Yanwen Xu

Human testis-specific TTRP regulates circadian clock as an evolutionarily young natural antisense transcript of PER2

Tongyue Chen, Lirong Guo, Han Zhang, Bing Cai et autres

The circadian clock orchestrates a variety of physiological and behavioral processes, endowing the ability to adapt to the cycling environment. Here, we report the identification of TTRP, a TDP-43 pseudogene that emerged in higher Hominoidea species ~8.6 Mya. TTRP is a human …

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Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of advanced maternal age: a randomized, clinical trial

Jin Huang, Rong Li, Lin Zeng, Liang Hu et autres

Abstract Non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) can detect embryo chromosomal aneuploidy by analyzing the cell-free DNA in embryo culture media. However, evidence for its clinical efficacy is insufficient. In this investigator-initiated, multicenter, double-blind, randomised controlled trial, women aged 35-42 who …

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Free apical surface hetero-cellular CDH1 homophilic binding is a major mediator of blastocyst–endometrium interaction in humans

Hanzhang Ruan, Andy Chun Hang Chen, Yuxuan Xue, Kai Chuen Lee et autres

STUDY QUESTION: Is E-cadherin (CDH1) expressed on the free apical surface of endometrial epithelial cells (EECs) involved in embryo attachment? SUMMARY ANSWER: Embryonic signals induced apical expression of endometrial CDH1, which facilitated attachment via hetero-cellular CDH1 homophilic binding. WHAT IS KNOWN ALREADY: …

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Programmed Downregulation of METTL3 is Essential for Decidualization in Both Humans and Mice

Yuqi Hong, Run-Fu Jiang, Shi Tang, Xiaoqi Yang et autres

ABSTRACT N 6 ‐methyladenosine (m 6 A), the most abundant mRNA modification in eukaryotes, plays an essential role in regulating gene expression. Our prior research, alongside that of others, demonstrated that conditional uterine knockout of methyltransferase‐like 3 (METTL3), the enzyme responsible for …

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The METTL3 – PGR – WNT4 axis is critical for human endometrial stromal cell decidualization

Yuqi Hong, Shi Tang, Xiaoqi Yang, Qingyan Zhang et autres

Mouse studies have established the crucial role for uterine m 6 A modification in embryo implantation and decidualization. Nevertheless, the importance of this epigenetic modification in the analogous biological process in humans remains incompletely understood. Here, we show that methyltransferase‐like 3 [METTL3; …

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Associations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome

Ziyi Zheng, Yuanlin Ma, Yue Shi, Yanwen Xu

Abstract Background Polycystic ovary syndrome (PCOS) is among the most common endocrine and metabolic disorders. Kisspeptin, a neuropeptide, which has been implicated in enhancing hypothalamic–pituitary–ovarian (HPO) axis activity, might play a role in the pathogenesis of PCOS. However, previous studies have had …

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Paxlovid for the treatment of severe or critical COVID-19 in children

Linjuan Xiang, Qun Wang, Yanwen Xu, Tong Yu et autres

Abstract Background Paxlovid, known for its efficacy against SARS-CoV-2, is currently limited in its use for treating pediatric COVID-19, particularly in severe or critical cases. Methods We conducted a study within a single-center, prospective cohort of 450 children diagnosed with COVID-19 between …

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Programmed downregulation of METTL3 is essential for decidualization in both humans and mice

Yuqi Hong, Run-Fu Jiang, Shi Tang, Xiaoqi Yang et autres

Abstract N 6 -methyladenosine (m 6 A), the most abundant mRNA modification in eukaryotes, plays an essential role in regulating gene expression. Our prior research, alongside that of others, demonstrated that conditional uterine knockout of methyltransferase-like 3 (METTL3), the enzyme responsible for …

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The effect of antibiotic treatment on pregnancy outcomes in patients with mild chronic endometritis undergoing in vitro fertilization

Yiyao Xu, Wenjun Chen, Qingyan Zhang, Canquan Zhou et autres

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Recommendations for the management of GnRH‐ant for ovarian stimulation in the assistant reproductive process: Benefits and harms for different ovarian response population

Rong Li, Rui Yang, Junhao Yan, Yang Song et autres

Abstract Introduction: Gonadotropin‐releasing hormone antagonists (GnRH‐ant) are commonly used during controlled ovarian stimulation (COS) in the in vitro fertilization (IVF) process to prevent premature luteinization and to ensure follicles mature synchronously. The 2020 guideline from European Society of Human Reproduction and Embryology …

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Assisted Reproductive Technology in China: A Commentary

Fang Gu, Yao Lu, Yanwen Xu, Yun Sun

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Author response for "The METTL3 – PGR – WNT4 axis is critical for human endometrial stromal cell decidualization"

Yuqi Hong, Shi Tang, Xiaoqi Yang, Qingyan Zhang et autres