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2025
article
OpenAlex
Malte B. Kuehl, Yusuke Okabayashi, Milagros N. Wong, Lukas Gernhold et autres
, the integration of biological layers (that is, cell structure, subcellular domains and signalling activity) remains challenging. This is due to limitations in the compositions of antibody panels and image resolution, which together restrict the scope of image analysis. Here we present …
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2025
article
OpenAlex
Sebastian Marcel Wingen-Heimann, Asad Ullah, Marta Rebeca Cruz Aguilar, Stefanie K. Gräfe et autres
BACKGROUND: Clostridioides difficile infections (CDIs) remain a prevalent and costly healthcare challenge, particularly affecting elderly, comorbid patients. Evidence on the health economic burden of CDI in Germany, particularly in refractory and recurrent patients is limited. METHODS: The IBIS study was a non-interventional …
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2024
article
OpenAlex
Jon Salmanton‐García, Francesco Marchesi, Milan Navrátil, Klára Piukovics et autres
Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM …
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2024
article
OpenAlex
Katharina Giesbrecht, Rebeca Cruz Aguilar, Stefanie K. Gräfe, Klaus‐Peter Hunfeld et autres
OBJECTIVES: The objective of this study is to examine the comparative effectiveness of vancomycin and metronidazole in a confirmatory analysis of event-free survival (EFS) after initial infection in patients with Clostridioides difficile from a German multicentre cohort study. METHODS: The IBIS multicentre …
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2024
erratum
OpenAlex
Tobias Lahmer, Jon Salmanton‐García, Francesco Marchesi, Shaimaa El‐Ashwah et autres
Acknowledgements Members of the EPICOVIDEHA registry.
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2024
article
OpenAlex
Imke Liebold, Amirah Al Jawazneh, Christian Casar, Clarissa Lanzloth et autres
Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic cells are defined by homogeneous characteristics, ignoring their original cell lineage identity. We found that in an interleukin-4 (IL-4)-enriched environment, the sensing of apoptotic neutrophils by macrophages triggered their tissue remodeling …
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2024
article
OpenAlex
Jon Salmanton‐García, Francesco Marchesi, Francesca Farina, Barbora Weinbergerová et autres
Background: The COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading to more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, and monoclonal antibodies have been effective for the general population, their benefits …
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2024
article
OpenAlex
Tobias Lahmer, Jon Salmanton‐García, Francesco Marchesi, Shaimaa El‐Ashwah et autres
The risk for a severe coronavirus disease 2019 (COVID-19) with need for an intensive care unit (ICU) admission in a non-immunocompromised vaccinated population dropped from 5% at the beginning of the pandemic to at least 0.2% and is still decreasing since the …
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2023
article
OpenAlex
Shaimaa El‐Ashwah, Jon Salmanton‐García, Federico Itri, Pavel P. Zak et autres
Since the beginning of the COVID-19 pandemic, there has been an overall improvement in patient mortality. However, haematological malignancy patients continue to experience significant impacts from COVID-19, including high rates of hospitalization, intensive care unit (ICU) admissions, and mortality. In comparison to …
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2023
article
OpenAlex
Giuseppe Rossi, Jon Salmanton‐García, Chiara M. Cattaneo, Francesco Marchesi et autres
OBJECTIVES: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. METHODS: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies …
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2023
article
OpenAlex
Jon Salmanton‐García, Francesco Marchesi, Philipp A. Koehler, Barbora Weinbergerová et autres
INTRODUCTION: Molnupiravir and nirmatrelvir/ritonavir are antivirals used to prevent progression to severe SARS-CoV-2 infections and decrease hospitalisation and mortality rates. Nirmatrelvir/ritonavir was authorised in Europe in December 2021, whereas molnupiravir is not yet licensed in Europe as of February 2022. Molnupiravir may …
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2023
article
OpenAlex
Jon Salmanton‐García, Francesco Marchesi, Andreas Birkedal Glenthøj, Yavuz Memis Bilgin et autres
Topic: 30. Infections in hematology (incl. supportive care/therapy) Background: There is a lack of consolidated data has resulted in a general skepticism on anti-SARS-CoV-2 fourth dose efficacy. As a consequence, only few individuals received a fourth dose, despite several data supports the …
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