Yuri Bozzi

Microglia, cerebellar inflammation, and autism spectrum disorders: Developmental mechanisms and therapeutic perspectives

Martina Schiano-Visconte, Luigi Balasco, Simona Casarosa, Yuri Bozzi

Autism spectrum disorders (ASD) are neurodevelopmental conditions characterized by deficits in social interaction and communication, as well as restricted and repetitive behaviors. These conditions often co-occur with medical issues linked to synaptic alterations, which compromise synaptic integrity and are associated with brain …

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Autism subtypes identified using cross-species functional connectivity analyses

Marco Pagani, Valerio Zerbi, Silvia Gini, Filomena Grazia Alvino et autres

It is often assumed that phenotypic heterogeneity in autism reflects underlying pathobiological variation. However, direct evidence supporting this link is lacking. Leveraging cross-species functional neuroimaging, we show that brain dysconnectivity patterns in autism can be parsed into biologically dissociable subtypes. Specifically, we …

Autism subtypes identified using cross-species functional connectivity analyses

Marco Pagani, Valerio Zerbi, Silvia Gini, Filomena Grazia Alvino et autres

It is often assumed that phenotypic heterogeneity in autism reflects underlying pathobiological variation. However, direct evidence supporting this link is lacking. Leveraging cross-species functional neuroimaging, we show that brain dysconnectivity patterns in autism can be parsed into biologically dissociable subtypes. Specifically, we …

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Ten questions concerning dynamic sensory variation in salutogenic building design

Rossano Albatici, Yuri Bozzi, Massimo Pizzato, Simone Torresin et autres

• Salutogenic building design is discussed based on Antonovsky’s Model • The article brings together experts in architecture, IEQ, neuroscience and immunology • Sensory variability is viewed as a way to train the body and sustain immune balance • Mechanisms linking sensory …

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Astaxanthin improves behavioural and immune dysfunction in the Shank3b mouse model of autism spectrum disorder

Anjana Madhavan, Martina Schiano-Visconte, Lauren Dutton, Mattia Cantalupo et autres

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and interaction, and repetitive behaviours. Numerous studies have associated ASD with immune dysregulation and inflammation, with neuroinflammatory processes reported in ASD individuals and mouse models. Altered immune cell …

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Ct values of inflammatory and oxidative stress genes in Shank3b-/- and Shank3b+/+ mice treated with astaxanthin

Anjana Madhavan, Martina Schiano-Visconte, Lauren Dutton, Mattia Cantalupo et autres

This dataset contains RT-qPCR Ct values obtained from cerebellum, bone marrow, and spleen samples of Shank3b+/+ and Shank3b-/- mice orally treated with 50 mg/kg astaxanthin (five times per week for four consecutive weeks). For each experimental condition, Ct values from three independent …

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Early-life adversity shapes anomalous spontaneous behavior in mice heterozygous for Cntnap2

Gabriele Chelini, Viviana Canicatti, Vanes Cibin, Nicoletta Berardi et autres

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A role for the TMEM132D gene in psychiatric disorders revealed by a neuroscience class assignment

Reem Hjoj, Yuri Bozzi

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Developmental excitation-inhibition imbalance permanently reprograms autism-relevant social brain circuits

Alexia Stuefer, Giulia Colombo, Silvia Gini, David Sastre-Yagüe et autres

Abstract An influential theory proposes that an imbalance between excitation and inhibition (E:I) plays a central role in the etiology of autism and related developmental disorders. However, controversy exists as to whether this imbalance is a direct causal mechanism for autism, or …

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Early-life adversities compromise behavioral development in male and female mice heterozygous for CNTNAP2

Gabriele Chelini, Tommaso Fortunato-Asquini, Enrica Cerilli, Katia Monsorno et autres

The etiological complexity of psychiatric disorders arises from the dynamic interplay between genetic and environmental vulnerabilities. Among the environmental components, early-life adversities are a major risk factor for developing a psychiatric condition. Yet, the interaction between adversities early in life and genetic …

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Unraveling white matter alterations in autism: the role of oligodendrocytes, microglia, and neuroinflammation

Yuri Bozzi

Researchers are increasingly investigating the developmental origins of white matter alterations in autism spectrum disorder (ASD). A recent review by Canada, Evans, and Pelphrey highlights the roles of oligodendrocytes and microglia in ASD-related white matter abnormalities. Evidence suggests that ASD risk genes …

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Biological subtyping of autism via cross-species fMRI

Marco Pagani, Valerio Zerbi, Silvia Gini, Filomena Grazia Alvino et autres

It is frequently assumed that the phenotypic heterogeneity in autism spectrum disorder reflects underlying pathobiological variation. However, direct evidence in support of this hypothesis is lacking. Here, we leverage cross-species functional neuroimaging to examine whether variability in brain functional connectivity reflects distinct …

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