Ilia E. Ichetovkin

Corrigendum to “Analytical validation of protein biomarkers for risk of spontaneous preterm birth” [Clin. Mass Spectrom. 3 (2017) 25–38]

Chad L. Bradford, Rob Severinsen, Trina Pugmire, Matison Rasmussen et autres

[This corrects the article DOI: 10.1016/j.clinms.2017.06.002.].

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Variants in obesity-related genes in a population with early-onset obesity

Patrick W. Kleyn, Ilia E. Ichetovkin, Ida H Moeller

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

eP126: Frequency of MC4R pathway variants in a large US cohort of pediatric and adult patients with severe obesity

Eric G. Bend, Tiago Antão, Ilia E. Ichetovkin, Rick Norton et autres

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eP125: Variants in obesity-related genes in a population with early-onset obesity

Patrick Kleyn, Ilia E. Ichetovkin, Ida Hatoum Moeller

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Use of a Comprehensive 66‐Gene Cholestasis Sequencing Panel in 2171 Cholestatic Infants, Children, and Young Adults

Saul J. Karpen, Binita Maya Kamath, John J. Alexander, Ilia E. Ichetovkin et autres

OBJECTIVES: Cholestasis is caused by a wide variety of etiologies, often genetic in origin. Broad overlap in clinical presentations, particularly in newborns, renders prioritizing diagnostic investigations challenging. In this setting, a timely, comprehensive assessment using a multigene panel by a clinical diagnostic …

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Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation

Shubh D. Sharma, Alastair S. Garfield, Bhavik P. Shah, Patrick W. Kleyn et autres

In this work we summarize our understanding of melanocortin 4 receptor (MC4R) pathway activation, aiming to define a safe and effective therapeutic targeting strategy for the MC4R. Delineation of cellular MC4R pathways has provided evidence for distinct MC4R signaling events characterized by …

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Analytical validation of protein biomarkers for risk of spontaneous preterm birth

Chad L. Bradford, Rob Severinsen, Trina Pugmire, Matison Rasmussen et autres

Presented are the validation results of a second-generation assay for determining the relative abundances of two protein biomarkers found in maternal serum that predict an individual's risk of spontaneous preterm birth. The sample preparation workflow is complex, consisting of immuno-depletion of high-abundance …

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Development and validation of a spontaneous preterm delivery predictor in asymptomatic women

George Robert Saade, Kim Boggess, SCOTT A. SULLIVAN, Glenn R. Markenson et autres

BACKGROUND: Preterm delivery remains the leading cause of perinatal mortality. Risk factors and biomarkers have traditionally failed to identify the majority of preterm deliveries. OBJECTIVE: To develop and validate a mass spectrometry-based serum test to predict spontaneous preterm delivery in asymptomatic pregnant …

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17: Clinical validation of a two-protein test for spontaneous preterm birth (sPTB) prediction in a large multicenter prospective study of asymptomatic women

George Robert Saade, Kim Boggess, SCOTT A. SULLIVAN, Glenn R. Markenson et autres

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253: Mechanistic insights from serum proteomic biomarkers predictive of spontaneous preterm birth

Jeff Flick, George Robert Saade, Kim Boggess, SCOTT A. SULLIVAN et autres

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193: Verification of a proteomic serum-based classifier to predict spontaneous preterm birth in asymptomatic patients

Kim Boggess, George Robert Saade, SCOTT A. SULLIVAN, Glenn R. Markenson et autres

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Development and Validation of a Multi-Analyte Biomarker Assay to Determine Preterm Birth Risk

Chad L. Bradford, Robert D. Severinsen, Trina Pugmire, Tracey C. Fleischer et autres

Introduction: Preterm birth (PTB), a condition with complex etiological factors, is the leading cause of neonatal mortality and morbidity. Existing tests have poor performance, especially for nulliparous women. There is a compelling need to identify robust biomarkers of PTB to enable identification …

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