Joonatan Palmu

Lactic acid bacteria and endogenous ethanol mediate proton pump inhibitor-associated MASLD: a multicohort cross-sectional mediation analysis

Mark Davids, Hilde Herrema, Albert K Groen, Henrike Galenkamp et autres

Background & aims Proton pump inhibitor (PPI) use has been associated with metabolic dysfunction associated with steatotic liver disease (MASLD) in multiple studies. While the association is confounded by various risk factors, such as BMI and age, a potential mediating factor of …

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LEVERAGING A GENETIC PROXY TO INVESTIGATE THE EFFECTS OF LIFELONG ADRENERGIC RECEPTOR BLOCKADE

Li-Fang Yeo, Joonatan Palmu, Janne Isojärvi, Tapio Hellman et autres

Objective: The sympathetic nervous system plays a key role in blood pressure regulation and hypertension pathophysiology. We investigated a genetic variant that we found to act like a natural lifelong adrenergic receptor blockade. Design and method: DBH encodes the enzyme dopamine beta-hydroxylase, …

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Associations between gut microbiome and circulating cytokines: a cross-sectional analysis in the FINRISK 2002 population cohort

Hassan Mahmoud Diab, Ville L. Langén, Li-Fang Yeo, Veikko V Salomaa et autres

BACKGROUND: A growing body of evidence suggests a relationship between gut microbiome and circulating cytokines, yet there is still a lack of large-scale population-based studies investigating gut microbiome-cytokine associations. In this cross-sectional study, we aimed at investigating the associations of gut microbiome …

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Associations between gut microbiome and circulating cytokines: a cross-sectional analysis in the FINRISK 2002 population cohort

Hassan Mahmoud Diab, Ville L. Langén, Li-Fang Yeo, V. Salomaa et autres

Background A growing body of evidence suggests a relationship between gut microbiome and circulatingcytokines, yet there is still a lack of large-scale population-based studies investigating gut microbiome-cytokineassociations. In this cross-sectional study, we aimed at investigating the associations of gut microbiome (exposurevariable) with …

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Associations between gut microbiome and circulating cytokines: a cross-sectional analysis in the FINRISK 2002 population cohort

Hassan Mahmoud Diab, Ville L. Langén, Li-Fang Yeo, V. Salomaa et autres

Background A growing body of evidence suggests a relationship between gut microbiome and circulatingcytokines, yet there is still a lack of large-scale population-based studies investigating gut microbiome-cytokineassociations. In this cross-sectional study, we aimed at investigating the associations of gut microbiome (exposurevariable) with …

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Gut Microbiome as a Risk Factor for Future CKD

Tapio Hellman, Li-Fang Yeo, Joonatan Palmu, Aki Samuli Havulinna et autres

Introduction Gut microbiome has been linked with chronic kidney disease (CKD) in several small cross-sectional studies. However, the relationship between baseline gut microbiome and long-term incident CKD remains unknown. Methods We performed fecal sampling and measured serum creatinine (SCR) ( N = …

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Gut Microbiome as a Risk Factor for Future CKD

Tapio Hellman, Li-Fang Yeo, Joonatan Palmu, Aki Samuli Havulinna et autres

Introduction: Gut microbiome has been linked with chronic kidney disease (CKD) in several small crosssectionalstudies. However, the relationship between baseline gut microbiome and long-term incidentCKD remains unknown.Methods: We performed fecal sampling and measured serum creatinine (SCR) (N ¼ 6699) and urinealbumin-to-creatinine ratio …

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Gut Microbiome as a Risk Factor for Future CKD

Tapio Hellman, Li-Fang Yeo, Joonatan Palmu, Aki Samuli Havulinna et autres

Introduction: Gut microbiome has been linked with chronic kidney disease (CKD) in several small crosssectionalstudies. However, the relationship between baseline gut microbiome and long-term incidentCKD remains unknown.Methods: We performed fecal sampling and measured serum creatinine (SCR) (N ¼ 6699) and urinealbumin-to-creatinine ratio …

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Gut Microbiota and Parkinson’s disease - a prospective analysis of the FINRISK 2002 Study

Katri Sääksjärvi, Juho Tynkkynen, Veikko V Salomaa, Aki Samuli Havulinna et autres

Abstract Background Parkinson’s disease (PD) is a neurodegenerative movement disorder with mainly unknown etiology. Constipation is a common symptom, and changes in gut microbiota may play role in PD pathogenesis. Previous studies exploring microbial associations to PD have been mostly cross-sectional, and …

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P139 THE GUT MICROBIOME AS A PREDICTOR OF INCIDENT HYPERTENSION: DATA FROM A POPULATION SAMPLE OF 3055 INDIVIDUALS WITH A FOLLOW-UP OF 20 YEARS

Teemu Niiranen, Joonatan Palmu, Aki Samuli Havulinna, Pekka Jousilahti et autres

Background and Objective: Our goal was to examine the previously unknown long-term association between gut microbiome composition and incident hypertension in a representative population cohort. Methods: We collected fecal samples from a population sample of 3,055 non-hypertensive Finns (mean age 43.1 years; …

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Genetics, transcriptomics, metagenomics, and metabolomics in the pathogenesis and prediction of atrial fibrillation

Suvi Linna-Kuosmanen, Matti A. Vuori, Tuomas Kiviniemi, Joonatan Palmu et autres

The primary cellular substrates of atrial fibrillation (AF) and the mechanisms underlying AF onset remain poorly characterized and therefore, its risk assessment lacks precision. While the use of omics may enable discovery of novel AF risk factors and narrow down the cellular …

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Verenpainetaudin lääkehoito yksilöllistyy

Felix Vaura, Joonatan Palmu, Karri Suvila, Annika Lindroos et autres

• Verenpaineen tavoitetaso määräytyy Finriski-pisteiden ja perussairauksien mukaan. • Verenpainetaudin lääkehoito kannattaa yleensä aloittaa angiotensiinireseptorin salpaajalla tai angiotensiinikonvertaasin estäjällä. • Toisen ja kolmannen lääkkeen valintaan vaikuttaa erityisesti, onko potilaalla diabetes, krooninen munuaistauti tai sydän- ja verisuonisairaus. • Spironolaktoni lienee tehokkain lääke hoitoresistenttiin …