Lauren P. Schewitz‐Bowers

Abstract 4802: CAR-T cell therapy workflow for discovery and development

David Cobeta Lopez, Benita Quist, Sara Compte-Sancerni, Sophie Vermond et autres

Engineered T cell therapies such as Chimeric Antigen Receptor (CAR) T cells and T cell receptor (TCR)-engineered T cells have emerged as a promising therapy. To date, seven CAR-T cell products have been approved by the FDA for the treatment of hematological …

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Abstract 5839: Mimicking the immunosuppressive tumor microenvironment: a complex primary immune cell tumor killing assay to support candidate vaccine or immunomodulator screening

Stephan Brand, Elizabeth Lieverse, Henry John Leonard, Elsenoor J. Klaver et autres

Recent advances in oncology vaccine strategies, from off-the-shelf to personalized approaches offer a promising new weapon in the cancer treatment arsenal. The ability of these vaccines to exploit host immunity by priming and expanding Tumor Associated Antigen (TAA)-specific T cells presents a …

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Abstract 3975: A therapeutic screening platform for assessing antigen-specific T cell-mediated tumor killing in vitro

Elsenoor J. Klaver, Henry John Leonard, Elizabeth Lieverse, Stephan Brand et autres

Abstract Many cancers remain resistant to conventional therapies, consequently there has been an exponential rise in the number of therapeutics harnessing the power of the immune system in an oncology setting, with several remarkable examples of success. High frequencies of infiltrating tumor-specific …

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Abstract 1335: Generating functional CAR-NK cells for cancer immunotherapy

Karina Di Gregoli, Henry John Leonard, Dan Rocca, Sabrina de Munnik et autres

Abstract Chimeric Antigen Receptor-Natural Killer (CAR-NK) cells are rapidly emerging as a promising cellular therapeutic overcoming the potential life-threatening adverse events that may result from CAR-T therapy, including cytokine release syndrome (CRS), neurotoxicity and graft-versus-host disease (GVHD). Due to their intrinsic characteristics, …

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Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia

Madeleine L. Stimpson, Julia Wolf, Bruno Charbit, Emily L. Williams et autres

Regulatory B (Breg) cells are potentially implicated in the pathogenesis of immune thrombocytopenia (ITP). We analysed a prospective cohort of newly diagnosed steroid naïve ITP patients enrolled in the multicentre FLIGHT trial and found that the numbers of Bregs in their peripheral …

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Abstract 2907: Development of a CAR-NK cellular platform for cancer immunotherapy

Karina Di Gregoli, Ravindra Mode, Kaitlin F. Mitchell, David Cobeta-Lopez et autres

Abstract Although Chimeric Antigen Receptor (CAR)-T cell therapy has proven to be successful in treating multiple hematological malignancies, their use is limited due to the potential life-threatening adverse events, including cytokine release syndrome (CRS), neurotoxicity and graft-versus-host disease (GVHD). CAR natural killer …

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Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2

Xiao Hu, Yanli Zou, David A. Copland, Lauren P. Schewitz‐Bowers et autres

BACKGROUND: Targeting helper T cells, especially Th17 cells, has become a plausible therapy for many autoimmune diseases. METHODS: Using an in vitro culture system, we screened an epigenetics compound library for inhibitors of IFN-γ and IL-17 expression in murine Th1 and Th17 …

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CD4+ T cells from patients with glucocorticoid‐refractory immune thrombocytopenia have altered cytokine expression

Madeleine L. Stimpson, Julia Wolf, Emily L. Williams, Philippa J. P. Lait et autres

The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.

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Glucocorticoid treatment in patients with newly diagnosed immune thrombocytopenia switches CD14++CD16+ intermediate monocytes from a pro‐inflammatory to an anti‐inflammatory phenotype

Emily L. Williams, Madeleine L. Stimpson, Philippa J. P. Lait, Lauren P. Schewitz‐Bowers et autres

Summary Immune thrombocytopenia (ITP) is thought to result from an aberrant adaptive autoimmune response, involving autoantibodies, B and T lymphocytes, directed at platelets and megakaryocytes. Previous reports have demonstrated skewed CD4+ T‐helper subset distribution and enhanced production of pro‐inflammatory cytokines such as …

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IL‐10 and IL‐17 expression by CD4+ T cells is altered in corticosteroid refractory immune thrombocytopenia (ITP)

Madeleine L. Stimpson, Philippa J. P. Lait, Lauren P. Schewitz‐Bowers, Emily L. Williams et autres

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Expression by CD4+ T Cells is Altered in Corticosteroid Refractory Immune Thrombocytopenia (ITP)

Madeleine L. Stimpson, Philippa J. P. Lait, Lauren P. Schewitz‐Bowers, Emily L. Williams et autres

Intermediate Monocytes in Acute Alcoholic Hepatitis Are Functionally Activated and Induce IL-17 Expression in CD4+ T Cells

Ashwin Dhanda, Emily L. Williams, Euan Yates, Philippa J. P. Lait et autres

Abstract In humans, the three main circulating monocyte subsets are defined by their relative cell surface expression of CD14 and CD16. They are all challenging to study because their characteristics are strongly context specific, and this has led to a range of …

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