pose estimation, enhancing accuracy, and efficiency in quantifying animal behavior. However, these methods frequently experience tracking drift, where noise-induced jumps in body point estimates compromise reliability. Here, we present the anti-drift pose tracker (ADPT), a transformer-based …

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Author response: Anti-drift pose tracker (ADPT), a transformer-based network for robust animal pose estimation cross-species

Guoling Tang, Yaning Han, Xing Sun, Ruonan Zhang et autres

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Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype

Emily M. Teichman, Jianping Hu, Hsiao‐Yun Lin, Rachel Fisher-Foye et autres

Major Depressive Disorder (MDD) is a devastating, multifactorial disease with limited pharmacological treatment options. Patients with MDD exhibit alterations in their dopamine (DA) signaling pathways through the midbrain ventral tegmental area (VTA). A similar observation is also detected in preclinical models of …

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Effects of KCNQ potassium channel modulation on ventral tegmental area activity and connectivity in individuals with depression and anhedonia

Laurel Morris, Sara Costi, Sara Hameed, Katherine A. Collins et autres

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Author response: Anti-drift pose tracker (ADPT): A transformer-based network for robust animal pose estimation cross-species

Guoling Tang, Yaning Han, Xing Sun, Ruonan Zhang et autres

Deep learning-based methods have advanced animal pose estimation, enhancing accuracy and efficiency in quantifying animal behavior. However, these methods frequently experience tracking drift, where noise-induced jumps in body point estimates compromise reliability. Here, we present the Anti-Drift Pose Tracker (ADPT), a transformer-based …

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Anti-drift pose tracker (ADPT): A transformer-based network for robust animal pose estimation cross-species

Guoling Tang, Yaning Han, Xing Sun, Ruonan Zhang et autres

Abstract Deep learning-based methods have advanced animal pose estimation, enhancing accuracy and efficiency in quantifying animal behavior. However, these methods frequently experience tracking drift, where noise-induced jumps in body point estimates compromise reliability. Here, we present the Anti-Drift Pose Tracker (ADPT), a …

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The role of alcohol‐taking engram cells of the dorsomedial striatum in the mediation of excessive driving behaviors for alcohol

Yutong Liu, Carole Morel, Ming‐Hu Han

The authors have declared no conflict of interest. The data that support the findings of this study are openly available in PubMed with signed doi and reference numbers.

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Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice

Yi Han, Lin Ai, Lingzhen Song, Yu Zhou et autres

The potential brain mechanism underlying resilience to socially transferred allodynia remains unknown. Here, we utilize a well-established socially transferred allodynia paradigm to segregate male mice into pain-susceptible and pain-resilient subgroups. Brain screening results show that ventral tegmental area glutamatergic neurons are selectively …

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Anti-drift pose tracker (ADPT), a transformer-based network for robust animal pose estimation cross-species

Guoling Tang, Yaning Han, Xing Sun, Ruonan Zhang et autres

Deep learning-based methods have advanced animal pose estimation, enhancing accuracy, and efficiency in quantifying animal behavior. However, these methods frequently experience tracking drift, where noise-induced jumps in body point estimates compromise reliability. Here, we present the anti-drift pose tracker (ADPT), a transformer-based …

cn (code pays fourni par la source)