Nicolás I. Torres

Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells

Ada Gabriela Blidner, Camila Agustina Bach, Pablo Andrés García, Joaquin Pedro Merlo et autres

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Do galectins serve as soluble ligands for immune checkpoint receptors?

Nicolás I. Torres, Federico Gastón Baudou, Marco A Scheidegger, Tomás Dalotto‐Moreno et autres

Abstract

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A single-step, rapid, and versatile method for simultaneous detection of cell surface glycan profiles using fluorochrome-conjugated lectins

Nicolás I. Torres, Montana N Manselle Cocco, Ramiro M. Perrotta, Yamil Damian Mahmoud et autres

Cell surface glycans play essential roles in diverse physiological and pathological processes and their assessment has important implications in biomedicine and biotechnology. Here we present a rapid, versatile, and single-step multicolor flow cytometry method for evaluation of cell surface glycan signatures using …

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Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs

Nicolás A. Pinto, Martı́n C. Abba, Lorena Laporte, Juan M. Pérez Sáez et autres

Abstract Non-melanoma skin cancer (NMSC) has risen dramatically as a result of chronic exposure to sunlight ultraviolet (UV) radiation, climatic changes and clinical conditions associated with immunosuppression. In spite of considerable progress, our understanding of the mechanisms that control NMSC development and …

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High-throughput screening method for discovering CatSper inhibitors using membrane depolarization caused by external calcium chelation and fluorescent cell barcoding

Guillermina María Luque, Liza J. Schiavi‐Ehrenhaus, Martina Jabloñski, Paula A. Balestrini et autres

The exclusive expression of CatSper in sperm and its critical role in sperm function makes this channel an attractive target for contraception. The strategy of blocking CatSper as a male, non-hormonal contraceptive has not been fully explored due to the lack of …

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Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma

Guillermo A. Videla-Richardson, Olivia Morris-Hanon, Nicolás I. Torres, Mariana Belén Vera et autres

Despite recent advances in diagnosis and treatment, glioblastoma (GBM) represents the most common and aggressive brain tumor in the adult population, urging identification of new rational therapeutic targets. Galectins, a family of glycan-binding proteins, are highly expressed in the tumor microenvironment (TME) …

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Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8+ T Cell Proliferation

Jessica Mariel Sierra, Florencia Secchiari, Sol Yanel Núñez, Ximena L. Raffo Iraolagoitia et autres

Natural Killer (NK) cells play a key role in cancer immunosurveillance. However, NK cells from cancer patients display an altered phenotype and impaired effector functions. In addition, evidence of a regulatory role for NK cells is emerging in diverse models of viral …

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Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1

Andrea Ziblat, Ximena L. Raffo Iraolagoitia, Sol Yanel Núñez, Nicolás I. Torres et autres

Although natural killer (NK) cells infiltrate clear cell renal cell carcinomas (ccRCC), the most frequent malignancy of the kidney, tumor progression suggests that they become dysfunctional. As ccRCC-driven subversion of NK cell effector functions is usually accompanied by phenotypic changes, analysis of …

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[A functional platform to monitor SARS-CoV-2-specific T cell responses in vaccinated individuals and COVID-19 recovered patients].

Montana N Manselle Cocco, Florencia Veigas, Camila Agustina Bach, Ada Gabriela Blidner et autres

The rapid spread of the SARS-CoV-2, the causative agent of the emergent pandemic disease COVID-19, requires the urgent commitment of the immunology community to understand the adaptive immune response developed by COVID-19 convalescent patients and individuals vaccinated with different strategies and schemes, …

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Experiencia de educación sobre la crianza en un asentamiento de Colombia.

Liliana Villa Vélez, Jaider Camilo Otálvaro-Orrego, Fernando Peñaranda Correa, Miryam Bastidas-Acevedo et autres

Abstract (analytical)This paper presents the experience of a child rearing educational process. This work aimed to promote transformations in people and their living conditions and is based on Action Research for child rearing. For two years, 40 Thematic Research circles were held …

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Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein

Nicolás I. Torres, María Victoria Regge, Florencia Secchiari, Adrián David Friedrich et autres

Background Natural killer and cytotoxic CD8+ T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor elimination through recognition of the MHC class I chain-related proteins A and B (MICA and MICB). Both molecules are …

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Restitución de la inmunidad antitumoral a partir de la generación de anticuerpos contra MICA

Nicolás I. Torres

Vencer el escape inmune del tumor y erradicar los tumores y metástasis constituye un desafío en inmuno-oncología. Las células T CD8+ citotóxicas y las citotóxicas naturales (células NK) son jugadores importantes en la inmunidad tumoral. Ambas poblaciones expresan NKG2D, un receptor activador …