Alfred Paul Senn

Impact of Cooling Curve Type on Sperm DNA Integrity During Cryopreservation

Letica Avi, João Paolo Bilibio, Ana Carolina Martinhago, Martina Cordini et autres

OBJECTIVE: To assess whether sperm DNA fragmentation is affected differently by cryopreservation techniques using different cooling curves before immersion in liquid nitrogen (LN₂). METHODS: A paired case-control study was conducted with 21 semen samples from men undergoing fertility evaluation. Each sample (Fresh …

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Prenatal occupational exposure to endocrine-disrupting chemicals during pregnancy and adult male reproductive hormones

Pauline Blanc‐Petitjean, Rita Rahban, Brigitte Dananché, Alfred Paul Senn et autres

RESEARCH QUESTION: Does maternal occupational exposure to endocrine-disrupting chemicals (EDC) during pregnancy affect reproductive hormone concentrations in adult sons? DESIGN: Data from a cross-sectional study of 2326 Swiss conscripts collected between 2005 and 2017 were analysed. On inclusion, the conscripts' mothers completed …

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Exploring geographical differences in semen quality of young men using spatial dependence analysis

Rita Rahban, Hugo-Alejandro Santa-Ramírez, Alfred Paul Senn, Eric Stettler et autres

STUDY QUESTION: Are semen quality parameters randomly distributed across space, or do they exhibit spatial patterns that may reflect underlying environmental influences? SUMMARY ANSWER: Semen quality parameters are not randomly distributed in Switzerland but exhibit distinct spatial clustering, with identifiable hotspots indicating …

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P-390 Can sperm DNA be affected by different cooling curves in the cryopreservation process?

João Paolo Bilibio, L Avi, Ana Carolina Nogueira Martinhago, Martina Cordini et autres

Abstract Study question Is sperm DNA fragmentation affected differently when using cryopreservation techniques with different cooling curves? Summary answer The seminal cryopreservation method that uses only the stage of exposure to Liquid Nitrogen vapor in the freezing process causes less damage to …

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Effect of ceftiofur sodium and stimbiotic interventions in the periparturient period on sow mortality

Alfred Paul Senn, Aleena Joy, Brooke L Kitting, Edward Jabłoński et autres

Evaluation of the Effects of Different Dietary Sugars on Sperm Parameters in Mice

Vera Lúcia Lângaro Amaral, Paola Stefany Corre Vaz Correia, Alfred Paul Senn, Rafael Alonso Salvador et autres

Protocolos de criopreservação seminal: uma revisão integrativa

Jéssica Dias Vicente, Alfred Paul Senn, Vera Lúcia Lângaro Amaral

A criopreservação é uma técnica utilizada para o armazenamento de células espermáticas por tempo indeterminado, com resultados variáveis na literatura quanto à qualidade espermática após o procedimento. Este estudo é uma revisão integrativa que avaliou a eficiência de diferentes protocolos de criopreservação …

In vitro culture of mechanically isolated murine primary follicles in the presence of human platelet lysate PLTMax

Vera Lúcia Lângaro Amaral, Jhuly Laurentino Nunes, Rafael Alonso Salvador, Alfred Paul Senn et autres

OBJECTIVE: To develop a system for the culture of murine preantral ovarian follicles using Human Serum Albumin (HSA) and Human Platelet Lysate (PLTMax). METHODS: Mechanically isolated preantral follicles (N=146) were obtained from Swiss mice and cultured in DMEM:F12 medium for ten days …

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Development and validation of a sperm-freezing device created using 3D printer technology

Vera Lúcia Lângaro Amaral, Gabriela Reif, Rafael Alonso Salvador, Alfred Paul Senn et autres

OBJECTIVE: To develop and evaluate the effectiveness of a 3D-printed prototype to hold semen straws during the freezing process under safe and reproducible conditions. METHODS: A prototype capable of holding ten straws in liquid nitrogen vapor (LN2) was 3D printed. A second …

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Association between self-reported mobile phone use and the semen quality of young men

Rita Rahban, Alfred Paul Senn, Serge Nef, Martin Röösli

OBJECTIVES: To investigate the association between mobile phone exposure and semen parameters. DESIGN: A nationwide cross-sectional study. SETTING: Andrology laboratories in close proximity to 6 army recruitment centers. PATIENTS: In total, 2886 men from the general Swiss population, 18-22 years old, were …

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Gonadotropin axis and semen quality in young Swiss men after cannabis consumption: Effect of chronicity and modulation by cannabidiol

Fanny Zufferey, Elina Buitrago, Rita Rahban, Alfred Paul Senn et autres

BACKGROUND: While cannabis is the most widely used recreational drug in the world, the effects of phytocannabinoids on semen parameters and reproductive hormones remain controversial. Cannabinoid receptors are activated by these compounds at each level of the hypothalamus-pituitary-gonadotropic axis. OBJECTIVES: To assess …

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Maternal occupational exposure to endocrine-disrupting chemicals during pregnancy and semen parameters in adulthood: results of a nationwide cross-sectional study among Swiss conscripts

Marion Istvan, Rita Rahban, Brigitte Dananché, Alfred Paul Senn et autres

This cross-sectional study shows that men who had been exposed in utero to endocrine disruptors (EDC) are twice more likely to have a low sperm count, below the reference values per ejaculation set by the World Health Organisation.