Annarita Palomba

Sequencing Immunotherapy and Hypofractionated Radiotherapy in Frail Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma

Beatrice Bettazzi, Viola Salvestrini, Marco Banini, Olga Ruggieri et autres

(1) Background: Hypofractionated radiotherapy and immunotherapy (IT) are possible treatment options for HNSCC patients unsuitable for standard curative treatment, yet no high-level evidence supports their combined use. We aim to report on the clinical outcome of a single-center cohort of HNSCC patients …

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Dupilumab in Chronic Rhinosinusitis With Nasal Polyps Patients: Impact on Tissue Eosinophilic Inflammation and Eosinophil Subphenotypes

Alessandra Vultaggio, Matteo Accinno, Emanuele Vivarelli, Maria Elena Milanese et autres

Summary Dupilumab reduces tissue eosinophils in nasal polyps beyond improving clinical and endoscopic outcomes. Dupilumab treatment is associated with a reduction of tissue inflammatory eosinophils that correlates with higher clinical and endoscopic improvement.

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Supplementary data to [Dupilumab in Chronic Rhinosinusitis with Nasal Polyps patients: impact on tissue eosinophilic inflammation and eosinophils subphenotypes]

Alessandra Vultaggio, Matteo Accinno, Emanuele Vivarelli, Maria Elena Milanese et autres

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Supplementary data to [Dupilumab in Chronic Rhinosinusitis with Nasal Polyps patients: impact on tissue eosinophilic inflammation and eosinophils subphenotypes]

Alessandra Vultaggio, Matteo Accinno, Emanuele Vivarelli, Maria Elena Milanese et autres

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Prognostic Value of Worst Pattern of Invasion (WPOI) in Early Stage Oral Cavity Squamous Cell Carcinoma

Carlotta Becherini, Pierluigi Bonomo, Annarita Palomba, Ilaria Camilla Galli et autres

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Pseudomyogenic Hemangioendothelioma of the Femur Treated by Intercalary Resection and Massive Allograft Reconstruction: A Case Report

Fernando N. Martín Cocilova, Elisabetta Neri, Filippo Nozzoli, Tiziana Tatti et autres

Pseudomyogenic hemangioendothelioma (PHME) is a very rare vascular tumor that usually arises in the extremities, mainly cutaneous or subcutaneous, but also occurs in deeper locations, such as muscles and bone. Less than 200 cases have been reported so far, and primary intraosseous …

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Th17-like cells and immunosuppressive macrophages infiltrate tertiary lymphoid structures with distinct maturation status in soft-tissue sarcoma

Petroni Giulia, F. Scolari, Guido Scoccianti, Annarita Palomba et autres

Abstract Tertiary lymphoid structures (TLSs) have been associated with favorable clinical outcome and improved responses to immune checkpoint inhibitors in soft-tissue sarcomas (STSs). However, due to their rarity and high heterogeneity, information regarding the mechanisms involved in TLS formation and contribution to …

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MRI-based radiomic analysis for grading myxoid liposarcoma: a multisequence retrospective study

Silvia Ruggeri, Giuliana Roselli, Roberto Scanferla, Sebastiano Paolucci et autres

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Prediction Of Pathologic Tumor Response by MRI Restaging in Operable Soft Tissue Sarcoma following Preoperative Chemoradiotherapy

Daniela Greto, M. Loi, Giuliana Roselli, Annarita Palomba et autres

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Defining replicability and evaluating reliability of intra-operative cytological bone margins assessment. A study to strengthen previous findings in advanced oral cancer

Giuditta Mannelli, Chiara Marzi, Lara Valentina Comini, Annarita Palomba et autres

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Mepolizumab Reduces Inflammatory Eosinophils in Nasal Polyp Tissue and Restores Histological Alterations

Andrea Matucci, Matteo Accinno, Giandomenico Maggiore, Barbara Brugnoli et autres

BACKGROUND AND OBJECTIVES: Eosinophilic inflammation and IL-5 are key therapeutic targets in type 2 chronic rhinosinusitis with nasal polyposis (CRSwNP). Based on surface expression of CD62L, 2 eosinophil subpopulations, homeostatic and inflammatory, were recently described. Objectives: First, we aimed to investigate the …

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Minor Salivary Gland Biopsy in the Differential Diagnosis of Sicca Syndrome: A Monocentric Cohort Analysis

Elisa Fiorentini, Pamela Bernardini, D. Zeka, Marco Capassoni et autres

Sicca syndrome is a common condition that draws the attention of rheumatologists, and is frequently related to Sjögren's disease (SjD). This study analyzed 164 patients with sicca syndrome (clinically suspected for SjD) who underwent minor salivary gland biopsy (mSGB). Patients completed the …

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