Prenatal occupational exposure to endocrine-disrupting chemicals during pregnancy and adult male reproductive hormones
Rattachement africain : fr, ch. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
RESEARCH QUESTION: Does maternal occupational exposure to endocrine-disrupting chemicals (EDC) during pregnancy affect reproductive hormone concentrations in adult sons? DESIGN: Data from a cross-sectional study of 2326 Swiss conscripts collected between 2005 and 2017 were analysed. On inclusion, the conscripts' mothers completed a detailed questionnaire about their pregnancy. A job-exposure matrix was used to assess exposure to 10 categories of potential EDC. Reproductive hormones - FSH, LH, total and free testosterone, oestradiol and sex hormone-binding globulin (SHBG) - were determined in serum samples from all conscripts whose mothers were exposed to EDC during pregnancy (n = 138) and a random sample of non-exposed conscripts (n = 276). Multiple linear regression analyses were adjusted for potential confounders. RESULTS: Prenatal exposure to phthalates or alkyl phenolic compounds was significantly associated with higher FSH concentrations (aβ = 0.26, 95% CI 0.03-0.49, and aβ = 0.22, 95% CI 0.02-0.42, respectively) and prenatal exposure to pesticides was significantly associated with higher SHBG concentrations (aβ = 0.22, 95% CI 0.05-0.38). No statistically significant associations were found between other EDC categories and reproductive hormones. CONCLUSIONS: Maternal occupational exposure to certain types of EDC during pregnancy was associated with the concentrations of reproductive hormones in adult sons. These findings require replication in larger, prospective population studies.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prenatal occupational exposure to endocrine-disrupting chemicals during pregnancy and adult male reproductive hormones
- Date Crossref
- 01/03/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Inserm pays non établi dans la noticeOrganisme public
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Institut de Recherche en Santé pays non établi dans la noticeStructure de recherche
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University of Geneva Department of Genetic Medicine and Development pays non établi dans la noticeUniversité ou école supérieure
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Hôpital du Valais pays non établi dans la noticeÉtablissement de santé
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Université de Rennes CHU Rennes pays non établi dans la noticeUniversité ou école supérieure
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Service of Clinical Chemistry and Toxicology pays non établi dans la noticeÉtablissement de santé
Inserm, Institut de Recherche en Santé et Department of Genetic Medicine and Development — University of Geneva, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.