Gut Microbiome as a Risk Factor for Future CKD
Rattachement africain : fi, my, us, in. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction: Gut microbiome has been linked with chronic kidney disease (CKD) in several small crosssectionalstudies. However, the relationship between baseline gut microbiome and long-term incidentCKD remains unknown.Methods: We performed fecal sampling and measured serum creatinine (SCR) (N ¼ 6699) and urinealbumin-to-creatinine ratio (UACR) (N ¼ 797) in a population-based cohort examined in the year 2002. Weassessed the multivariable-adjusted associations of gut metagenome with baseline SCR, baseline UACR,and register-based incident CKD.Results: The mean age of the participants was 49.5 12.9 years and 45.8% were men. During a medianfollow-up of 18.6 years, 108 participants developed incident CKD. In prospective analyses, increasedbaseline gut microbiome alpha diversity was associated with lower risk of incident CKD (hazard ratio per 1SD: 0.84; 95% confidence interval [CI]: 0.71–0.99; P ¼ 0.04). Gut microbial beta diversity and taxa were notrelated to incident CKD (P $ 0.09 for all). In cross-sectional analyses, alpha diversity (beta per 1 SD: 1.28;95% CI: 0.64–1.98; P < 0.001) and beta diversity (P ¼ 0.002; R2 ¼ 0.12%) were associated with SCR, whereasno associations were observed for UACR. In total, 43 significant species-level associations with SCR wereobserved and 16 negative associations (37.2%) for species belonging to the Lachnospiraceae family.Conclusion: Our results suggest that decreased gut microbial diversity may be related to risk of future CKDand that a potential link between the Lachnospiraceae family and desirable kidney health exists. Our resultsextend previous cross-sectional studies and help to establish the basis for examining gut microbiomeas a CKD risk factor.
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Le contrôle bibliographique ouvert
Où se fait cette recherche
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Turku University Hospital pays non établi dans la noticeÉtablissement de santé
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University of Turku pays non établi dans la noticeUniversité ou école supérieure
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Cancer Research Malaysia pays non établi dans la noticeOrganisation à but non lucratif
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University of Helsinki pays non établi dans la noticeUniversité ou école supérieure
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Finnish Institute for Health and Welfare pays non établi dans la noticeOrganisme public
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Institute for Molecular Medicine Finland pays non établi dans la noticeStructure de recherche
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Lappeenranta-Lahti University of Technology pays non établi dans la noticeUniversité ou école supérieure
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University of California San Diego pays non établi dans la noticeUniversité ou école supérieure
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National Institute of Health and Family Welfare pays non établi dans la noticeOrganisme public
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National Institute for Health and Welfare pays non établi dans la noticeStructure de recherche
Turku University Hospital, University of Turku et Cancer Research Malaysia, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.