Amber Valeri

Phase I Clinical Study of DOC1021 (dubodencel) for Adjuvant Immunotherapy of Glioblastoma

Joseph Georges, Christina M. Clay, Sabina Amin, Ashley M. Goralczyk et autres

Abstract PURPOSE Newly-diagnosed glioblastoma (nGBM) is a devastating tumor with median survival of only 14-18 months despite aggressive standard of care (SOC). Dendritic cell (DC) homologous antigenic double-loading provides a powerful pattern-based signal that initiates cDC1-like skewing of monocytic precursors, inducing downstream …

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A Single-Center Review of Renal Replacement Therapy in Patients With Acute Traumatic Brain Injury

Gena V Topper, Michael Bamimore, T Hess, Jacob Metheny et autres

BACKGROUND: Traumatic brain injury (TBI) is a major cause of morbidity, and concomitant acute kidney injury presents substantial management challenges. Continuous renal replacement therapy (CRRT) is thought to cause less hemodynamic instability than intermittent hemodialysis (IHD) after TBI, but factors associated with …

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A Single-Center Review of Renal Replacement Therapy in Acute Traumatic Brain Injury

Gena V Topper, Michael Bamimore, Jacob Metheny, Patrick G. Morris et autres

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Intramedullary spinal cord abscess as postoperative complication: A case report

Amber Valeri, Adam Alayli, Jonah Gordon, Gavin Lockard et autres

Background: Intramedullary spinal cord abscesses (ISCA) can result in high morbidity and mortality if not treated in a timely manner. The incidence and outcomes of postsurgical ISCA are unknown. We present a case of a 52-year-old male patient with neurofibromatosis type 1 …

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Exosome-mediated brain tumor diagnostics from peripheral fluids: a review of clinical data.

Meghna Bhattacharyya, Justin Gold, Ryan Moncman, Clint Badger et autres

Definitive diagnoses in neuro-oncology often require invasive procedures, such as surgical biopsies to obtain tissue for histopathologic and molecular interrogation. Patients with small lesions that may respond to nonsurgical treatments, such as chemoradiation, may nevertheless undergo surgery with potential risks to obtain …

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SURG-26. HYDROCEPHALUS IN LEPTOMENINGEAL DISEASE: TANDEM OMMAYA RESERVOIR-SHUNT FOR INTRATHECAL CHEMOTHERAPY ADMINISTRATION

Amber Valeri, Arnold B. Etame, André Beer‐Furlan, James Liu et autres

Abstract INTRODUCTION Leptomeningeal disease (LMD) is a rare late-stage manifestation of disease progression in solid and hematologic malignancies. Although advances in intrathecal therapeutic (IT) provide treatment options beyond the traditional WBRT, these IT treatment strategies are limited when LMD patients develop associated …

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Acute neurological injury in pediatric patients with single-ventricle congenital heart disease

Shih‐Shan Lang, Amber Valeri, Phillip B. Storm, Gregory G. Heuer et autres

OBJECTIVE: Single-ventricle congenital heart disease (CHD) in pediatric patients with Glenn and Fontan physiology represents a unique physiology requiring the surgical diversion of the systemic venous return from the superior vena cava (Glenn) and then the inferior vena cava (Fontan) directly to …

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Provision of rapid and specific ex vivo diagnosis of central nervous system lymphoma from rodent xenograft biopsies by a fluorescent aptamer

Joseph Georges, Xiaodong Qi, Xiaowei Liu, Yu Zhou et autres

OBJECTIVE: Differentiating central nervous system (CNS) lymphoma from other intracranial malignancies remains a clinical challenge in surgical neuro-oncology. Advances in clinical fluorescence imaging contrast agents and devices may mitigate this challenge. Aptamers are a class of nanomolecules engineered to bind cellular targets …

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Head of bed elevation in pediatric patients with severe traumatic brain injury

Shih‐Shan Lang, Amber Valeri, Bingqing Zhang, Phillip B. Storm et autres

OBJECTIVE: Head of bed (HOB) elevation to 30° after severe traumatic brain injury (TBI) has become standard positioning across all age groups. This maneuver is thought to minimize the risk of elevated ICP in the hopes of decreasing cerebral blood and fluid …

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Delta-Aminolevulinic Acid-Mediated Photodiagnoses in Surgical Oncology: A Historical Review of Clinical Trials

Joseph Georges, Amber Valeri, Huan Wang, Aaron Brooking et autres

Fluorescence imaging is an emerging clinical technique for real-time intraoperative visualization of tumors and their boundaries. Though multiple fluorescent contrast agents are available in the basic sciences, few fluorescence agents are available for clinical use. Of the clinical fluorophores, delta aminolevulinic acid …

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Real-Time Visualization of Human Malignant Brain Tumor Cells with Delta-Aminolevulinic Acid (5ALA)

Adam Dalkilic, Amber Valeri, Aaron Brooking, Joseph Georges et autres

Poster and abstract under embargo until 5/8/2020.

Pediatric diffuse intrinsic anaplastic astrocytoma of the medulla oblongata

Amir Kershenovich, Amber Valeri

Focal tumors of the brain stem are classically low grade astrocytomas. We present the rare case of a child with an anaplastic astrocytoma confined to the medulla oblongata. An 11-year-old male found to have an intrinsic tumor of the medulla oblongata; the …

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