Florencia Veigas

PP01.58: Impact of Molecular Profiling on Clinical Management of LATAM Cancer Patients: Insights from a Next Generation Sequencing and Immunohistochemistry Panel

Andrea Mendoza Bertelli, Delfina Dibarbora, María Florencia Cantarella, María Romina Girotti et autres

ar, pe, co (code pays fourni par la source)

Intrinsic metabolic and immune impairments in a genetic mouse model of schizophrenia

Martina Belmonte, Sofia Lopez Cardoso, Anabella Ayelen Di Pietro, Florencia Veigas et autres

Schizophrenia is a disorder of still unknown aetiology characterized by positive, negative and cognitive symptoms. The first evident signs emerge at the end of adolescence and the beginning of adulthood as a psychotic episode. Patients are then treated with antipsychotics to ameliorate …

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Cross-resistance mechanisms between targeted therapies and immunotherapies in melanoma

Florencia Veigas

El melanoma cutáneo es el tipo de cáncer de piel con mayor tasa de mortalidad y capacidad metastásica. A pesar de los avances en terapias dirigidas (TD) e inmunoterapias basadas en inhibidores de puntos de control inmunológicos (ICI), la sobrevida a 5 …

Clinical efficacy of a next-generation sequencing (NGS) and immunohistochemistry (IHC) panel in patients with advanced cancer in Argentina.

Florencia Cantarella, Andrea Mendoza Bertelli, Romina Girotti, Anaclara Marino et autres

e15154 Background: The analysis of somatic genomic alterations, evaluation of DNA mismatch repair (MMR) proteins, and examination of PD-L1 expression in tumor biopsies are crucial for prognosis and informed therapeutic decisions. However, their clinical implementation in Argentina faces challenges due to economic …

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217 Exploring glycosylation-dependent circuits for prediction of antitumor immune response and immunotherapy outcomes in melanoma and colorectal cancer

Joaquin Pedro Merlo, Yamil Damian Mahmoud, Florencia Veigas, Marco A Scheidegger et autres

Background Although immunotherapies have emerged as efficient strategies for treating cancer, biomarkers for outcome prediction are still under debate. Relevant biomarkers such as PD-L1, tumor mutational burden, and microsatellite instability (MSI) have shown limited efficacy as stand-alone markers.1 2 Moreover, aberrant glycosylation …

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Abstract 2261: Deciphering cross-resistance mechanisms associated to targeted therapies and immunotherapy in BRAFmutmelanoma: The role of tumor-associated macrophages and galectin-1

Florencia Veigas, Yamil Damian Mahmoud, Joaquin Pedro Merlo, Montana Manselle Cocco et autres

Abstract Both targeted therapies (TT) and immunotherapies have revolutionized the treatment of metastatic melanoma patients. Particularly, TT with BRAFi or BRAFi/MEKi leads to prompt but not durable responses in most patients due to the development of resistance within 1 year. Tumors refractory …

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Abstract 6548: Bioinformatic characterization of dendritic and T cell subpopulations in the tumor microenvironment across different cancer types by single-cell RNA-Seq analysis

Yamil Damian Mahmoud, Natalia Rego, Marcela Vilariño, Florencia Veigas et autres

Abstract Although the development of single-cell RNAseq (scRNAseq) has improved the knowledge of the tumor microenvironment (TME), there is not a clear understanding of specific cell subtypes, markers that define these cell populations, nor the interaction between them. Previously, we showed that …

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Abstract 1265: Pan-cancer study of glycosylation-related gene expression: The emerging role of galectin-2 in tumor progression

Montana N Manselle Cocco, Florencia Veigas, Yamil Damian Mahmoud, Mora Massaro et autres

Abstract Aberrant glycosylation has emerged as an important hallmark of cancer playing a critical role in the modulation of tumor cell aggressiveness, invasiveness, and modulation of the immune and vascular programs. However, the cellular and molecular mechanisms implicated in glycan-driven cancer progression …

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Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs

Nicolás A. Pinto, Martı́n C. Abba, Lorena Laporte, Juan M. Pérez Sáez et autres

Abstract Non-melanoma skin cancer (NMSC) has risen dramatically as a result of chronic exposure to sunlight ultraviolet (UV) radiation, climatic changes and clinical conditions associated with immunosuppression. In spite of considerable progress, our understanding of the mechanisms that control NMSC development and …

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Antibody- and T Cell-Dependent Responses Elicited by a SARS-CoV-2 Adenoviral-Based Vaccine in a Socially Vulnerable Cohort of Elderly Individuals

M. Martínez Moya, Marcela Marrama, Carina Dorazio, Florencia Veigas et autres

BACKGROUND: In spite of compelling evidence demonstrating safety and immunogenicity of adenoviral-based SARS-CoV-2 vaccines in the general population, its effects in socially vulnerable elderly individuals are poorly understood. Here we aimed to investigate the efficacy of two doses of combined vector vaccine, …

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Antibody- and T cell-dependent responses elicited by a SARS-CoV-2 adenoviral-based vaccine in a socially vulnerable cohort of elderly individuals

M. Martínez Moya, Ariel Aleksandroff, Marcela Marrama, Florencia Veigas et autres

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Immune Checkpoints Pathways in Head and Neck Squamous Cell Carcinoma

Florencia Veigas, Yamil Damian Mahmoud, Joaquin Pedro Merlo, Adriana Rinflerch et autres

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors usually diagnosed at an advanced stage and characterized by a poor prognosis. The main risk factors associated with its development include tobacco and alcohol consumption and Human Papillomavirus (HPV) …

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