Pariya Sukhumalchandra

T cell receptor mimic CAR T cells targeting cathepsin G signal peptide

Jun Yan, Chunhua Shi, Guojun Yang, Ze Tian et autres

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Immunotherapy targeting a leader sequence cathepsin G-derived peptide

Chunhua Shi, Ze Tian, Jun Yan, Mao Zhang et autres

Myeloid azurophil granules provide a rich source of intracellular leukemia antigens. Cathepsin G (CG) is a serine protease that has higher expression in acute myeloid leukemia (AML) blasts in comparison to normal myeloid progenitors. Based on the unique biology of HLA-A*0201 (HLA-A2), …

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A Phase I Study of Nivolumab in Combination with Ipilimumab for the Treatment of Patients with High Risk or Refractory/Relapsed Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation

Gheath Alatrash, Cristina Knape, Laura Kay Whited, Dawen Sui et autres

Background: The prognosis for patients with AML and MDS who relapse after allogeneic stem cell transplant (allo-SCT) is dismal. AML is susceptible to immunotherapy, as evidenced by the success of allo-SCT. Enhancing graft-versus-leukemia effect of allo-SCT is a major area of focus. …

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Immunotherapy Targeting a Leader Sequence Cathepsin G-Derived Peptide

Gheath Alatrash, Chunhua Shi, Ze Tian, Jun Yan et autres

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Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target

Lisa M. Becker, Gregory A. Lizee, Steven Mitchell Kornblau, Haven R. Garber et autres

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AML Immunotherapy Using a Novel Tcrm-Based Bispecific Antibody That Targets a Leader Sequence Peptide Derived from Cathepsin G

Chunhua Shi, Ze Tian, Jun Yan, Mao Zhang et autres

Introduction: Myeloid azurophil granules provide a rich source of intracellular leukemia antigens. Cathepsin G (CG) is a serine protease that has higher expression in AML blasts in comparison to normal myeloid progenitors. Based on the unique biology of HLA-A*0201 (HLA-A2), in which …

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Abstract 2995: Cross-presented serine proteases as immunotherapy targets for lung cancer and osteosarcoma

Amber Gibson, Pariya Sukhumalchandra, Céline Kerros, Na Qiao et autres

Abstract Background: Immunotherapy is the standard of care for many solid tumor malignancies. However, due to a paucity of known tumor antigens in non-small cell lung cancer (NSCLC) and osteosarcoma (OS), identification of novel immunogenic antigens is needed. Our group has experience …

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Data from A Novel HLA-A*0201 Restricted Peptide Derived from Cathepsin G Is an Effective Immunotherapeutic Target in Acute Myeloid Leukemia

Mao Zhang, Pariya Sukhumalchandra, Atim A. Enyenihi, Lisa S. St. John et autres

Abstract Purpose: Immunotherapy targeting aberrantly expressed leukemia-associated antigens has shown promise in the management of acute myeloid leukemia (AML). However, because of the heterogeneity and clonal evolution that is a feature of myeloid leukemia, targeting single peptide epitopes has had limited success, …

Supplementary Figures 1 - 4, Tables 1 - 2 from A Novel HLA-A*0201 Restricted Peptide Derived from Cathepsin G Is an Effective Immunotherapeutic Target in Acute Myeloid Leukemia

Mao Zhang, Pariya Sukhumalchandra, Atim A. Enyenihi, Lisa S. St. John et autres

PDF file - 706k, Figure S1. CG is ubiquitinated in AML. Figure S2. CG1 is a naturally processed epitope that is eluted from leukemia cell surface. Figure S3. CG expression by each of the AML samples used in the cytotoxicity assays. Figure …

Supplementary Figures 1 - 4, Tables 1 - 2 from A Novel HLA-A*0201 Restricted Peptide Derived from Cathepsin G Is an Effective Immunotherapeutic Target in Acute Myeloid Leukemia

Mao Zhang, Pariya Sukhumalchandra, Atim A. Enyenihi, Lisa S. St. John et autres

PDF file - 706k, Figure S1. CG is ubiquitinated in AML. Figure S2. CG1 is a naturally processed epitope that is eluted from leukemia cell surface. Figure S3. CG expression by each of the AML samples used in the cytotoxicity assays. Figure …

Data from A Novel HLA-A*0201 Restricted Peptide Derived from Cathepsin G Is an Effective Immunotherapeutic Target in Acute Myeloid Leukemia

Mao Zhang, Pariya Sukhumalchandra, Atim A. Enyenihi, Lisa S. St. John et autres

Abstract Purpose: Immunotherapy targeting aberrantly expressed leukemia-associated antigens has shown promise in the management of acute myeloid leukemia (AML). However, because of the heterogeneity and clonal evolution that is a feature of myeloid leukemia, targeting single peptide epitopes has had limited success, …

Data from Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells

Victor Gall, Anne V. Philips, Na Qiao, Karen Clise-Dwyer et autres

Abstract Early-phase clinical trials evaluating CD8+ T cell–eliciting, HER2-derived peptide vaccines administered to HER2+ breast cancer patients in the adjuvant setting suggest synergy between the vaccines and trastuzumab, the mAb targeting the HER2 protein. Among 60 patients enrolled in clinical trials evaluating …