Trina Pugmire

A-343 Using a ratio-metric approach to evaluate home-collected blood samples: a proof-of-concept study applied to predicting time to birth in term pregnancies

Andrew Gassman, Mai Corpuz, Trina Pugmire, MAX T. W. DUFFORD et autres

Abstract Background Accurately predicting delivery timing remains an unmet need in obstetrics. Only 5% of women deliver on their estimated delivery date, and 30% deliver more than 10 days outside this estimate. Although early ultrasound improves estimation accuracy, it is not universally …

Corrigendum to “Analytical validation of protein biomarkers for risk of spontaneous preterm birth” [Clin. Mass Spectrom. 3 (2017) 25–38]

Chad L. Bradford, Rob Severinsen, Trina Pugmire, Matison Rasmussen et autres

[This corrects the article DOI: 10.1016/j.clinms.2017.06.002.].

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Analytical validation of protein biomarkers for risk of spontaneous preterm birth

Chad L. Bradford, Rob Severinsen, Trina Pugmire, Matison Rasmussen et autres

Presented are the validation results of a second-generation assay for determining the relative abundances of two protein biomarkers found in maternal serum that predict an individual's risk of spontaneous preterm birth. The sample preparation workflow is complex, consisting of immuno-depletion of high-abundance …

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Development and validation of a spontaneous preterm delivery predictor in asymptomatic women

George Robert Saade, Kim Boggess, SCOTT A. SULLIVAN, Glenn R. Markenson et autres

BACKGROUND: Preterm delivery remains the leading cause of perinatal mortality. Risk factors and biomarkers have traditionally failed to identify the majority of preterm deliveries. OBJECTIVE: To develop and validate a mass spectrometry-based serum test to predict spontaneous preterm delivery in asymptomatic pregnant …

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253: Mechanistic insights from serum proteomic biomarkers predictive of spontaneous preterm birth

Jeff Flick, George Robert Saade, Kim Boggess, SCOTT A. SULLIVAN et autres

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Development and Validation of a Multi-Analyte Biomarker Assay to Determine Preterm Birth Risk

Chad L. Bradford, Rob Severinsen, Trina Pugmire, Tracey C. Fleischer et autres

Introduction: Preterm birth (PTB), a condition with complex etiological factors, is the leading cause of neonatal mortality and morbidity. Existing tests have poor performance, especially for nulliparous women. There is a compelling need to identify robust biomarkers of PTB to enable identification …

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