Yongqiang Feng

Author Correction: Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity

Wei Min Hu, Zhong-Min Wang, Yongqiang Feng, Michail Schizas et autres

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The ascorbate-Tet axis is a checkpoint regulator of naive T-cell quiescence 2257733

Xiaolei Hao, Lu Bai, Jun Li, Beisi Xu et autres

Abstract Introduction T-cell peripheral tolerance is crucial for maintaining immune homeostasis and preventing autoimmunity, which is characterized by limited response of conventional T cells to antigen stimulation. The mechanisms controlling this process remain to be fully elucidated. Methods To investigate the role …

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Rag1-based time-stamp tracing of T-cell developmental origins

Menglin Jiang, Yichao Li, Xinying Zong, Xiaolei Hao et autres

The postnatal T‑cell pool comprises cells at diverse developmental stages, complicating efforts to resolve T‑cell differentiation, maturation, and long‑term adaptation. To address this challenge, we developed Rag1‑mediated time-stamp tracing, a genetic strategy that enables time‑resolved tracking of T‑cell developmental origins. We validate …

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Control of naive T cell reactivity and peripheral tolerance by ascorbate and TET activity

Xiaolei Hao, Lu Bai, Jun Li, Beisi Xu et autres

Peripheral tolerance depends on limiting conventional T cell responses to self-antigens. To define the contribution of nutritional factors and related epigenetic regulation, we perform in vivo CRISPR screening and identify the ascorbate transporter Slc23a2 as a key regulator of naive T cell …

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Aberrant thymic architecture and enhanced interferon signaling in down syndrome

Trent D. Hall, Andrew B. Schild, Lie Li, Heather Sheppard et autres

Abstract Disrupting the mechanisms of thymocyte development and central tolerance can severely affect the immune system and lead to autoimmune disease. It is well established that individuals with Down syndrome (DS) have an elevated risk of autoimmune disease, particularly celiac disease, type …

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Glut3 promotes cellular O-GlcNAcylation as a distinctive tumor-supportive feature in Treg cells

Amit Sharma, Garima Sharma, Zhen Gao, Ke Li et autres

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Dynamic Foxp3–chromatin interaction controls tunable Treg cell function

Ming-Hong He, Xinying Zong, Beisi Xu, Wenjie Qi et autres

Nuclear factor Foxp3 determines regulatory T (Treg) cell fate and function via mechanisms that remain unclear. Here, we investigate the nature of Foxp3-mediated gene regulation in suppressing autoimmunity and antitumor immune response. Contrasting with previous models, we find that Foxp3-chromatin binding is …

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Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement

Xin Lan, Mi Tian, Shanta Alli, Cliff S. Guy et autres

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Characterization of the MT‐2 Treg‐like cell line in the presence and absence of forkhead box P3 (FOXP3)

M. Mccullough, Miriya K. Tune, Johnny Castillo Cabrera, Jose L. Torres-Castillo et autres

regulatory T cells (Tregs) are essential in maintaining immune tolerance and suppressing excessive immune responses. Tregs also contribute to tissue repair processes distinct from their roles in immune suppression. For these reasons, Tregs are candidates for targeted therapies for inflammatory and autoimmune …

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A Framework for False Image Detection with Sample-Oriented Intelligent Adversarial

Li Jun, Jiajie Zhang, Yongqiang Feng

Abstract To develop algorithms capable of automatically detecting and evaluating the authenticity of images and videos, researchers have focused on false image detection algorithms. These algorithms aim to identify the authenticity of images by distinguishing between real images and forged ones generated …

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DNA Methylation in Regulatory T Cell Differentiation and Function: Challenges and Opportunities

Lu Bai, Xiaolei Hao, Julia Lee Keith, Yongqiang Feng

As a bona fide epigenetic marker, DNA methylation has been linked to the differentiation and function of regulatory T (Treg) cells, a subset of CD4 T cells that play an essential role in maintaining immune homeostasis and suppressing autoimmunity and antitumor immune …

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Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation

Jun Li, Beisi Xu, Ming-Hong He, Xinying Zong et autres

Regulatory T (T reg ) cells play crucial roles in suppressing deleterious immune response. Here, we investigate how T reg cells are mechanistically induced in vitro (iT reg ) and stabilized via transcriptional regulation of T reg lineage-specifying factor Foxp3. We find …

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